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UKM Medical Molecular Biology Institute

– Infectious Diseases

The laboratory focuses on the two main research areas of dengue and methicillin-resistant Staphylococcus aureus (MRSA).

Our research interests in dengue include the pathogenesis and pathophysiology of dengue, with the aim of developing biomarkers for early prediction of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). We are also investigating the extent of dengue exposure in the Malaysian adult population via a country-wide sampling and detection of dengue antibodies in serum samples. In addition, the laboratory is working with the O & G department on the impact of dengue antibodies in pregnant women and transplacental antibody transfer.

For MRSA and other staphylococci, our research interests focuses on vancomycin resistance in MRSA and VISA (vancomycin-intermediate S. aureus). Pilot studies into the contribution of staphylococcal virulence towards patient clinical outcome are also being carried out. The laboratory works collaboratively with UKMMC Microbiology Department and Infection Control Unit on the molecular epidemiology of Staphylococci sp. isolated in UKMMC, with the objective of controlling staphylococcal transmission and antibiotic resistance in the medical centre.

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