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Sains Malaysiana 44(2)(2015): 301–308
Modeling of the Dissolution Kinetics of Arbutus Wild Berries-Based Tablets as Evaluated by Electric Conductivity (Permodelan Pembubaran Kinetik Arbutus Beri Liar Berasaskan Tablet Dinilai oleh
Kekonduksian Elektrik)
TOUNSIA ABBAS-AKSIL
& SALEM BENAMARA*
Laboratory
of Soft Technologies and Biodiversity (LTDVPMB), Faculty of Sciences
University
M'hamed Bougara
of Boumerdès, 35000 Boumerdès,
Algeria
Received: 23 April
2013/Accepted: 5 August 2014
ABSTRACT
Lyophilized powder (LP)
from Algerian arbutus wild berries (Arbutus unedo L.) was obtained. This present paper reports
about the dissolution (releasing) properties of LP-based
tablets, evaluated through the electric conductivity (EC) of distilled water
which is employed as surrounding medium, at three different temperatures (291,
298 and 309 K). In addition to this, secondary physicochemical characteristics
such as elementary analysis, color and compressibility were evaluated.
Regarding the modeling of ionic transfer, among the three tested models, namely
Peleg, Singh et al. and Singh and Kulshestha, the
latter seems to be the most appropriate (R2 =
0.99), particularly in the case of compacted tablets under 2000 Pa. The
temperature dependence of the dissolution process was also studied applying
Arrhenius equation (R2>0.8) which allowed to deduce the
activation energy, ranging from 18.7 to 21.4 kJ.mol-1 according
to the model and compression force employed.
Keywords: Arbutus wild berries (Arbutus unedo L.);
dissolution; electric conductivity; powder; tablet
ABSTRAK
Serbuk lyophilized (LP) dari
Arbutus beri liar Algeria (Arbutus unedo L.) telah
diperoleh. Kertas
ini melaporkan tentang sifat pembubaran
(pelepasan) tablet berasaskan
LP,
dinilai melalui
kekonduksian elektrik (EC)
air suling yang digunakan
sebagai medium kelilling, pada 3 suhu yang berbeza (291, 298 dan 309 K).
Di samping itu, ciri
fizikokimia sekunder
seperti analisis asas, warna dan
kadar mampatan
telah dinilai.
Mengenai model pemindahan ionik, antara tiga
model yang diuji ialah
Peleg, Singh et al. dan Singh dan
Kulshestha, dengan
yang terakhir paling sesuai (R2
= 0,99), terutamanya
dalam kes tablet yang dipadatkan di bawah 2000 Pa.
Pergantungan suhu dalam proses pembubaran juga dikaji menggunakan
persamaan Arrhenius (R2>
0.8) yang dibenarkan untuk
menyimpulkan tenaga pengaktifan, antara 18.7 hingga 21.4 kJ.mol-1 mengikut
model dan mampatan
daya yang digunakan.
Kata kunci: Arbutus beri liar (Arbutus unedo L.); kekonduksian elektrik; pembubaran; serbuk; tablet
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*Corresponding author; email: sbenamara2001@yahoo.fr
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