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Bacterial Cellulose Film Coating as Drug
Delivery System: Physicochemical,
Thermal and Drug Release Properties
(Penyalutan Filem Selulosa Bakteria sebagai Satu Sistem Penyampaian Dadah:
Sifat-sifat Fizikokima, Terma dan Pelepasan Dadah)
Mohd Cairul Iqbal Mohd Amin*, Abadi Gumah Abadi, Naveed Ahmad
Haliza Katas & Jamia Azdina Jamal
Faculty
of Pharmacy, Universiti Kebangsaan
Malaysia, Jalan Raja Muda Abdul Aziz
50300,
Kuala Lumpur, Malaysia
Received:
21 July 2011 / Accepted: 20 October 2011
ABSTRACT
There has been an increasing interest in
the use of natural materials as drug delivery vehicles due to their
biodegradability, biocompatibility and ready availability. These properties
make bacterial cellulose (BC), from nata de
coco, a promising biopolymer for drug delivery applications. The
aim of this study was to investigate the film-coating and drug release
properties of this biopolymer. Physicochemical, morphological and thermal
properties of BC films were studied.
Model tablets were film coated with BC, using a
spray coating technique, and in
vitro drug release studies of these tablets were investigated. It
was found that BC exhibited excellent
ability to form soft, flexible and foldable films without the addition of any
plasticizer. They were comparable to AquacoatECD (with
plasticizer) in tensile strength, percentage elongation and elasticity modulus.
Differential scanning calorimetry (DSC) BC showed a
high Tg value
indicating thermally stability of films. These results suggest that BC can be
used as novel aqueous film-coating agent with lower cost and better film
forming properties than existing film-coating agents.
Keywords:
Bacterial cellulose; drug delivery; DSC; film-coating; Young’s modulus
ABSTRAK
Penggunaan bahan semula jadi sebagai satu pendekatan penyampaian dadah semakin mendapat perhatian disebabkan sifatnya yang bioterurai, bioserasi dan mudah diperoleh. Kepelbagaian sifat ini menjadikan selulosa bakteria (BC) daripada nata de coco, menjanjikannya sebagai satu biopolimer untuk aplikasi penyampaian dadah. Kajian ini dilakukan bertujuan untuk menyelidiki sifat penyalutan filem dan pelepasan dadah biopolimer tersebut. Kajian fizikokimia, morpologi, dan terma BC telah dilakukan. Penyelidikan ke atas model tablet yang disalutiBC menggunakan kaedah penyalutan secara semburan dan kajian pelepasan dadah secarain vitro dari tablet telah dilakukan. Adalah didapati BC menunjukkan keupayaan yang hebat untuk membentuk filem yang lembut, fleksibel, mudah dilipat tanpa menambah sebarang bahan pemplastik. Ianya setanding dengan Aquacoat ECD (dengan bahan pemplastik) daripada segi kekuatan tensil, peratus pemanjangan dan modulus keelastikan. Pengesanan pembezaan kalorimeter (DSC) BC menunjukkan satu nilai Tg yang tinggi membuktikan kestabilan filem secara terma. Hasil keputusan mencadangkanBC boleh digunakan sebagai agen penyalut filem akues yang baru pada kos yang rendah dan bersifat pembentukan filem lebih baik berbanding agen penyalutan filem yang sedia ada.
Kata kunci: DSC; modulus Young; penyalutan filem; penyampaian dadah; selulosa bakteria
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*Corresponding author; email: mciamin@pharmacy.ukm.my
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