Sains Malaysiana 37(4): 395-399  (2008)

 

Fabrication of Porous Hydroxyapatite for Bone Graft

Substitutes via Gas Technique

(Fabrikasi Hidroksiapatit Poros Melalui Teknik Gas

sebagai Tulang Geraf Gantian)

 

 

Mohd Reusmaazran Yusof & Idris Besar

Malaysian Nuclear Agency

Bangi, 43000 Kajang, Selangor D. E. Malaysia

 

Roslinda Shamsudin & Syafiq Baharuddin

School of Applied Physics, Faculty of Science and Technology

Universiti Kebangsaan Malaysia

43600 UKM Bangi, Selangor D. E. Malaysia

 

 

Received :  2 October 2007 / Accepted :   22 February 2008

 

 

ABSTRACT

 

Porous hydroxyapatite (HAp) as a bone graft substitute was produced via gas technique with three different concentrations of hydrogen peroxide (H2O2) namely 20, 30 and 50%. Hydroxyapatite(HA) slurries with different concentration were produced by mixing between H2O2 solutions and HA powder (L/P) with different ratio i.e. 0.9 to 2.20 ml.g-1. Different L/P ratio and H2O2 concentration affected the porosity, interconnectivity and compressive strength of HAp sample. Changes in L/P ratio between 0.9 to 2.20 ml.g-1, increases the porosity around 50 - 65% at 20% H2O2 concentration. Porosity increases with the L/P values and H2O2 concentration which 76% of porosity was obtained at 50% H2O2 and 2.20 mlg-1 of L/P. The compressive strength of HAp is in the range of 0.5 to 2.15 MPa and is found decreasing with the increasing of L/P values.

 

Keywords:  Compressive strength; interconnectivity; porous hydroxyapatite; porosity

 

 

ABSTRAK

 

Hidroksiapatit poros (HAp) sebagai tulang geraf gantian sintetik dihasilkan melalui teknik gas dengan menggunakan gas hidrogen peroksida (H2O2) pada kepekatan 20, 30 dan 50%. Buburan hidroksiapatit(HA) dihasilkan daripada nisbah larutan H2O2 terhadap serbuk HA (L/P) antara 0.9 hingga 2.20 mlg-1 bagi memperolehi kelikatan buburan yang berlainan. Kepekatan larutan H2O2 dan nisbah L/P yang berbeza mempengaruhi keporosan, keterjalinan hubung antara liang dan kekuatan mampatan sampel HAp. Perubahan L/P antara 0.9 hingga 2.20 mlg-1 telah meningkatkan keporosan sebanyak 50 - 65% pada 20% kepekatan larutan H2O2. Keporosan meningkat dengan nilai L/P  dan kepekatan larutan H2O2 dimana 76% keporosan dicapai pada kepekatan 50% larutan H2O2 dan L/P sekitar 2.20 mlg-1. Kekuatan mampatan HAp adalah antara 0.5 hingga 2.15 MPa dan didapati menurun dengan peningkatan nisbah L/P.

 

Kata kunci: Hidroksiapatit poros; kekuatan mampatan; keporosan; kerterjalinan hubung 

 

 

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