Sains Malaysiana 44(10)(2015): 1473–1479

Effects of Progressive Resistance Exercises on Quality of Life, Body Composition and Muscle Strength in Patients with HIV

(Kesan Latihan Rintangan Progresif terhadap Kualiti Hidup, Komposisi Tubuh dan Kekuatan Otot dalam Kalangan Pesakit HIV)

MOHAMAD SHARIFF A. HAMID¹* & STELLA JANE JOSEPH RAJAH²

¹Unit of Sports Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur

Malaysia

²Department of Sports Medicine, Cheras Rehabilitation Hospital, 56000 Cheras

Selangor

Received: 2 April 2015/Accepted: 4 June 2015

ABSTRACT

This study assessed the effects of progressive resistance exercise programmes on self-reported health related quality of life, body composition and muscle strength among patients with HIV. Twenty-nine men with HIV were randomly assigned to progressive resistance exercise programme using elastic band (PRE group) (n=14) or resistance exercise programme without elastic band (comparative group) (n=15). Both groups underwent exercise programmes for 12 weeks. Self-reported health related quality of life, body compositions and isometric shoulder lift strength were assessed at baseline and at week 12. Ten and nine men in the intervention and comparative groups, respectively, completed the 12-week programme. Participants in the comparative group showed significant improvements in the domain of mental health (p<0.05). No significant changes in all body composition parameters were found in both groups with time. Both groups showed significant improvements in peak and average shoulder lift strength (intervention, p=0.001; p=0.001; control, p=0.008; p=0.016). Progressive resistance exercise programmes significantly improves shoulder lift strength, showed positive effects on self-reported health related quality of life scores among patients with HIV.

Keywords: Health; HIV; physical; psychological; training

ABSTRAK

Kajian in menilai kesan program latihan rintangan progresif terhadap kualiti hidup, komposisi tubuh dan kekuatan otot dalam kalangan penghidap HIV. Dua-puluh sembilan lelaki yang menghidap HIV diperuntukkan secara rawak kepada kumpulan program latihan rintangan progresif menggunakan getah elastik (kumpulan PRE) (n=14) atau program latihan rintangan tanpa getah elastik (kumpulan perbandingan) (n=15). Kedua-dua kumpulan melalui program latihan selama 12 minggu. Laporan kendiri kualiti hidup, komposisi tubuh dan kekuatan angkatan otot bahu dinilai pada pemulaan dan minggu ke-12. Sepuluh dan sembilan peserta daripada kumpulan PRE dan kumpulan perbandingan masing-masing menamatkan program selama 12 minggu. Peserta daripada kumpulan perbandingan menunjukkan peningkatan signifikan dalam domain kesihatan mental (p<0.05). Tiada perubahan signifikan pada kesemua parameter komposisi tubuh dengan masa dalam kedua-dua kumpulan. Kedua-dua kumpulan menunjukkan peningkatan signifikan pada puncak dan purata kekuatan angkatan otot bahu (PRE, p=0.001 & p=0.001; perbandingan, p=0.008 & p=0.016). Program latihan rintangan progresif meningkatkan kekuatan angkatan otot bahu dengan signifikan dan menunjukkan kesan positif terhadap kualiti hidup dalam kalangan pengidap HIV.

Kata kunci: Fizikal; HIV; kesihatan; latihan; psikologi

REFERENCES

American College of Sports Medicine (ACSM). 2010. ACSM’s Resources for Clinical Exercise Physiology: Musculoskeletal, Neuromuscular, Neoplastic, Immunologic and Hematologic Condition. 2nd ed. Riverwood, IL: Lippincott Williams & Wilkins Publication.

Anderson, C.E., Gary, A.S. & John, A.S. 2008. The effects of combining elastic and free weight resistance on strength and power in athletes. Journal of Strength and Conditioning Research 22(2): 567-574.

Arpinelli, F., Visona, G., Bruno, R., DeCarli, G. & Apolone, G. 2000. Health-related quality of life in asymptomatic patients with HIV: Evaluation of the SF-36 health survey in Italian patients. Pharmacoeconomics 18(1): 63-72.

Baigis, J., Denise, M.K., Gary, C., Arlene, B., Denise, J. & Albert, W.W. 2002. Effectiveness of a home-based exercise intervention for HIV-infected adults: A randomized trial. The Journal of the Association of Nurses in AIDS Care (JANAC) 13(2): 33-45.

