The Malaysian Journal of Analytical Sciences Vol 14 No 1 (2010): 1 – 5

 

 

COUMARINS FROM MURRAYA PANICULATA (RUTACEAE)

 

S. S. S. A. Aziz¹, M. A. Sukari²*, M. Rahmani², M. Kitajima³, N. Aimi³, N.J. Ahpandi²

 

¹Faculty of Science and Technology, Universiti Pendidikan Sultan Idris,

35900 Tanjung Malim, Perak Darul Ridzuan.

²Department of Chemistry, Universiti Putra Malaysia,

43400 UPM Serdang, Selangor Darul Ehsan.

³Faculty of Pharmaceutical Science, Chiba University,

1-33 Yayoi-Cho, Inage-Ku, Chiba 263, Japan.

 

*Corresponding author: aspollah@science.upm.edu.my

 

 

Abstract

Phytochemical study on leaves of Murraya paniculata have yielded four coumarins of auraptene (1), trans-gleinadiene (2), 5,7-dimethoxy-8-(3-methyl-2-oxo-butyl)coumarin (3) and toddalenone (4). The compounds were isolated using chromatographic methods and identified using spectroscopic techniques. Antimicrobial activity evaluation on the crude extracts and pure compounds indicated chloroform extracts of the leaves exhibited moderate activity and only gleinadiene (2) showed moderate activity against Bacillus cereus. trans- Isomer of Gleinadiene (2) has never been reported from this plant previously.

 

Keywords : Murraya paniculata; auraptene; gleinadiene; antimicrobial

 

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