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Sains Malaysiana 42(10)(2013): 1511–1516
Anti-inflammatory
Effects of Labisia pumila (Blume) F. Vill-Naves. Aqueous Extract
(Kesan
Ekstrak Larutan Labisia pumila (Blume) F. Vill-Naves. Sebagai
Anti-radang)
R.A.M. Sanusi1, N.A. Ab Shukor2* 1Faculty of Forestry, Universiti Putra Malaysia,
43400 UPM,
Serdang, Selangor, Malaysia
Diserahkan: 13 April 2013/Diterima: 12 Mei 2013
ABSTRACT
This study was carried out to evaluate the anti-inflammatory
effects of three concentrations of Labisia pumila (Blume) F. Vill-Naves aqueous leaf extract in
rats. The effects of these extracts as anti-inflammatory agents were determined
using two experiments namely formalin-induced paw licking and
carrageenan-induced paw oedema test. The exposure of inflammation to various
treatments resulted in significant differences between treatments in
formalin-induced paw licking in rats experiment whereas in phase 2, 50 mg kg-1 of L. pumila extract showed the most significant inhibition of 82.12%,
followed by 10 mg kg-1 with 76.00% and 25 mg kg-1 with 57.80%.
Similarly, different treatments showed significant effects at p<0.05
in the carrageenan inducing paw oedema experiment. All treatments were able to
suppress the oedema formation induced by carrageenan as compared with the
control. It is evident that the anti-inflammtory effect of every concentration
of L. pumila extract started
as early as the first hour of carrageenan injection and showed the maximum
inhibition during the fifth hour. Again, 50 mg kg-1 of L. pumila extract
was found to be the best treatment that could reduce inflammation with highest
inhibition of 64.59% followed by 25 mg kg-1 with 56.99% and 10 mg kg-1 with
5.55%. The result of this study has shown that these extracts of L. pumila can be effective for anti-inflammation
purposes which supports and justifies traditional uses of this plant.
Keywords: Anti-inflammation; carrageenan induce paw oedema test;
formalin-induced paw licking test; Labisia pumila; medicinal plants
ABSTRAK
Kajian ini telah dijalankan untuk menilai kesan tiga kepekatan
ekstrak larutan Labisia pumila sebagai
anti-radang ke atas tikus. Kesan ekstrak sebagai anti-radang dikenal pasti
melalui uji kaji formalin yang menyebabkan tikus menjilat tapak kaki dan
karaginan yang menyebabkan kebengkakan pada tapak kaki. Kesan rawatan terhadap
keradangan menunjukkan perbezaan bererti dalam pengurangan radang di dalam uji
kaji formalin dan di dalam fasa 2, 50 mg kg-1 ekstrak L. pumila menunjukkan
kesan pengurangan paling bererti sebanyak 82.12%, diikuti 10 mg kg-1 dengan
76.00% dan 25 mg kg-1 dengan 57.80%. Rawatan yang berbeza juga
memberikan kesan yang bererti pada p<0.05 di dalam uji kaji karaginan
yang menyebabkan kebengkakan tapak kaki. Semua rawatan yang diberikan dapat
mengurangkan kebengkakan yang disebabkan oleh karaginan jika dibandingkan
dengan kawalan. Adalah terbukti bahawa kesan anti-radang dalam setiap kepekatan
ekstrak L. pumila bermula seawal jam pertama dan memberi kesan maksimum
dalam pengurangan radang semasa atau pada jam kelima selepas suntikan
karaginan. Sekali lagi kepekatan 50 mg kg-1 merupakan rawatan
terbaik untuk mengurangkan radang dengan peratusan tertinggi sebanyak 64.59%
diikuti dengan 25 mg kg-1 sebanyak 56.99% dan 10 mg kg-1 sebanyak 5.55%.
Keputusan kajian menunjukkan bahawa ekstrak L. pumila adalah berkesan
untuk digunakan sebagai rawatan anti-radang dan ini menyokong penggunaan
tradisi tumbuhan ini.
Kata kunci: Anti-radang; Labisia pumila; tumbuhan ubatan; ujian jilat tapak kaki
rangsangan formalin; ujian kebengkakan tapak kaki rangsangan karaginan
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*Pengarang untuk surat-menyurat; email: anishukor@yahoo.com
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