The Malaysian Journal of Analytical Sciences Vol 16 No 2 (2012): 103 – 109

 

 

 

SYNTHESIS, STRUCTURAL, ANTIBACTERIAL AND SPECTRAL STUDIES OF Co(II)  COMPLEXES  WITH  SALICYLALDEHYDE  AND p-CHLORO-BENZALDEHYDE 4-PHENYLTHIOSEMICARBAZONE

 

(Sintesis, Penstrukturan, Antibakteria dan Analisis Spektrum Sebatian Kompleks Co(II) dengan Salisilaldehid dan p-klorobenzaldehid 4-feniltiosemikarbazon)

 

Nur Nadia Dzulkifli¹, Yang Farina^1*, Ibrahim Baba¹ and Nazlina Ibrahim²

 

¹School Of Chemical Sciences and Food Technology,

 ²School Of Biosciences and Biotechnology,

Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor

 

*Corresponding author: farina@ukm.my

 

 

Abstract

The Co(II) complexes derived from salicylaldehyde 4-phenylthiosemicarbazone; SaOHtsc, p-chlorobenzaldehyde 4-phenylthiosemicarbazone; ph-HClbtsc is reported and characterized based on elemental analysis, IR, magnetic susceptibility measurement, ¹H and ¹³C NMR spectra.  The Co(II) complexes have the molecular formula CoL₂ where the ligand corresponding to SaOHtsc and ph-HClbtsc.  The elemental analysis for the ligands and complexes were in a good agreement with the theoretical values.  The ligands coordinate to metal ions in different ways which is through mononegative bidentate or dinegative tridentate.  The magnetic susceptibility measurements showed that the CoL₂ complexes with ligand SaOHtsc are diamagnetic thus making this complexes suitable for NMR studies. The signals at the 10.04 ppm were assigned to N²H in the ¹H-NMR spectra of the free ligands was absent in the spectra of the complexes due to the deprotonation of the N²H and coordination to the metal centres. The absence of the band in IR spectrum which is assigned to ν(N²-H) in the spectra of CoL₂ complexes is due to the deprotonation of the ligands upon complexation through azomethine nitrogen and thionic sulphur atom to metal ion.  The thiosemicarbazones and its Co(II) complexes showed moderate inhibitory against bacteria Bacillus Subtilis, Staphylococcus Epidermis, Escherichia Coli and Proteus Mirabilis in 10 μg/disc.

 

Keywords: Thiosemicarbazone, Co(II), antibacterial

 

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