Barba, C., Cavalli-Sforza, T., Cutter, J., Darnton-Hill, I., Deurenberg, P., Deurenberg-Yap, M., Gill, T., James, P., Ko, G., Kosulwat, V., Kumanyika, S., Kurpad, A., Mascie-Taylor, N., Moon, H.K., Nakadomo, F., Nishida, C., Noor, M.I., Reddy, K.S., Rush, E., Schultz, J.T., Seidell, J., Stevens, J., Swinburn, B., Tan, K., Weisell, R., Zhao-Su, W., Yajnik, C.S., Yoshiike, N. & Zimmet, P. 2004. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363(9403): 157-163.

Bhasin, S., Storer, T.W., Javanbakht, M., Berman, N., Yarasheski, K.E., Phillips, J., Dike, M., Sinha-Hikim, I., Shen, R., Hays, R.D. & Beall, G. 2000. Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. Journal of the American Medical Association 283(6): 763-770.

Bing, E.G., Hays, R.D., Jacobson, L.P., Chen, B., Gange, S.J., Kass, N.E., Chmiel, J.S. & Zucconi, S.L. 2000. Health-related quality of life among people with HIV disease: Results from the multicentre AIDS cohort study. Quality of Life Research 9(1): 55-63.

Call, S.A., Klapow, J.C., Stewart, K.E., Westfall, A.O., Mallinger, A.P., DeMasi, R.A., Centor, R. & Saag, M.S. 2001. Health-related quality of life and virologic outcomes in an HIV clinic. Quality of Life Research 9: 977-985.

Carrieri, P., Spire, B., Duran, S., Katlama, C., Peyramond, D., Francois, C., Chene, G., Lang, J.M., Moatti, J.P., Leport, C. & APROCO Study Group. 2003. Health-related quality of life after 1 year of highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes 32: 38-47.

Clark, R.H., Feleke, D., Din, M., Yasmin, T., Singh, G., Khan, F.A. & Rathmacher, J.A. 2000. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: A randomized, double-blind, placebo-controlled study. Journal of Parenteral & Enteral Nutrition 24(3): 133-139.

Clayson, D.J., Wild, D.J., Quarterman, P., Duprat-Lomon, I., Kubin, M. & Coons, S.J. 2006. A comparative review of health-related quality of life measures for use in HIV/AIDS clinical trials. PharmacoEconomics 24(8): 751-765.

Coats, J.S. 2002. Origin of symptoms in patients with cachexia with special reference to weakness and shortness of breath. International Journal of Cardiology 85(1): 133-139.

Corcoran, C. & Grinspoon, S. 1999. Treatments for wasting in patients with the acquired immunodeficiency syndrome. The New England Journal of Medicine 340(22): 1740-1750.

Dalakas, M.C., Illa, I., Pezeshkpour, G.H., Laukaitis, J.P., Cohen, B. & Griffin, J.L. 1990. Mitochondrial myopathy caused by long-term zidovudine therapy. The New England Journal of Medicine 322(16): 1098-1105.

Fillipas, S., Leonie, B.O., Michael, J.B. & Catherine, L.C. 2006. A six-month, supervised, aerobic and resistance exercise program improves self-efficacy in people with human immunodeficiency virus: A randomised controlled trial. The Australian Journal of Physiotherapy 52(3): 185-190.

Grinspoon, S., Corcoran, C., Parlman, K., Costello, M., Rosenthal, D., Anderson, E., Stanley, T., Schoenfeld, D., Burrows, B., Hayden, D., Basgoz, N. & Klibanski, A. 2000. Effects of testosterone and progressive resistance training in eugonadal men with AIDS wasting. A randomized, controlled trial. Annals of Internal Medicine 133(5): 348-355.

Grinspoon, S., Corcoran, C., Rosenthal, D., Stanley, T., Parlman, K., Costello, M., Treat, M., Davis, S., Burrows, B., Basgoz, N. & Klibanski, A. 1998. Quantitative assessment of cross-sectional muscle area, functional status, and muscle strength in men with the acquired immunodeficiency syndrome wasting syndrome. Journal of Clinical Endocrinology & Metabolism 84(1): 201-206.

Grinspoon, S., Corcoran, C., Askari, H., Schoenfeld, D., Wolf, L., Burrows, B., Walsh, M., Hayden, D., Parlman, K., Anderson, E., Basgoz, N. & Klibanski, A. 1998. Effects of androgen administration in men with the AIDS wasting syndrome - A randomized, double-blind, placebo-controlled trial. Annals of Internal Medicine 129(1): 18-23.

Hirsch, C.H., Holly, R.G., Shaffrath, J.D. & Hawkins, D.A. 1996. Effect of resistance band exercises on physical performance in community dwelling frail elders. Gerontology 36: 53-64.

