Sains Malaysiana 48(9)(2019): 1899–1906

http://dx.doi.org/10.17576/jsm-2019-4809-10

Chemical Constituents from Stem Bark of Flacourtia rukam Zoll. & Mor. and Their Antioxidant Activities

(Kandungan Kimia daripada Kulit Batang Flacourtia rukam Zoll. & Mor. dan Aktiviti Antioksidannya)

MUHARNI¹, ELFITA¹*, HENI YOHANDINI¹, JULINAR¹, YASRINA² & MIRANTI²

¹Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Indralaya, Ogan Ilir, South Sumatra, 30662, Indonesia

²Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, South Sumatra, 30662, Indonesia

Received: 6 August 2018/Accepted: 9 July 2019

ABSTRACT

Exploration of chemical compounds and biological activities of extract stem bark of Flacourtia rukam have been succesfully. We have isolated and characterized three compounds friedelin (1), poliothrysoside (2), and β-sitosteryl-3β-glucopyranoside (3). The structures were identified used UV, IR and NMR spectrum data and comparison of their NMR data with literature. The antioxidant activities of each of them were tested used DPPH (1,1-diphenyl-2-picryl hydrazyl) method. All compounds givn IC50 value >100 μg/mL and were categorized weaker antioxidant. Compounds 2 and 3 have been reported from other species from genus Flacourtia but this is the first report of the isolation from F. rukam.

Keywords: Antioxidant; β-sitosteryl-3β-glucopyranoside; Flacourtia rukam; friedelin; poliothrysoside

ABSTRAK

Penerokaan sebatian kimia dan aktiviti biologi ekstrak kulit batang Flacourtia rukam telah berjaya. Kami telah dapat mengasingkan dan mencirikan tiga sebatian friedelin (1), poliotrysoside (2), dan β-sitosteril-3β-glukopyranoside (3). Struktur telah dikenal pasti menggunakan data spektrum UV, IR dan NMR dan perbandingan data NMR mereka dengan data kepustakaan. Kegiatan antioksidan masing-masing diuji menggunakan kaedah DPPH (1,1-difenil-2-pikril hidrazil). Semua sebatian mengandungi nilai IC50>100 μg/mL dan dikategorikan sebagai antioksida yang lemah. Sebatian 2 dan 3 telah dilaporkan daripada spesies lain daripada genus Flacourtia tetapi ini adalah laporan pertama pengasingan daripada F. rukam.

Kata kunci: Antioksidan; Flacourtia rukam; friedelin; poliotrisosida; β-sitosteril-3β-glukopiranosida

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*Corresponding author; email: elfita69@gmail.com