Sains Malaysiana 47(10)(2018): 2359–2368

http://dx.doi.org/10.17576/jsm-2018-4710-12

 

Piper sarmentosum as an Antioxidant: A Systematic Review

(Piper sarmentosum sebagai Antioksidan: Ulasan Sistematik)

 

SITI MARJIANA ISMAIL1,2, CHUA KIEN HUI1, AMILIA AMINUDDIN1 & AZIZAH UGUSMAN1*

 

1Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

2Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

 

Received: 31 March 2018/Accepted: 5 June 2018

 

ABSTRACT

Piper sarmentosum (PS) is an herb with various medicinal properties. The antioxidant activity of PS contributes to many of its pharmacological effects such as anti-hypertension, anti-cancer and anti-diabetes. This systematic review provides information regarding the antioxidant activity of PS. The review was conducted systematically to identify relevant published articles on the antioxidant activity of PS. The collected data was based on the searched articles through PubMed, Science Direct and Scopus databases between the years 1946 until March 2018. Only articles written in English and related to antioxidant activity of PS were included in this review. Based on the literature searched, 130 potential articles were identified and 19 articles met the inclusion criteria. Ten studies related to chemical assays, five studies combined in vivo animal and chemical assays, three studies combined chemical assays and in vitro studies and a single study combined chemical assay, in vitro and in vivo studies were included in this review. All studies showed positive effects of PS against oxidation, indicating the potential of PS as a source of natural antioxidant.

 

Keywords: Antioxidant; free radicals; free radical scavenging effect; oxidative stress; Piper sarmentosum

 

ABSTRAK

Piper sarmentosum (PS) merupakan sejenis herba yang mempunyai pelbagai manfaat daripada segi perubatan. Aktiviti antioksidan PS banyak menyumbang kepada kesan farmakologinya seperti anti-hipertensi, anti-kanser dan anti-diabetes. Ulasan sistematik ini menyediakan maklumat berkenaan aktiviti antioksidan PS. Ulasan dilakukan secara sistematik untuk mengenal pasti penerbitan yang berkaitan dengan aktiviti antioksidan PS. Data yang dikumpul adalah berdasarkan artikel yang dicari melalui pangkalan data PubMed, Science Direct dan Scopus antara tahun 1946 sehingga Mac 2018. Artikel berbahasa Inggeris yang berkaitan dengan aktiviti antioksidan PS dimasukkan ke dalam ulasan ini. Berdasarkan pencarian, sebanyak 130 artikel yang berpotensi telah dikenal pasti dan 19 artikel memenuhi kriteria inklusif kajian. Sebanyak sepuluh kajian asai kimia, lima kajian gabungan kajian asai kimia dan kajian in vivo, tiga kajian gabungan kajian asai kimia dan kajian in vitro dan satu kajian hasil gabungan asai kimia, kajian in vivo dan kajian in vitro terpilih di dalam ulasan ini. Kesemua kajian menunjukkan kesan positif PS terhadap pengoksidaan dan ini menandakan PS berpotensi sebagai sumber antioksidan semula jadi.

 

Kata kunci: Antioksidan; kesan pengaruh radikal bebas; Piper sarmentosum; radikal bebas; stres oksidatif

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*Corresponding author; email: dr.azizah@ppukm.ukm.edu.my

 

 

 

 

 

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