Sains Malaysiana 45(7)(2016): 1073–1077

 

Isolation and Identification of Metabolites from the Gram-negative Proteobacteria of Burkholderia cenocepacia and Serratia marcescens

(Pengasingan dan Pengenalpastian Metabolit daripada Proteobakteria Gram-negatif Burkholderia cenocepacia dan Serratia marcescens)

 

ANN-CHEE YAP, KOK-GAN CHAN & YEUN-MUN CHOO*

 

Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Federal Territory, Malaysia

 

Diserahkan: 30 Jun 2015/Diterima: 11 Februari 2016

 

ABSTRACT

Burkholderia cenocepacia and Serratia marcescens are Gram-negative proteobacteria commonly found in the natural environment and are also opportunistic pathogens that caused a number of human diseases. The fermentation culture of Burkholderia cenocepacia yielded three compounds, 4-(2-hydroxyethoxy)-phenol (1), Maculosin (2) and methyl myristate (3). Compound 2 was also isolated together with cyclo(L-Leu-L-Pro) (4) from Serratia marcescens. Compound 1 was isolated from a natural source for the first time and the first isolation of compounds 2-4 was also reported from both Burkholderia cenocepacia and Serratia marcescens.

 

Keywords: Burkholderia cenocepacia; Malaysia microorganism natural products; proteobacteria metabolites; Serratia marcescens

 

ABSTRAK

Burkholderia cenocepacia dan Serratia marcescens adalah proteobakteria Gram-negatif yang biasa dijumpai di alam semula jadi dan juga patogen yang boleh membawa penyakit kepada manusia. Tiga metabolit telah diasingkan daripada kultur fermentasi Burkholderia cenocepacia, iaitu 4-(2-hidroksietoksi)-fenol (1), Maculosin (2) dan metil miristat (3). Sebatian 2 juga diasingkan bersama siklo(L-Leu-L-Pro) (4) daripada Serratia marcescens. Sebatian 1 diasingkan untuk pertama kali daripada sumber hasil semula jadi dan pengasingan untuk sebatian 2-4 juga dilaporkan buat pertama kali daripada Burkholderia cenocepacia dan Serratia marcescens.

 

Kata kunci: Burkholderia cenocepacia; metabolit proteobakteria; sebatian semula jadi mikroorganisme Malaysia; Serratia marcescens

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*Pengarang untuk surat-menyurat; email: ymchoo@um.edu.my

 

 

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