– Functional Genomics

This research area is focused on understanding the molecular basis of common respiratory diseases including asthma, COPD, sleep apnoea and lung cancer. Our current research is centred in defining molecular pathways in various types of inflammatory cells in asthma. We also aim to identify gene signatures that are associated with asthma severity, control status and steroid response. In the lung cancer project, we identify the gene expression profiles that are associated with tumour type, stage and survival. We further define the functions of these genes using RNA interference (RNAi). Understanding of the disease pathways will allow future identification of novel biomarkers and therapeutic targets.