 |
 |
 |
 |
 |
 |
Sains Malaysiana 50(2)(2021): 419-428
http://dx.doi.org/10.17576/jsm-2021-5002-13
Age Estimation using Aorta Image Analysis in the
Thai Population
(Penganggaran Usia menggunakan Analisis Imej Aorta dalam Populasi Thai)
PORNHATAI KOMUTRATTANANONT1, TREERAT GUMPANGSETH1,
PARISON PALEE2, SUKON PRASITWATTANASEREE3, NORZANA ABD
GHAFAR4, CHATURONG KANCHAI5 & PASUK MAHAKKANUKRAUH6,7,8*
1Faculty of
Medicine, Chiang Mai University, Chiang Mai, 52000, Thailand
2College
of Arts, Media and Technology, Chiang Mai University, Chiang Mai, 50200, Thailand
3Department
of Statistics, Faculty of Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand
4Department
of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia
5Department of Forensic Medicine,
Faculty of Medicine,
Chiang Mai University,
Chiang Mai, 50200 6Department
of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 52000, Thailand
7Forensic Osteology Research Center, Faculty of Medicine, Chiang
Mai University, Chiang Mai, 50200, Thailand
8Excellence in Osteology Research
and Training Center (ORTC), Chiang Mai University, Chiang Mai, 50200, Thailand
Received: 4 October
2019/Accepted: 3 August 2020
ABSTRACT
The
current technology used in imaging has an increasing role in medical education.
The concept of using an image analysis programme to help in estimating the age of
the aorta, the largest artery, can be clearly seen to be of use, especially in
establishing age changes for the identification of individuals. The purposes of
the study were to investigate gross morphology, morphometric parameters, and
the correlation between parameters with age of the aorta in human cadavers by
using an image analysis programme. A total of 244 specimens were dissected from 4
locations of 61 human aortas from donour and autopsy cadavers with an age range
of 20 to 90 years. The morphometric parameters included outer circumference,
inner circumference, aortic diameter, and average thickness of all locations of
the aorta. These were defined and measured by using the image analysis programme.
The results of this study showed that the outer circumference (r=0.808-0.739), inner circumference (r=0.763-0.682), vertical diameter of the aorta (r=0.628-0.524) and horizontal diameter of the aorta (r=0.808-0.396) showed a significant correlation with
age in all areas of the aorta. In the ascending aorta, the correlation
between the outer circumference, horizontal diameter and age were higher
than other variables and areas. The age equation established
pertinent to the outer circumference (OC) in the ascending aorta was age = -61.648+ (1.141(OC)) with a standard error of ± 12.45 years. The age prediction equation for the horizontal diameter (HD) in the
ascending aorta was age = -35.799+ (4.134(HD)) and a standard error of ± 12.43
years. In conclusion, knowledge of the structural changes associated with age
can be used for age estimation in forensic anthropology.
Keywords:
Age changes; aorta; estimation of age; geometry; image analysis
ABSTRAK
Peranan teknologi pengimejan menunjukkan peningkatan yang tinggi dalam pendidikan perubatan. Konsep penggunaan program analisis imej untuk membantu penganggaran usia aorta, arteri terbesar, dapat dilihat dengan jelas dalam penggunaannya, terutama pada
zaman membangun ini untuk mengenal pasti individu. Tujuan penyelidikan ini adalah untuk mengkaji morfologi gros, parameter morfometri dan kaitannya dengan usia aorta dalam badan manusia dengan menggunakan program analisis pengimejan. Sejumlah 244 spesimen dibelah dua daripada 4 tempat daripada 61 penderma aorta dan juga autopsi mayat dengan umur antara 20 hingga 90 tahun. Parameter morfometri termasuk lilitan luar, lilitan dalam,
diameter aorta dan purata tebal aorta di semua lokasi.
Nilai tersebut diperincikan dan diukur dengan menggunakan program analisis pengimejan. Hasil kajian ini menunjukkan bahawa lilitan luaran (r=0.808-0.739), lilitan dalaman (r=0.763-0.682), diameter sudut tegak aorta (r=0.628-0.524) dan diameter sudut mengufuk aorta
(r=0.808-0.396) menunjukkan bahawa terdapat kaitan yang ketara dengan umur pada kesemua kawasan aorta.
