Sains Malaysiana 46(2)(2017): 245–254

http://dx.doi.org/10.17576/jsm-2017-4602-09

Mood, Cognitive Function and Quality of Life Improvements in Middle Aged Women Following Supplementation with Polygonum minus Extract

(Penambahbaikan Mood dan Kualiti Kehidupan dalam Kalangan Wanita Pertengahan

Umur Selepas Pemberian Ekstrak Polygonum minus)

 

HANIS MASTURA YAHYA1*, SUZANA SHAHAR2, SITI NUR ARINA ISMAIL1, AINOR FARAHIN AZIZ1, NORMAH CHE DIN3 & BIBI NABIHAH ABDUL HAKIM2

 

1Nutritional Sciences Programme, School of Healthcare Sciences, Faculty of Health Sciences

Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur,

Wilayah Persekutuan, Malaysia

 

2Dietetics Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Wilayah Persekutuan

Malaysia

 

3Health Psychology Programme, School of Healthcare Sciences, Faculty of Health Sciences

Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Wilayah Persekutuan, Malaysia

 

Diserahkan: 4 Disember 2015/Diterima: 8 Jun 2016

 

ABSTRACT

Polygonum minus is a plant rich in flavonoids and antioxidants beneficial for reducing oxidative stress and lipid peroxidation in neuronal membranes. This randomized, double-blind, placebo-controlled study evaluated the potential benefits of P. minus extract (LineMinusTM) towards improving cognitive function, mood status and quality of life. Thirty five middle-aged women (35-55 years old) were randomized into intervention (n=17) and control group (n=18). Two capsules of P. minus (250 mg) or placebo (100 mg maltodextrin) each were taken once daily for six weeks. Cognitive tests, mood and anthropometric measurements were measured at baseline, week 3 and week 6, whilst biomarkers were measured at baseline and week 6. Parameters related to mood and quality of life including energy/fatigue, social functioning and general health significantly improved from baseline to week 6 in the intervention group (p<0.05). Mean score for cognitive tests (i.e. digit span, comprehensive trail making test (CTMT) and three domains of CNS vital sign (CNSVS)] improved significantly in both intervention and control groups (p<0.05). There was a significant decrease of mean uric acid, estimated glomerular filtration rate (eGFR), total cholesterol and glycated hemoglobin (HbA1C) in the intervention group from baseline to week 6. P. minus supplementation has the potential to improve mood and quality of life and no adverse effects were reported by the participants after 6 weeks supplementation.

 

Keywords: Flavonoid; mood; Polygonum minus; phytochemicals; quality of life; supplement

 

 

ABSTRAK

Polygonum minus adalah tumbuhan yang kaya dengan flavonoid dan antioksidan serta bermanfaat untuk mengurangkan tekanan oksidatif dan peroksidasi lipid pada membran neuron. Kajian ini berbentuk rawak, dwi-buta dan plasebo-terkawal untuk menilai potensi faedah ekstrak P. minus (LineMinusTM) dalam meningkatkan fungsi kognitif, status mood dan kualiti hidup. Tiga puluh lima wanita pertengahan umur (berumur 35-55 tahun) dibahagikan secara rawak ke dalam kumpulan intervensi (n=17) dan kumpulan kawalan (n=18). Dua kapsul P. minus (250 mg) atau plasebo (100 mg maltodekstrin) telah diambil setiap sehari selama enam minggu. Ujian kognitif, mood dan beberapa ukuran antropometri telah diukur pada peringkat dasar, minggu 3 dan minggu 6, manakala penanda biologi diukur pada peringkat dasar dan minggu 6. Parameter yang berkaitan dengan mood dan kualiti hidup termasuk tenaga/keletihan, fungsi sosial dan kesihatan meningkat secara signifikan pada peringkat dasar hingga minggu 6 untuk kumpulan intervensi (p<0.05). Min skor untuk ujian kognitif seperti Digit Span, Comprehensive Trail Making Test (CTMT) dan tiga domain CNS Vital Sign (CNSVS)] meningkat secara signifikan dalam kedua-dua kumpulan intervensi dan kawalan (p<0.05). Terdapat penurunan yang signifikan dalam min asid urik, anggaran kadar penapisan glomerular (EGFR), jumlah kolesterol dan hemoglobin glycated (HbA1C) dalam kumpulan intervensi pada peringkat dasar dan minggu 6. Pemberian P. minus mempunyai potensi untuk memperbaik mood dan kualiti hidup serta tiada kesan buruk dilaporkan oleh peserta selepas pengambilan selama 6 minggu.

