Sains Malaysiana 46(4)(2017): 559–565

http://dx.doi.org/10.17576/jsm-2017-4604-07

 

Survival Study and Prognostic Factors of Ovarian Cancer Registered in a Teaching Hospital in Malaysia

(Kajian Mengenai Kelangsungan Hidup dan Faktor Prognostik bagi Kanser Ovari yang Berdaftar di Hospital Pelatih Perubatan di Malaysia)

 

NAJIHAH LOKMAN*, SITI AZRIN AB. HAMID & NORSA’ADAH BACHOK

 

Unit of Biostatistics and Research Methodology, School of Medical Science, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan Darul Naim, Malaysia

 

Diserahkan: 20 April 2016/Diterima: 13 September 2016

 

ABSTRACT

Ovarian cancer is one of the highest causes of death among female population in Malaysia. A retrospective cohort study among 127 ovarian cancer patients registered in one of the teaching hospital in Malaysia was conducted from 1st January 2002 until 31st December 2011. The objective of this study was to determine the median survival time, five year survival probability and prognostic factors of ovarian cancer patients. Only ovarian cancer patients were selected with strict inclusion and exclusion criteria. Data was analyzed using Kaplan-Meier Survival analysis and Cox proportional hazard regression analysis. The results showed that the overall five-year survival probability of ovarian cancer was 35.2% (95%CI: 26.3, 44.3) with 38 month (95%CI: 25.7, 50.1) median survival time. After adjustment for potential cofounder, significant prognostic factors of ovarian cancer were observed in FIGO stage (HR: 2.53; 1.44, 4.45), loss of appetite (HR: 1.95; 1.23, 3.11) and presence of pleural effusion (HR: 1.98; 1.19, 3.30). Overall, the survival probabilities of ovarian cancer were low and further actions must be taken to improve the survival among advanced cancer patients

 

Keywords: Median survival time; ovarian cancer; prognostic factors; survival probability

 

ABSTRAK

Kanser ovari merupakan salah satu penyebab utama yang membawa kepada kematian dalam kalangan populasi wanita di Malaysia. Satu kajian kohort retrospektif dalam kalangan 127 orang pesakit kanser ovari yang berdaftar di salah sebuah hospital pelatih perubatan di Malaysia telah dijalankan dari 1 Januari 2002 sehingga 31 Disember 2011. Objektif kajian ini adalah untuk mengkaji mengenai tempoh median kelangsungan hidup, keberangkalian kelangsungan hidup untuk lima tahun dan faktor prognostik bagi pesakit kanser ovari. Hanya pesakit kanser ovari dipilih berdasarkan kriteria rangkuman dan penyisihan yang ketat. Data kajian ini dianalisis menggunakan analisis ‘Kaplan-Meier Survival’ dan analisis regresi bahaya berkadaran Cox. Hasil kajian ini menunjukkan bahawa keseluruhan lima tahun kebarangkalian kelangsungan hidup bagi pesakit kanser ovari adalah 35.2% (95%SK: 26.3, 44.3) dengan median kelangsungan hidup selama 38 bulan (95%SK: 25.7, 50.1). Selepas penyesuaian untuk potensi pengasas bersama, faktor prognostik bererti kanser ovari telah diperhatikan pada tahap FIGO (NB: 2.53; 1.44, 4.45), kurang selera makan (HR: 1.95; 1.23, 3.11) dan kehadiran pleural efusi (NB: 1.98; 1.19, 3.30). Secara keseluruhannya, kebarangkalian kelangsungan hidup bagi pesakit kanser ovari di Malaysia adalah rendah dan tindakan selanjutnya mesti dilakukan untuk meningkatkan kelangsungan hidup dalam kalangan pesakit kanser kronik.

 

Kata kunci: Faktor prognostik; kanser ovari; kebarangkalian kelangsungan hidup; median kelangsungan hidup

 

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*Pengarang untuk surat-menyurat; email: jiha1904@gmail.com

 

 

 

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