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Sains Malaysiana 47(4)(2018): 749-754 http://dx.doi.org/10.17576/jsm-2018-4704-13
Synthesis of Cephradine Metal Complexes
and its Anti-bacterial Evaluation
(Sintesis Kompleks Logam Sefradin dan Penilaian
Anti-bakteria)
IQBAL HUSSAIN1, SYED SALMAN1, SARWAT IFTIKHAR2, SAMIN JAN2, JUNAID AKHTER3, MUHAMMAD RAMZAN1, ATTA ULLAH4, RIAZ ULLAH5,6*, MANSOUR S. ALSAID5,6, ABDELAATY A. SHAHAT5,7 & SYED HIDAYATULLA5,6
1Department of Chemistry, Islamia College Peshawar Jamrud Road, Peshawar, 25120 Pakistan
2Department of Botany Islamia College Peshawar, Jamrud Road, Peshawar, 25120 Pakistan
3Department of Chemistry, Kohat University of Science & Technology, Kohat Pakistan, 26000 Khyber Pakhtunkhwa Pakistan
4Department of
Chemistry Islamia College, Peshawar Jamrud Road,, Peshawar, 25120 Pakistan
5Department of Pharmacognosy and Medicinal, Aromatic & Poisonous Plants Research Center MAPPRC) College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451 Saudi Arabia
6Department of Chemistry Government College Ara Khel FR Kohat, KPK, Pakistan
7Phytochemistry Department, National Research Centre 33 El Bohouth st. P.O. Box 12622 Dokki, Giza Egypt
Received: 19 April 2017/Accepted: 11 November 2017
ABSTRACT
Cephradine
belongs to the first generation cephalosporin having a broad range of
anti-bacterial activities. In the present work, Cephradine wasreacted with different metal salts. These metal salts were Iron, Copper, Cobalt and Nickel salts. All the complexes of
Cephradine metals were synthesized at room temperature using a mechanical
vibrator. The reactions yielded the
coordinated complexes within 5-10 min with improved product yield. The
synthesized complexes were analyzed for their antibacterial power using disc diffused assay. All the Cephradine complexes showed powerful antibacterial activity. The Co, Cu, Ni and Sn complexes
showed good antibacterial activities 18.5 mm by Cu complexes against S. typhi, 17 mm
against B. subtillus 16.5 mm against S.
aureus, 16 mm against S. coccus. Similarly Sn complexes exhibited 17 mm
zone of inhibition against S. coccus and 15.5 mm against B. subtillus.
Cobalt and Ni complexes also shed significant inhibition activities against
bacterial pathogenic bacterial strains. The study is of particular importance
and new, using mechanical vibrator
for the first time. The product yield is also comparatively good with short
reaction time.
Keywords: Cephalosporin; Cephradine; complexation;
penicillinase; synthesis
ABSTRAK
Sefradin tergolong dalam sefalosporin generasi pertama yang mempunyai pelbagai aktiviti antibakteria. Dalam kertas ini, Sefradin telah menggunakan garam logam yang
berlainan. Garam logam ini adalah besi, tembaga, kobalt dan garam nikel. Semua
kompleks logam Sefradin telah
disintesis pada suhu bilik dengan menggunakan alat vibrator mekanikal. Reaksi
menghasilkan kompleks yang diselaraskan dalam masa 5-10 minit dengan hasil
produk yang lebih baik. Kompleks yang disintesis telah dianalisis untuk kuasa antibakteria mereka menggunakan ujian disebarkan cakera. Semua kompleks Sefradin menunjukkan aktiviti antibakteria yang
kuat. Kompleks Co, Cu, Ni dan Sn menunjukkan aktiviti antibakteria yang baik
18.5 mm oleh kompleks Cu terhadap S.
typhi, 17 mm terhadap B. subtilus 16.5 mm terhadap S. aurius, 16 mm terhadap S. coccus. Begitu juga kompleks Sn mempamerkan zon perencatan 17 mm terhadap S. coccus dan 15.5 mm terhadap B. subtilus. Kobalt dan Ni kompleks juga menimbulkan aktiviti penghambatan yang
ketara terhadap strain bakteria patogenik bakteria. Kajian ini amat penting dan baru serta menggunakan alat vibrator mekanikal untuk kali pertama.
Hasil produk juga agak baik dengan masa reaksi yang pendek.
Kata kunci: Kompleks; penisilinase;
sefalosporin; Sefradin; sintesis
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*Corresponding author; email: rullah@ksu.edu.sa
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