 

Kata kunci: Fitokimia; flavonoid; kualiti hidup; mood; Polygonum minus; suplemen

RUJUKAN

Al-Qari, A. 2006. Ensiklopedia Herba-herba Sekeliling Anda. Selangor: Percetakan Zafar Sdn Bhd.

Azlim Almey, A.A., Ahmed Jalal Khan, C., Syed Zahir, I., Mustapha Suleiman, K., ‘Aisyah, M.R. & Kamarul Rahim, K. 2010. Total phenolic content and primary antioxidant activity of methanolic and ethanolic extracts of aromatic plants’ leaves. Intern. Food Res. J. 17: 1077-1084.

Brazier, J., Harper, R., Jones, N.M., O’cathain, A., Thomas, K.J., Usherwood, T. & Westlake, L. 1992. Validating the SF-36 health survey questionnaire: New outcome measure for primary care. Br. Med. J. 305: 160-164.

Cardinal, B.J. & Engels, H.J. 2001. Ginseng does not enhance psychological well-being in healthy, young adults: Results of a double-blind, placebo-controlled, randomised clinical trial. J. Am. Diet. Assoc. 101: 655-660.

Cheah, K., Noorzaleha, S., Lee, H., Son, R., Sabrina, S. & Sim, J. 2008. Comparison of PCR finger printing techniques for the discrimination of Salmonella enteric subsp. enteric Serovarweltevreden isolated from indigenous vegetables in Malaysia. World J. Microb. Biot. 24: 327-335.

Ching, L.S. & Mohamed, S. 2001. Alpha-tocopherol content in 62 edible tropical plants. J. Agric. Food Chem. 49: 3101-3105.

Collie, A., Maruff, P., Darby, D.G. & McStephen, M. 2003. The effects of practice on the cognitive test performance of neurologically normal individuals assessed at brief test-retest intervals. J. Int. Neuropsychol. Soc. 9: 419-428.

Dan, H., Du, W.T. & Fan, X.J. 2011. Study of flavanoids extracted from onion on the blood-brain barrier permeation and neuroprotective effects. Zhongguo Zhong Xi Yi Jie He Za Zhi 31: 1674-1679.

Duff, K., Beglinger, L.J., Schultz, S.K., Moser, D.J., McCaffrey, R.J., Haase, R.F., Westervelt, H.J., Langbehn, D.R. & Paulsen, J.S. 2007. Practice effects in the prediction of long-term cognitive outcome in three patient samples: A novel prognostic index. Arch. Clin. Neuropsychol. 22: 15-24.

Egert, S., Wolffam, S., Bosy-Westphal, A., Boesch-Saadatmandi, C., Wagner, A.E., Frank, J., Rimbach, G. & Mueller, M.J. 2008. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J. Nutr. 138(9): 1615-1621.

Garcia-Garcia, P., Lopez-Munoz, F., Rubio, G., Martin-Agueda, B. & Alamo, C. 2008. Phytotherapy and psychiatry: Bibliometric study of the scientific literature from the last 20 years. Phytomedicine 15: 566-576.

George, A., Ng, C.P., O’Callaghan, M., Jensen, G.S. & Wong, H.J. 2014. In vitro and ex-vivo cellular antioxidant protection and cognitive enhancing effects of an extract of Polygonum minus Huds (Lineminus™) demonstrated in a Barnes Maze animal model for memory and learning. BMC Complement Altern. Med. doi: 10.1186/1472-6882-14-161.

