Sains Malaysiana 42(2)(2013): 167–173

Preparation, Characterization and Properties of Core-Shell Cobalt Ferrite/Polycaprolactone Nanomagnetic Biomaterials

(Penyediaan, Pencirian dan Sifat-sifat Rangka-Teras Nanomagnetik Biobahan Kobalt Ferit/Polikaprolakton)

Khoo Kok Siong*, Nur Farhana Amari, Tan Chun Yuan, Shahidan Radiman,

Redzuwan Yahaya & Muhamad Samudi Yasir

School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia

Received: 8 March 2012 / Accepted: 23 June 2012

ABSTRACT

Combination of magnetic and biocompatible materials to form core-shell nanomaterials has been widely used in medical fields. These core-shell magnetic biomaterials have a great potential for magnetic fluid hyperthermia (MFH) treatment to remedy cancer. The aims of this study were to investigate the production of core-shell cobalt ferrite/polycaprolactone (CoFe2O4/PCL) nanomaterials with different ratios of cobalt ferrite to caprolactone, to study the effects of using polymer in reducing the agglomerations between particles and to determine the structure, morphology, thermal and magnetic properties of these core-shell nanomaterials. The core-shell nanomaterials were produced by in situ polymerization method. The formation of the CoFe2O4/PCL was investigated by means of Fourier transform infrared spectroscopy (FTIR), x-ray diffractometer (XRD) and transmission electron microscopy (TEM). Its thermal properties were determined by using thermogravimetric analyzer (TGA). The vibrating sample magnetometer (VSM) was used to reveal the magnetic properties. The results for the XRD and FTIR spectra demonstrated the formation of cobalt ferrite and polycaprolactone in core-shell nanomaterials. From the TEM results, it was seen that the core-shell CoFe2O4/PCL nanomaterials were best formed at a ratio of CoFe2O4 to monomer caprolactone mixtures of 1:4.

Keywords: Cobalt ferrite; core-shell nanomaterials; polycaprolactone; TEM image

ABSTRAK

Gabungan penggunaan bahan bersifat magnetik dan bioserasi bagi menghasilkan rangka-teras nanobahan telah digunakan secara meluas dalam bidang perubatan. Rangka teras biobahan magnet ini mempunyai potensi yang besar sebagai hipertemia cecair magnetik (MFH) bagi merawat barah. Tujuan kajian ini adalah untuk mengkaji penghasilan rangka-teras nanobahan CoFe2O4/PCL dalam kadar nisbah kobalt ferit dan kaprolakton yang berbeza, mengenal pasti kesan penggunaan polimer bagi mengurangkan penggumpalan zarah-zarah kobalt ferit dan melakukan pencirian struktur, morfologi, haba dan magnetik terhadap nanobahan ini. Rangka-teras nanobahan ini dihasilkan melalui proses pempolimeranin situ. Pembentukannya ditentukan menggunakan teknik pembelauan sinar-x (XRD), spektrometri transformasi Fourier inframerah (FTIR) dan mikroskop transmisi elektron (TEM). Sifat haba nanobahan ini dicirikan menggunakan penganalisis termogravimetri (TGA). Magnetometer sampel bergetar (VSM) pula digunakan bagi mengetahui sifat magnet bahan. Hasil daripada XRD dan spektrum FTIR menunjukkan kehadiran kobalt ferit dan polikaprolakton dalam sampel rangka-teras nanobahan. Morfologi daripada imej TEM menunjukkan rangka-teras nanobahan hanya terbentuk pada nisbah campuran 1:4 kobalt ferit ke kaprolakton.

Kata kunci: Imej TEM; kobalt ferit; nanobahan rangka-teras; polikaprolakton

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*Corresponding author; email: khoo@ukm.my