Sains Malaysiana 42(9)(2013): 1261–1266

 

Xanthones from Calophyllum gracilipes and Their Cytotoxic Activity

(Zanton daripada Calofilum grasilipes dan Aktiviti Ketoksikannya)

 

 

Nadiah Mad Nasir1, Mawardi Rahmani1*, Khozirah Shaari1, Nur Kartinee Kassim1, Rusea Go2, Johnson Stanslas3 & Ethel Jeyaseela Jeyaraj3

1Department of Chemistry, Universiti Putra Malaysia, 43400 UPM, Serdang, Malaysia

  2Department of Biology, Universiti Putra Malaysia, 43400 UPM, Serdang, Malaysia

3Departments of Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor

 

Diserahkan: 14 Disember 2012/Diterima: 11 April 2013

 

ABSTRACT

Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloksanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00 μΜ.

 

Keywords: Calophyllum gracilipes; gracixanton; sterols; trapezifolixanthone; zeyloxanthanone

 

ABSTRAK

Pengekstrakan dan pemisahan kromatografi terhadap ekstrak heksana, klorofom dan metanol kulit batang Calofilum grasilipes telah berjaya memisahkan satu zanton baru, graciksanton (1) dan dua zanton kenali, zeyloksantanon (2) dan trapezifoliksanton (3) bersama dengan tiga sterol biasa, stigmasterol, friedelin dan lupeol. Struktur sebatian ini telah dikenal pasti dengan kaedah analisis spektroskopi dan dibandingkan dengan data spektrum yang terdapat dalam rujukan. Ujian ketoksikan sebatian ini telah ditentukan dan zeyloksantanon (2) menunjukkan aktiviti yang kuat terhadap lima sel dengan nilai IC50 dalam julat 8.00-26.00 μΜ.

 

Kata kunci: Calofilum grasilipes; graciksanton; steros; trapezifoliksanton; zeyloksantanon

 

 

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*Pengarang untuk surat-menyurat; email: mawardi@science.upm.edu.my

 

 

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