Groth-Marnat, G.E. 2000. Neuropsychological Assessment in Clinical Practice: A Guide to Test Interpretation and Integration. New Jersey: John Wiley & Sons Inc. pp. 129-194.

Gualtieri, C.T. & Johnson, L.G. 2006. Reliability and validity of a computerized neurocognitive test battery, CNS Vital Signs. Arch. Clin. Neuropsychol. 21: 623-643.

Harris, E., Kirk, J., Rowsell, R., Vitetta, L., Sali, A., Scholey, A.B. & Pipingas, A. 2011. The effect of multivitamin supplementation on mood and stress in healthy older men. Hum. Psychopharmacol. 26: 560-567.

Heiman, G.W. 2002. Research Methods in Psychology. 3rd ed. Boston & New York: Houghton Mifflin Company.

Herbal Medicine Research Centre, Institute for Medical Research. 2002. Compendium of medicinal plants used in Malaysia. Vol. 1. Kuala Lumpur: Institute for Medical Research.

Huda-Faujan, N., Noriham, A., Norrakiah, S. & Babji, S. 2009. Antioxidant activity of plants methanolic extracts containing phenolic compounds. Afric. J. Biotech. 8: 484-489.

Ishisaka, A., Ichikawa, S., Sakakibara, H., Piskula, M.K., Nakamura, T., Kato, Y., Ito, M., Miyamoto, K., Tsuji, A., Kawai, Y. & Terao, J. 2011. Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats. Free Radic. Biol. Med. 51: 1329-1336.

Jäger, A.K. & Saaby, L. 2011. Flavonoids and the CNS. Molecules 16: 1471-1485.

Jin, F., Nieman, D.C., Shanely, R.A., Knab, A.M., Austin, M.D. & Sha, W. 2010. The variable plasma quercetin response to 12-week quercetin supplementation in humans. Eur. J. Clin. Nutr. 64(7): 692-697.

Joseph, S., Sugumaran, M. & Kate, L.W.L. 2005. Herbs of Malaysia: An Introduction to the Medicinal, Culinary, Aromatic and Cosmetic Use of Herbs. Selangor: Federal Publications Sdn. Bhd.

Kinrys, G., Coleman, E. & Rothstein, E. 2009. Natural remedies for anxiety disorders: Potential use and clinical applications. Depress Anxiety 26: 259-265.

Lakhan, S.E., & Viera, K.F. 2010. Nutritional and herbal supplements for anxiety and anxiety-related disorders: Systematic review. Nutr. J. 9: 1-14.

Lee, M.H., Lin, R.D., Shen, L.Y., Yang, L.L., Yen, K.Y. & Hou, W.C. 2001. Monamine oxidase B and free radical scavenging activities of natural flavonoids in Melastoma candidum D. Don. J. Agric. Food Chem. 4: 5551-5555.

Maizura, M., Aminah, A. & Wan Aida, W.M. 2011. Total phenolic content and antioxidant activity of kesum (Polygonum minus), ginger (Zingiber officinale) and turmeric (Curcuma longa) extract. Int. Food Res. J. 18: 529-534.

McNair, D.M., Lorr, M. & Droppelman, L.F. 1971. Manual for the Profile of Mood States. San Diego, California: Educational and Industrial Testing Service.

Ming, Y.K., Zulkawi, N.B., Vandana Kotak, C. & Choudhary, Y.K. 2013. Acute and sub-acute oral toxicity of Polygonum minus aqueous extract (Biotropics® Pm101) in wistar rats. Int. J. Pharm Pharm. Sci. 5: 120-124.

Narasimhulu, G. & Mohamed, J. 2014. Medicinal phytochemical and pharmacological properties of kesum (Polygonum minus linn.): A mini review. Int. J. Pharm Pharm. Sci. 6(4): 1-7.

Norliza, M., Elliza, M., Yap, C.S., Nor Syahira, S., Amri, D., Ahmad Fadhil, A., Norazlina, M., Ahmad Nazrun, S., Abdul Salam, B. & Ima Nirwana, S. 2013. Acute and subacute toxicity of Persicaria minor in wistar rats. Asian J. Anim. Sci. 7: 47-55.