Pada aorta menaik, hubungan antara lilitan luaran, diameter sudut mengufuk dan usia adalah lebih tinggi jika dibandingkan dengan pemboleh ubah daripada kawasan yang lain. Persamaan usia telah menunjukkan bahawa ia berkait dengan lilitan luar (OC) dalam aorta menaik pada usia = -61.648+
(1.141(OC)) dengan ralat piawai ± 12.45 tahun. Kesimpulannya, ilmu berkaitan dengan perubahan struktur yang berkait dengan usia dapat digunakan untuk menganggar usia dalam forensik antropologi.
Kata kunci: Analisis imej; aorta; geometri; perubahan usia; penganggaran usia
REFERENCES
Abdallah, Y.M.Y. & Alqahtani,
T. 2019. Research in Medical Imaging using Image Processing Techniques. Yongxia
Zhou: IntechOpen.
Alkass,
K., Buchholz, B.A., Ohtani, S., Yamamoto, T., Druid, H. & Spalding, K.L.
2010. Age estimation in forensic sciences: Application of combined aspartic
acid racemization and radiocarbon analysis. Molecular
& Cellular Proteomics 9(5):
1022-1030.
Bootpheaw,
T. 2014. Normal abdominal aortic diameter in the southern Thai population by
multidetector computed tomography. Department
of Medical Services Journal 39(2).
Brandes,
R.P., Fleming, I. & Busse, R. 2005. Endothelial aging. Cardiovascular Research 66(2):
286-294.
Dixon,
A., Lawrence, J. & Mitchell, J. 1984. Age-related changes in the abdominal
aorta shown by computed tomography. Clinical
Radiology 35(1): 33-37.
Euathrongchit,
J., Deesuwan, P., Kuanprasert, S. & Woragitpoopol, S. 2009. Normal thoracic
aortic diameter in Thai people by multidetector computed tomography. Medical Journal of the Medical Association
of Thailand 92(2): 236-242.
Franklin,
D. 2010. Forensic age estimation in human skeletal remains: Current concepts
and future directions. Legal Medicine 12(1): 1-7.
Garcier,
J.M., Petitcolin, V., Filaire, M., Mofid, R., Azarnouch, K., Ravel, A.,
Vanneuville, G. & Boyer, L. 2003. Normal diameter of the thoracic aorta in
adults: A magnetic resonance imaging study. Surgical
and Radiologic Anatomy 25(3-4):
322-329.
Gartner,
L.P. & Hiatt, J.L. 2012. Color Atlas
and Text of Histology. 6th ed. Baltimore: Lippincott Williams &
Wilkins.
Griffin,
R., Moody, H., Penkman, K. & Collins, M. 2008. The application of amino
acid racemization in the acid soluble fraction of enamel to the estimation of
the age of human teeth. Forensic Science
International 175(1): 11-16.
Hager,
A., Kaemmerer, H., Rapp-Bernhardt, U., Blücher, S., Rapp, K., Bernhardt, T.M.,
Galanski, M. & Hess, J. 2002. Diameters of the thoracic aorta throughout
life as measured with helical computed tomography. The Journal of Thoracic and Cardiovascular Surgery 123(6): 1060-1066.
Hickson,
S.S., Butlin, M., Graves, M., Taviani, V., Avolio, A.P., McEniery, C.M. &
Wilkinson, I.B. 2010. The relationship of age with regional aortic stiffness
and diameter. JACC: Cardiovascular
Imaging 3(12): 1247-1255.
Izzo
Jr., J.L. & Shykoff, B.E. 2001. Arterial stiffness: Clinical relevance,
measurement, and treatment. Reviews in
Cardiovascular Medicine 2(1):
29-40.
Lakatta,
E.G. & Levy, D. 2003a. Arterial and cardiac aging: Major shareholders in
cardiovascular disease enterprises: Part I: aging arteries: A “set up” for
vascular disease. Circulation 107(1): 139-146.
Lakatta,
E.G. & Levy, D. 2003b. Arterial and cardiac aging: Major shareholders in
cardiovascular disease enterprises: Part II: the aging heart in health: Links
to heart disease. Circulation 107(2): 346-354.
