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Sains Malaysiana 46(9)(2017):
1471–1477
http://dx.doi.org/10.17576/jsm-2017-4609-16
Gynura procumbens Leaf
Improves Blood Glucose Level, Restores Fertility and Libido of Diabetic-Induced
Male Rats
(Daun Gynura procumbens Meningkatkan Aras Glukosa Darah
serta Memulihkan Kesuburan dan Libido Tikus Jantan Aruhan Diabetik)
KHAIDATUL AKMAR
KAMARUZAMAN
& MAHANEM MAT NOOR*
School of Biosciences and Biotechnology, Faculty
of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi,
Selangor Darul Ehsan, Malaysia
Received: 31 August 2016/Accepted: 1
April 2017
ABSTRACT
Gynura
procumbens (GP) has been widely used in
traditional medicine due to its ability in treating various types of diseases.
This study was carried out to determine the effects of GP on
blood glucose level, fertility and libido of streptozotocin-induced male rats.
A total of 42 male rats were randomly sorted into six groups; normal, negative
and positive controls and three treated groups with different dosages of GP aqueous
extract (GPAE); 150, 300 and 450 mg/kg. Each group was treated via
oral feeding for 14 consecutive days. The rats were sacrificed on day 15 for
further analysis. Administration of GPAE significantly lowered the
fasting blood glucose (FBG) level and increased the plasma
testosterone level of diabetic-induced rats compared to the positive and
negative control groups. There was also a significant increase in the sperm
quality as well as the fertility of GPAE treated groups compared to
the negative and positive control groups. Sexual behaviour analysis
demonstrated that GPAE is able to facilitate the
expression of sexual behaviour significantly; increased mounting frequency and
reduced mounting latency. These lines of evidence suggested that GPAE can act as antihyperglycaemic, profertility and libido agents.
However, its mechanism(s) remains unresolved.
Keywords:
Diabetic; fertility; Gynura procumbens; sexual behaviour; testosterone
ABSTRAK
Gynura procumbens
(GP) telah digunakan
secara meluas
dalam perubatan tradisional kerana keupayaannya dalam merawat pelbagai jenis penyakit. Kajian ini telah dijalankan
untuk menentukan
kesan GP ke atas aras
glukosa darah,
kesuburan dan libido tikus jantan yang diaruh streptozotocin. Sejumlah 42 ekor tikus jantan
telah diasingkan
secara rawak kepada
enam kumpulan;
kawalan normal, negatif dan positif serta
tiga kumpulan
yang dirawat dengan dos berbeza ekstrak akues GP (GPAE);
150, 300 dan 450 mg/kg. Setiap kumpulan
diberi perlakuan
secara oral selama 14 hari berturut-turut. Tikus dikorbankan
pada hari ke-15 untuk
analisis lanjut. Perlakuan GPAE dengan
signifikan telah
menurunkan tahap glukosa darah berpuasa
(FBG)
dan meningkatkan
aras testosteron
plasma tikus diaruh
diabetes berbanding dengan
kumpulan kawalan positif dan negatif.
Terdapat
juga peningkatan signifikan
dalam kualiti
sperma serta kesuburan
kumpulan rawatan
GPAE
berbanding dengan
kumpulan kawalan
negatif dan positif.
Kajian
kelakuan seksual menunjukkan bahawa GPAE
ini dapat
meningkatkan kelakuan seksual dengan signifikan; meningkatkan kekerapan pemanjatan dan mengurangkan tempoh pendam pemanjatan.
Bukti
ini mencadangkan bahawa GPAE boleh
bertindak sebagai agen anti hiperglisemik, prokesuburan dan libido.
Walau bagaimanapun mekanisme ini masih belum
diketahui. Kata kunci: Diabetis melitus; Gynura procumbens; kelakuan seksual; kesuburan; testosteron REFERENCES
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*Corresponding author; email: mahanem@ukm.edu.my |
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