Pathak, L., Agrawal, Y. & Dhir, A. 2013. Natural polyphenols in the management of major depression. Expert Opin. Investig. Drugs 22: 863-880.

Qader, S.W., Abdulla, M.A., Chua, L.S. & Hamdan, S. 2012. Potential bioactive property of Polygonum minus Huds (kesum) - Review. Scientific Research and Essays 7: 90-93.

Qader, S.W., Abdulla, M.A., Chua, L.S., Najim, N., Zain, M.M. & Hamdan, S. 2011. Antioxidant, total phenolic content and cytotoxicity evaluation of selected Malaysian plants. Molecules 16: 3433-3443.

Rey, A. 1964. L’Examen Clinique enPsychologie. Paris: Press Universitaire de France.

Reynolds, C.R. 2002. Comprehensive Trail Making Test (CTMT). Austin: Pro-Ed.

Saeed, S.A., Bloch, R.M. & Antonacci, D.J. 2007. Herbal and dietary supplements for treatment of anxiety disorders. Am. Fam. Physician 76: 549-556.

Sayeed, M.S., Shams, T., Hossain, S.F., Rahman, M.R., Mostofa, A.G.M., Kadir, M.F., Mahmood, S. & Asaduzzaman, M. 2014. Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males. J. Ethnopharmacol. 152: 156-162.

Scholey, A., Ossoukhova, A., Owen, L., Ibbara, A., Pipingas, A., He, K., Roller, M. & Stough, C. 2010. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: An acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology (Berl.) 212: 345-356.

Silberstein, R.B., Pipingas, A., Song, J., Camfield, D.A., Nathan, P.J. & Stough, C. 2011. Examining brain-cognition effects of ginkgo biloba extract: Brain activation in the left temporal and left prefrontal cortex in an object working memory task. Evid. Based Complementary Altern. Med. http://dx.doi. org/10.1155/2011/164139.

Spencer, J.P. 2009. Flavonoids and brain health: Multiple effects underpinned by common mechanisms. Genes Nutr. 4: 243- 250.

Sumazian, Y., Ahmad, S., Mansor, H. & Mahmood, M. 2010, Antioxidant activities, flavonoids, ascorbic acid and phenolic content of Malaysian vegetables. J. Med. Plants Res. 4: 881-890.

Suzana, S., Ainor, F.A., Arina, S.N.I., Hanis Mastura, Y., Normah, C.D., Zahara, A.M. & Manal, M.B. 2015. The effect of Polygonum minus extract on cognitive and psychological parameters according to mood status among middle-aged women: A randomised, double-blind, placebo-controlled study. Clin. Interv. Aging 10: 1505-1520.

Tanaka, T. 1976. Tanaka’s Cyclopedia of Edible Plants of the World. Tokyo, Japan: Keigaku Publishing Co. p. 574.

Tildesley, N., Kennedy, D.O., Perry, E.K., Ballard, C.G., Wesnes, K.A. & Scholey, A.B. 2005. Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiol. Behav. 83: 699-709.

Udani, J.K. 2013. Effects of SuperUlam on supporting concentration and mood: A randomised, double-blind, placebo-controlled crossover study. Evid. Based Complementary Altern. Med. doi.org/10.1155/2013/238454.

Urones, G., Sanche, I., Gomez, B. & Basabe, P. 1990. Flavonoids from Polygonum minus. Phytochem. 29: 3687-3689.

Wechsler, D. 1999. Wechsler Abbreviated Scale of Intelligence. The Psychological Corporation: Harcourt Brace & Company, New York.

World Health Organization, WHO. 2004. Promoting mental health: concepts, emerging evidence, practice. http://www. who.intlmentalhealth/evidence/en/promoting mhh.pdf. Accessed 25 May 2015.

 

 

*Pengarang untuk surat-menyurat; email: hanis.yahya@ukm.edu.my

 

 

 

 

 

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