{"id":3809,"date":"2025-10-07T16:58:12","date_gmt":"2025-10-07T08:58:12","guid":{"rendered":"https:\/\/www.ukm.my\/beritaukm\/?p=3809"},"modified":"2025-10-09T16:34:05","modified_gmt":"2025-10-09T08:34:05","slug":"ukm-lecturers-phd-research-at-ucl-uncovers-new-hope-for-broken-heart","status":"publish","type":"post","link":"https:\/\/www.ukm.my\/beritaukm\/ukm-lecturers-phd-research-at-ucl-uncovers-new-hope-for-broken-heart\/","title":{"rendered":"UKM Lecturer’s PHD Research At UCL Uncovers New Hope For Broken Heart"},"content":{"rendered":"\n

By Khairatul Nadia Ramli
Photos by Faculty of Medicine<\/strong><\/p>\n\n\n\n

CHERAS \u2013 A Universiti Kebangsaan Malaysia (UKM) lecturer has contributed to a promising new strategy to protect the heart after a heart attack, offering hope for improved treatment worldwide.<\/p>\n\n\n\n

Dr. Nur Liyana Mohammed Yusof from the Department of Pharmacology, Faculty of Medicine, UKM conducted this research during her PhD in Cardiovascular Sciences at University College London (UCL) in 2024.<\/p>\n\n\n\n

Her work focused on a long-standing challenge in heart attack treatment \u2014 the damage caused when blood flow is restored after a blockage, known as ischaemia-reperfusion (IR) injury.<\/p>\n\n\n\n

\u201cRestoring blood flow is critical, but the sudden rush of oxygen can paradoxically damage the heart and trigger hypercontraction, a destructive process where heart cells contract so forcefully that they burst,\u201d she explained.<\/p>\n\n\n\n

Dr. Nur Liyana discovered that a class of drugs called selective cardiac myosin inhibitors, originally developed for hypertrophic cardiomyopathy, could help reduce this damage.<\/p>\n\n\n\n

These drugs \u2014 mavacamten and aficamten \u2014 have already been approved by the US Food and Drug Administration (FDA) and in the UK for other heart conditions.<\/p>\n\n\n\n

\u201cThis work is a classic example of drug repurposing. We have tested whether these drugs can protect the heart in a completely different scenario \u2013 a heart attack.<\/p>\n\n\n\n

\u201cThe results are very encouraging,\u201d said Dr. Nur Liyana.<\/p>\n\n\n\n

She added that laboratory experiments have shown that the drugs mavacamten and aficamten are able to prevent the hypercontraction of heart cells, with aficamten proving to be particularly effective, even at very low doses.<\/p>\n\n\n\n

\u201cIn animal models, both drugs, administered shortly before blood flow was restored, significantly reduced the size of damaged heart tissue.<\/p>\n\n\n\n

\u201cCrucially, aficamten achieved this without affecting the normal pumping function of the heart in healthy subjects, indicating a large safety margin,\u201d she said.<\/p>\n\n\n\n

While the results are promising, the Dr Nur Liyana emphasized that this is a preclinical phase of study.<\/p>\n\n\n\n

\u201cFurther research is needed to validate these findings in more complex models and ultimately in human clinical trials.<\/p>\n\n\n\n

\u201cIf successful, these drugs could one day be used alongside standard procedures like angioplasty to improve recovery for heart attack patients globally,\u201d she said.<\/p>\n\n\n\n

Dr. Nur Liyana described the project as the cornerstone of her PhD when thinking about her path.<\/p>\n\n\n\n

 \u201cI am keen to continue this research and inspire the next generation of Malaysian scientists. Our findings open up a new way to protect the heart in the critical moments after a heart attack,\u201d she said.<\/p>\n\n\n\n

The research, supported by Yang di-Pertuan Agong Scholarship grant and the British Heart Foundation research grant, was carried out under the direction of Professor Sean M. Davidson and Professor Derek M. Yellon at UCL\u2019s Hatter Cardiovascular Institute.<\/p>\n\n\n\n

The results have been published in two leading journals, Cardiovascular Drugs and Therapy and Basic Research in Cardiology.<\/p>\n\n\n\n

\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"

By Khairatul Nadia RamliPhotos by Faculty of Medicine CHERAS \u2013 A Universiti Kebangsaan Malaysia (UKM) lecturer has contributed to a promising new strategy to protect the heart after a heart… <\/p>\n","protected":false},"author":123457,"featured_media":3817,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-3809","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bahasa-inggeris"],"yoast_head":"\nUKM Lecturer's PHD Research At UCL Uncovers New Hope For Broken Heart - Berita UKM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ukm.my\/beritaukm\/ukm-lecturers-phd-research-at-ucl-uncovers-new-hope-for-broken-heart\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UKM Lecturer's PHD Research At UCL Uncovers New Hope For Broken Heart - 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