Sains Malaysiana 44(3)(2015): 365–370

 

Isolation and Characterization of Styryllactone of Goniothalamus ridleyi

(Pemencilan dan Pencirian Stirillakton Goniothalamus ridleyi)

 

SAMSIAH JUSOH1,4, ZURIATI ZAKARIA2, FASIHUDDIN B. AHMAD3 & LAILY B. DIN4*

 

1Rice and Industrial Crop Research Centre, Malaysian Agricultural Research and Development Institute(MARDI), P.O. Box 12301, 50774 Kuala Lumpur, Malaysia

 

2Malaysia Japan Institute of Technology, Universiti Teknologi Malaysia, 54100 Kuala Lumpur

Malaysia

 

3Department of Chemistry, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

 

4School of Chemical Sciences and Food Technology, Faculty of Science and Technology

Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia

 

 

Diserahkan: 4 Oktober 2013/Diterima: 4 September 2014

 

ABSTRACT

Phytochemical studies were conducted on the stem bark, stem, root and fruit of Goniothalamus ridleyi (Annonaceae) collected at Post Brooke, Gua Musang, Kelantan, Malaysia. Extraction using organic solvent followed by extensive purification using standard procedure afforded an epoxystyryllactone, 5-acetoxyisogoniothalamin oxide (1) from the stem bark and fruit; a styryllactone, 5-acetoxygoniothalamin (2) and a styrylpyrone, dehydrogoniothalamin (3) from the stem and root; a styryllactone, 5-hydroxygoniothalamin (4) from the root and styrylpyrone as well as goniothalamin (5) from the fruit. These compounds were characterized using spectroscopic techniques.

 

Keywords: Annonaceae; goniothalamin derivatives; Goniothalamus; NMR

 

ABSTRAK

Kajian fitokimia telah dijalankan ke atas kulit batang, batang, akar dan buah Goniothalamus ridleyi (Annonaceae) yang diperoleh dari Post Brooke, Gua Musang, Kelantan, Malaysia. Pengekstrakan menggunakan pelarut organik diikuti dengan pemisahan ekstensif menggunakan prosedur piawai menghasilkan epoksistirillakton, 5-asetoksiisogoniotalamin oksida (1) daripada kulit batang dan buah; stirillakton, 5-asetoksigoniotalamin (2) dan stirilpiron, dehidrogoniotalamin (3) daripada batang dan akar; stirillakton, 5-hidroksigoniotalamin (4) daripada akar dan stirilpiron manakala goniotalamin (5) daripada buah. Sebatian-sebatian ini dikenal pasti menggunakan teknik spektroskopi.

 

Kata kunci: Annonaceae; Goniothalamus; NMR; terbitan goniothalamin

RUJUKAN

 

Ee, G.C.L., Lee, H.L. & Goh, S.H. 1999. Larvicidal activity of Malaysian Goniothalamus species. Natural Product Letters 13(2): 137-142.

Fasihuddin, B.A. & Din, L.B. 2002. Isolation and characterization of dehydrogoniothalamin from Goniothalamus umbrosus. Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry 41(7): 1540-1541.

Fasihuddin, B.A., Tukol, W.A., Omar, S. & Sharif, A.M. 1991. 5-acetyl goniothalamin, a styryl dihydropyrone from Goniothalamus uvaroides. Phytochemistry 30(7): 2430-2431.

Goh, S . H . , Ee, G.C. L. & Chuah , C.H. 1995. 5β-Hydroxygoniothalamin, a styrylpyrone derivative from Goniothalamus dolichocarpus (Annonaceae). Natural Product Letters 5: 255-259.

Hasan, C.M., Mia, M.Y., Rashid, M.A. & Connoly, J.D. 1994. 5-acetoxyisogoniothalamin oxide, an epoxystyryl lactone from Goniothalamus sesquipedalis. Phytochemistry 37(6): 1763-1764.

Jewers, K., Davis, J.B., Dougan, J. & Manchanda, A.H. 1972. Goniothalamin and its distribution in four Goniothalamus species. Phytochemistry 11(6): 2025-2030.

Mat-Salleh, K. & Latiff, M.A. 2002. Tumbuhan Ubatan Malaysia. Bangi: Penerbit UKM. p. 112.

Wiart, C. 2007. Goniothalamus species: A source of drugs for the treatment of cancers and bacterial infections? Evidence-Based Complementary and Alternative Medicine 4(3): 299-311.

 

 

*Pengarang untuk surat-menyurat; email: lbdin@ukm.edu.my

 

 

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