| Topics | Lecture Contents | Lecturers | |||||||||||||||||||||||||||||||||||||
| 1 | Karyotype
characteristics, main features of the chromosome, heterochromatin and
euchromatin, chromosome banding Note I Note II Note III | Dr. Choong | |||||||||||||||||||||||||||||||||||||
| 2 | Chromosome organisation - fine structure, packaging of chromosome fibre Note I | Dr. Choong | |||||||||||||||||||||||||||||||||||||
| 3 | Mitosis and meiosis - changes to chromosome structure in relation to its role during cell division, synapsis of homologous chromosomes, crossing-over and chiasma formation Note I Note II Note III | Dr. Choong | |||||||||||||||||||||||||||||||||||||
| 4 | Specialized chromosomes - polytene chromosomes, lampbrush chromosomes, ring chromosomes, isochromosomes, B chromosomes | Prof. Mahani | |||||||||||||||||||||||||||||||||||||
| 5 | Function of autosomes and sex chromosomes - linkage, sex determination, dosage compensation | Prof. Mahani | |||||||||||||||||||||||||||||||||||||
| 6 | Variation in chromosome structure - how they occur, examples and effects of deletions, duplications, inversions and translocations | Prof. Mahani | |||||||||||||||||||||||||||||||||||||
| 7 | Variation in chromosome number - aneuploidy, polyploidy, haploidy | Prof. Mahani | |||||||||||||||||||||||||||||||||||||
| 8 | Population cytogenetics - genetic polymorphisms and adaption | Prof. Mahani | |||||||||||||||||||||||||||||||||||||
| Practicals a) Human chromosomes b) Mitosis c) Meiosis d) Polytene chromosomes e) Sex chromatin |
| Assessment: | |||
| Mid Semester Evaluation | topics 1-3 | 25% | |
| Final Semester Examination | all topics | 50% | |
| Practical reports | - | 25% | |
| Assignment | - | 5% | |
| Total | - | 105% |