Sains Malaysiana 49(6)(2020): 1351-1358

http://dx.doi.org/10.17576/jsm-2020-4906-13

Role of Novel Therapeutic Agents in Modulating Invadopodia Formation in Metastatic Breast Cancer

(Peranan Agen Terapi Baru dalam Memodulasikan Pembentukan Invadopodia dalam Kanser Payudara Metastatik)

SITI NOR AINI HARUN¹, NURUL AKMARYANTI ABDULLAH¹, NORAINA MUHAMAD ZAKUAN¹, HAFIZAH ABDUL HAMID¹, MUHAMMAD ZULFADLI MEHAT² & NUR FARIESHA MD HASHIM¹*

¹Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia

²Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia

Received: 12 July 2019/Accepted: 11 February 2020

ABSTRACT

The ability to colonize distant organs which is lethal has made metastatic breast cancer become the top ten causes of mortality worldwide. Specialized actin-rich protrusions termed invadopodia were thought to be formed by highly invasive cells to degrade the extracellular matrix to drive cancer invasion and metastasis. Identification of compound(s) to hinder the formation ofinvadopodia is important to resist the metastasis of breast cancer as well as to yield anti-metastasis targeted therapy. The current review aims to provide new insights on cancer invasion and candidate compound(s) capable to disrupt invadopodia formation and invadopodia-related proteins.

Keywords: Cancer invasion; invadopodia; metastatic breast cancer

ABSTRAK

Keupayaan untuk merebak ke organ lain telah menjadikan kanser payudara metastatik antara puluhan penyebab kematian di seluruh dunia. Protusi khusus diperkaya-aktin ataupun invadopodia dikatakan terbentuk daripada sel-sel yang invasif sehingga mendegradasi matriks ekstrasel yang seterusnya mendorong kepada serangan kanser dan metastasis. Pengenalpastian kompaun untuk menghalang pembentukan invadopodia adalah penting untuk menentang kanser payudara metastatik serta mencari terapi sasaran anti-metastatik. Ulasan ini bertujuan untuk memberikan pandangan baru mengenai serangan kanser dan kompaun yang berkemungkinan menghalang pembentukan invadopodia dan protein berkaitan dengan invadopodia.

Kata kunci: Invadopodia; kanser payudara metastatik; serangan kanser

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*Corresponding author; email: nurfariesha@upm.edu.my