Sains Malaysiana 34(2): 107-112 (2005)

 

Sintesis dan Pencirian Sebatian Kompleks

Diorganostanum(lV) ditiokarbamat

(Synthesis and Characterization of Diorganotin(IV)

dithiocarbamate Complexes)

 

 

Mukhlis Sanuddin, Yang Farina, Bohari M. Yamin & Ibrahim Baba

Pusat Pengajian Sains Kimia dan Teknologi Makanan

 Fakulti Sains dan Teknologi

Universiti Kebangsaan Malaysia

 43650 UKM Bangi, Selangor D.E. Malaysia

 

 

 

ABSTRAK

 

Sebatian kompleks diorganostanum( N) N-benzilmetilditiokarbamat dan diorganostanum( N) N-etil-n-propilditiokarbamat telah disintesis dengan tindak balas campuran organostanum( N) klorida dengan terbitan amina bersama karbon disulfida. Semua sebatian kompleks ini telah dicirikan menggunakan analisis unsur; spektroskopi inframerah dan resonans magnet nukleus 1H dan l3C, sementara struktur hablur yang terbentuk dikaji secara kristalografi sinar-X hablur tunggal. Kompleks dimetilstanum(N) N-benzilmetilditiokarbamat menunjukkan sistem hablur monoklinik dengan kumpulan ruang P2/n. Kompleks organostanum(N) ditiokarbamat aromatik manunjukkan aktiviti sitotoksik terhadap sel kanser HL60 dan MCF-7, sedangkan kompleks organostanum(N) ditiokarbamat alifatik tidak memberikan aktiviti terhadap sel kanser HL60 dan MCF-7.

 

Kata kunci: Ditiokarbamat, benzil

 

 

ABSTRACT

 

The complexes of diorganotin( N) N-benzylmethyldithiocarbamates and diorganotin( N) N-ethyl-n-propyldithiocarbamates have been successfully synthesized from organotin(IV) chloride with the respective amines and carbon disulfide. All the complexes were characterized using elemental analyses, infrared, IH and l3C nuclear magnetic resonance (NMR) spectroscopic methods, while the structure was determined by X-ray diffraction methods. The complexes of dimethyltin(N) N-benzylmethyldithiocarbamate crystallised in the monoclinic system with space group P2/n. The aromatic organostannum(N) dithiocarbamates are more cytotoxic towards HL60 and MCF-7 cancer cells than the aliphatic complexes which, did not show cytotoxicity behaviour towards HL60 and MCF-7 cells.

 

Keywords: Dithiocarbamate, benzyl

 

 

RUJUKAN/REFERENCES

 

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