Hostler, D.D., Schwirian, C.C., Campos, G., Toma, K., Crill, M.T., Hagerman, G.R., Hagerman, F.C. & Staron, R.S. 2001. Skeletal muscle adaptations in elastic resistance-trained young men and women. European Journal of Applied Physiology 86(2): 112-118.

Hsiung, P.C., Fang, C.T., Chang, Y.Y., Chen, M.Y. & Wang, J.D. 2005. Comparison of WHOQOL-BREF and SF-36 in patients with HIV infection. Quality of Life Research 14: 141-150.

Kong, A. & Edmonds, P. 2002. Testosterone therapy in HIV wasting syndrome: Systematic review and meta-analysis. The Lancet Infectious Diseases 2(11): 692-699.

Melchior, J.C., Niyongabo, T., Henzel, D., Durack-Bown, I., Henri, S.C. & Boulier, A. 1998. Malnutrition and wasting, immunodepression, and chronic inflammation as independent predictors of survival in HIV-infected patients. Nutrition 15(11): 865-869.

Page, P. & Ellenbecker, T.S. 2003. The Scientific and Clinical Application of Elastic Resistance. Champaign, IL: Human Kinetics Publication.

Peterson, M.D. 2010. Resistance exercise for sarcopenic outcomes and muscular fitness in aging adults. Strength and Conditioning Journal 32(3): 52-63.

Roubenoff, R.R., McDermott, A., Weiss, L., Suri, J., Wood, M., Bloch, R. & Gorbach, S. 1999. Short-term progressive resistance training increases strength and lean body mass in adults infected with human immunodeficiency virus. Aids 13(2): 231-239.

Ruxrungtham, K., Brown, T. & Phanuphak, P. 2004. HIV/Aids in Asia. The Lancet 362: 69-82.

Schambelan, M., Mulligan, K., Grunfeld, C., Daar, E.S., LaMarca, A., Kotler, D.P., Wang, J., Bozzette, S.A. & Breitmeyer, J.B. 1996a. Recombinant human growth hormone in patients with HIV-associated wasting. A randomized, placebo-controlled trial. Serostim study group. Annals of Internal Medicine 125(11): 873-882.

Shabert, J.K., Winslow, C., Lacey, J.M. & Wilmore, D.W. 1999. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: A randomized, double-blind controlled trial. Nutrition 15(11-12): 860-864.

Souza, P.M.L., Jacob-Filho, W., Santarém, J.S., Da Silva, A.R., Li, H.Y. & Burattini, N.M. 2008. Progressive resistance training in elderly HIV-positive patients: Does it work?. Clinics 63(5): 619-624.

Spence, D.W., Galantino, M.L., Mossberg, K.A. & Zimmerman, S.O. 1990. Progressive resistance exercise: Effect on muscle function and anthropometry of a select AIDS population. Archives of Physical Medicine and Rehabilitation 71(9): 644-648.

Strawford, A., Barbieri, T., Loan, M.V., Parks, E., Catlin, D., Barton, N., Neese, R., Christiansen, M., King, J. & Hellerstein, M.K. 1999. Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV-related weight loss: A randomized controlled trial. Journal of the American Medical Association 281(14): 1282-1290.

Süttmann, U., Ockenga, J., Selberg, O., Hoogestraat, L., Deicher, H. & Müller, M.J. 1995. Incidence and prognostic value of malnutrition and wasting in human immunodeficiency virus- infected outpatients. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 8(3): 239-246.

Volaklis, K.A. & Savvas, P.T. 2005. Resistance exercise training in patients with heart failure. Sports Medicine 35(12): 1085- 1103.

Ware, J.E., Kosinski, M. & Keller, S.K. 1994. SF-36® Physical and Mental Health Summary Scales: A User’s Manual. Boston, MA: The Health Institute. http://www.sf-36.org. Accessed on 1 November 2011.

Waters, D., Danska, J., Hardy, K., Koster, F., Qualls, C., Nickell, D., Nightingale, S., Gesundheit, N., Watson, D. & Schade, D. 1996. Recombinant human growth hormone, insulin-like growth factor 1, and combination therapy in AIDS-associated wasting. A randomized, double-blind, placebo-controlled trial. Annals of Internal Medicine 125(11): 865-872.

Wheeler, D.A., Gibert, C.L., Launer, C.A., Muurahainen, N., Elion, R.A., Abrams, D.I. & Bartsch, G.E. 1998. Weight loss as a predictor of survival and disease progression in HIV infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 18(1): 80-85.

Wolfe, F. 1995. Health status questionnaires. Rheumatic Disease Clinics of North America. 21: 445-464.

*Corresponding author; email: ayip@um.edu.my