Lanne,
T., Sonesson, B., Bergqvist, D., Bengtsson, H. & Gustafsson, D. 1992.
Diameter and compliance in the male human abdominal aorta: Influence of age and
aortic aneurysm. European Journal of
Vascular Surgery 6(2):
178-184.
Laurent,
S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D.,
Pannier, B., Vlachopoulos, C., Wilkinson, I. & Struijker-Boudier, H. 2006. Expert consensus document on arterial stiffness:
Methodological issues and clinical applications. European Heart Journal 27(21):
2588-2605.
Lee,
S.H., Lee, W., Choi, H.J., Kim, D.J., Park, E.A., Chung, J.W. & Park, J.H.
2013. Measurement of the aortic diameter in the asymptomatic Korean population:
Assessment with multidetector CT. Journal
of the Korean Society of Radiology 69(2):
105-112.
Lynnerup,
N. 2013. Forensic anthropology and human identification. Scandinavian Journal of Forensic Science 19(1): 16-38.
Mitchell,
G.F., Hwang, S.J., Vasan, R.S., Larson, M.G., Pencina, M.J., Hamburg, N.M.,
Vita, J.A., Levy, D. & Benjamin, E.J. 2010. Arterial stiffness and
cardiovascular events: The Framingham heart study. Circulation 121(4):
505-511.
Nichols,
W.W. 2011. McDonald's Blood Flow in Arteries: Theoretical, Experimental and
Clinical Principles. 6th ed. London: Hodder Arnold.
Ohyama,
Y., Redheuil, A., Kachenoura, N., Ambale Venkatesh, B. & Lima, J.A.C. 2018.
Imaging insights on the aorta in aging. Circulation:
Cardiovascular Imaging 11(4):
e005617-e005617.
Prapaisilp,
P. 2016. Measurement of the aortic diameter in the asymptomatic Thai population
in Siriraj Hospital: Assessment with multidetector CT. Siriraj Medical Journal 68(4):
247-256.
Ritz-Timme,
S., Cattaneo, C., Collins, M., Waite, E., Schütz, H., Kaatsch, H.J. &
Borrman, H. 2000. Age estimation: The state of the art in relation to the
specific demands of forensic practise. International
Journal of Legal Medicine 113(3):
129-136.
Rizzo,
R.J., McCarthy, W.J., Dixit, S.N., Lilly, M.P., Shively, V.P., Flinn, W.R.
& Yao, J.S. 1989. Collagen types and matrix protein content in human
abdominal aortic aneurysms. Journal of
Vascular Surgery 10(4):
365-373.
Saukko,
P. & Knight, B. 2015. Knight's
Forensic Pathology. 4th ed. New York: CRC Press.
Sawabe,
M., Hamamatsu, A., Chida, K., Mieno, M.N. & Ozawa, T. 2011. Age is a major
pathobiological determinant of aortic dilatation: A large autopsy study of
community deaths. Journal of
Atherosclerosis and Thrombosis 18(2):
157-165.
Silva,
E.S., Rodrigues Jr,, A.J., de Tolosa, E.M.C., Pereira, P.R.B., Zanoto, A. &
Martins, J. 1999. Variation of infrarenal aortic diameter: A necropsy study. Journal of Vascular Surgery 29(5): 920-927.
Sonesson,
B., Länne, T., Hansen, F. & Sandgren, T. 1994. Infrarenal aortic diameter
in the healthy person. European Journal
of Vascular Surgery 8(1):
89-95.
Vlachopoulos,
C., Aznaouridis, K. & Stefanadis, C. 2010. Prediction of cardiovascular
events and all-cause mortality with arterial stiffness: A systematic review and
meta-analysis. Journal of the American College
of Cardiology 55(13):
1318-1327.
Wolak,
A., Gransar, H., Thomson, L.E., Friedman, J.D., Hachamovitch, R., Gutstein, A.,
Shaw, L.J., Polk, D., Wong, N.D., Saouaf, R. & Hayes, S.W. 2008. Aortic
size assessment by noncontrast cardiac computed tomography: Normal limits by
age, gender, and body surface area. JACC:
Cardiovascular Imaging 1(2):
200-209.
*Corresponding author; email: pasuk034@gmail.com
|
|||
|
