Sains Malaysiana 47(2)(2018): 323-336

http://dx.doi.org/10.17576/jsm-2018-4702-15

 

Recent Advances in the Use of Animal-Sourced Gelatine as Natural Polymers for Food, Cosmetics and Pharmaceutical Applications

(Kemajuan Terkini dalam Penggunaan Sumber Gelatin Haiwan sebagai Polimer Semula Jadi untuk Aplikasi Makanan, Kosmetik dan Farmaseutik)

 

MOHD SHAKRIE PALAN ABDULLAH1,2, MOHAMED IBRAHIM NOORDIN1, SYED IBRAHIM MOHD ISMAIL3, NUR MURNISA MUSTAPHA4, MALINA JASAMAI5, MOHD FAIRUZ DANIK6, WAN AZMAN WAN ISMAIL6 & AHMAD FUAD SHAMSUDDIN6,7*

 

1Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Federal Territory, Malaysia

 

2Pharmacy Enforcement Branch, Pharmacy Services Division, Kelantan State Health Department, 16100 Kota Bharu, Kelantan Darul Naim, Malaysia

 

3Ain Medicare Sdn. Bhd., Kawasan Perindustrian Pengkalan Chepa 2, 16100 Kota Bharu, Kelantan Darul Naim, Malaysia

 

4Department of Pharmacy, Raja Perempuan Zainab II Hospital, 15100 Kota Bharu, Kelantan Darul Naim, Malaysia

 

5Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Federal Territory, Malaysia

 

6Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Federal Territory, Malaysia

 

7Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur, Royal College of Medicine Perak, (UniKL RCMP), Jalan Greentown, 30450 Ipoh, Perak Darul Ridzuan, Malaysia

 

Diserahkan: 11 Mei 2017/Diterima: 21 Ogos 2017

 

ABSTRACT

Gelatine is used as an excipient for various pharmaceutical dosage forms, such as capsule shells (both hard and soft), tablets, suspensions, emulsions and injections (e.g. plasma expanders). It is also broadly used in various industries such as food and cosmetics. Gelatine is a biopolymer obtained from discarded or unused materials of bovine, porcine, ovine, poultry and marine industrial farms. The discarded materials can be the skin, tendons, cartilages, bones and connective tissues. Gelatine sourced from animals is relatively easy and inexpensive to produce. The potential needs of gelatine cannot be overemphasised. Rising demands, health concerns and religious issues have heightened the need for alternative sources of gelatine. This review presents the various industrial uses of gelatine and the latest developments in producing gelatine from various sources.

 

Keywords: Cosmetics; food; gelatine, injections; pharmaceuticals; plasma expanders

 

ABSTRAK

Gelatin diguna sebagai eksipien (bahan tambahan) dalam pelbagai bentuk dos farmaseutik seperti kelongsong kapsul (keras dan lembut), tablet, ampaian (suspensi), emulsi dan suntikan (contoh: pengembang plasma). Ia juga diguna dalam pelbagai industri lain seperti industri makanan dan kosmetik. Gelatin adalah biopolimer yang diperoleh daripada bahan-bahan terbuang atau yang tidak diguna daripada haiwan ternakan termasuk lembu, porsin, ovin, unggas dan ikan. Bahan-bahan terbuang ini adalah seperti kulit, tendon, rawan, tulang dan tisu penghubung. Gelatin daripada sumber haiwan adalah agak mudah dan murah untuk dihasilkan. Potensi gelatin tidak dapat dinafikan. Permintaan yang semakin meningkat, masalah kesihatan dan isu-isu agama telah meningkatkan keperluan untuk sumber alternatif gelatin. Tinjauan ini membentangkan pelbagai kegunaan gelatin dalam industri dan perkembangan terkini dalam penghasilan gelatin daripada pelbagai sumber.

 

Kata kunci: Farmaseutik; gelatin; kosmetik; makanan; penambah plasma; sumber alternatif

 

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*Pengarang untuk surat-menyurat; email:  fuad.shamsuddin@unikl.edu.my

 

 

 

 

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