The Malaysian Journal of Analytical Sciences Vol 12 No 1 (2008): 251 – 256

 

 

SYNTHESIS AND FLUORESCENCE CHARACTERISTIC OF

    2-SUBSTITUTED AND 6-SUBSTITUTED PURINES

 

Zanariah Abdullah, Maizatul Akmam A. Bakar, Ernie Iryana Awang Din, Nadiah Rifhan Abd. Rani, Noordini

Mohd Salleh, Goh Poh Leong, Liow Pei Ling and Zaharah Aiyub

 

Chemical Synthesis Group, Department of Chemistry,

Faculty of Science, University of Malaya, 50603, Kuala Lumpur

 

Abstract

2-Fluoropurine was prepared from 2–aminopurine through a diazotization reaction, followed by treatment with fluoroboric acid. 2-Aminopurine was obtained from a series of reactions, using  5-nitrouracil as the starting material. 2-Piperidino   and 2- anilinopurines  were  obtained  by  treating  2-fluoropurine  with  piperidine  and  aniline  respectively.  6-Piperidino  and  6- anilinopurines were obtained by treating 6-chloropurine with piperidine and aniline. Fluorescence studies was carried out in various solvents and maximum fluorescence was observed in 75% ethanol. 2-Aminopurine showed the highest fluorescence intensity, followed by 2-anilino and 2-piperidinopurines. 6-Substituted purines showed  stronger  fluorescence intensities compared to 2-substituted purines.

 

Keywords: Fluorescence, purines, synthesis

 

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