Sains Malaysiana 47(4)(2018): 749-754

http://dx.doi.org/10.17576/jsm-2018-4704-13

 

Synthesis of Cephradine Metal Complexes and its Anti-bacterial Evaluation

(Sintesis Kompleks Logam Sefradin dan Penilaian Anti-bakteria)

 

IQBAL HUSSAIN1, SYED SALMAN1, SARWAT IFTIKHAR2, SAMIN JAN2, JUNAID AKHTER3, MUHAMMAD RAMZAN1, ATTA ULLAH4, RIAZ ULLAH5,6*, MANSOUR S. ALSAID5,6 ABDELAATY A. SHAHAT5,7 & SYED HIDAYATHULLA5,6

 

1Department of Chemistry, Islamia College Peshawar Jamrud Road, Peshawar, 25120 Pakistan

 

2Department of Botany Islamia College Peshawar, Jamrud Road, Peshawar, 25120 Pakistan

 

3Department of Chemistry, Kohat University of Science & Technology, Kohat Pakistan,

26000 Khyber Pakhtunkhwa Pakistan

 

4Department of Chemistry Islamia College, Peshawar Jamrud Road,, Peshawar, 25120 Pakistan

 

5Department of Pharmacognosy and Medicinal, Aromatic & Poisonous Plants Research Center MAPPRC) College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451 Saudi Arabia

 

6Department of Chemistry Government College Ara Khel FR Kohat, KPK, Pakistan

 

7Phytochemistry Department, National Research Centre 33 El Bohouth st. P.O. Box 12622

Dokki, Giza Egypt

 

Diserahkan: 19 April 2017/Diterima: 11 November 2017

 

ABSTRACT

 

Cephradine belongs to the first generation cephalosporin having a broad range of anti-bacterial activities. In the present work, Cephradine wasreacted with different metal salts. These metal salts were Iron, Copper, Cobalt and Nickel salts. All the complexes of Cephradine metals were synthesized at room temperature using a mechanical vibrator.  The reactions yielded the coordinated complexes within 5-10 min with improved product yield. The synthesized complexes were analyzed for their antibacterial power using disc diffused assay. All the Cephradine complexes showed powerful antibacterial activity. The Co, Cu, Ni and Sn complexes showed good antibacterial activities 18.5 mm by Cu complexes against S. typhi, 17 mm against B. subtillus 16.5 mm against S. aureus, 16 mm against S. coccus. Similarly Sn complexes exhibited 17 mm zone of inhibition against S. coccus and 15.5 mm against B. subtillus. Cobalt and Ni complexes also shed significant inhibition activities against bacterial pathogenic bacterial strains. The study is of particular importance and new, using mechanical vibrator for the first time. The product yield is also comparatively good with short reaction time.

 

Keywords: Cephalosporin; cephradine; complexation; penicillinase; synthesis

 

 

ABSTRAK

 

Sefradin tergolong dalam sefalosporin generasi pertama yang mempunyai pelbagai aktiviti antibakteria. Dalam kertas ini, Sefradin telah menggunakan garam logam yang berlainan. Garam logam ini adalah besi, tembaga, kobalt dan garam nikel. Semua kompleks logam Sefradin telah disintesis pada suhu bilik dengan menggunakan alat vibrator mekanikal. Reaksi menghasilkan kompleks yang diselaraskan dalam masa 5-10 minit dengan hasil produk yang lebih baik. Kompleks yang disintesis telah dianalisis untuk kuasa antibakteria mereka menggunakan ujian disebarkan cakera. Semua kompleks Sefradin menunjukkan aktiviti antibakteria yang kuat. Kompleks Co, Cu, Ni dan Sn menunjukkan aktiviti antibakteria yang baik 18.5 mm oleh kompleks Cu terhadap S. typhi, 17 mm terhadap B. subtilus 16.5 mm terhadap S. aureus, 16 mm terhadap S. coccus. Begitu juga kompleks Sn mempamerkan zon perencatan 17 mm terhadap S. coccus dan 15.5 mm terhadap B. subtilus. Kobalt dan Ni kompleks juga menimbulkan aktiviti penghambatan yang ketara terhadap strain bakteria patogenik bakteria. Kajian ini amat penting dan baru serta menggunakan alat vibrator mekanikal untuk kali pertama. Hasil produk juga agak baik dengan masa reaksi yang pendek.

 

Kata kunci: Kompleks; penisilinase; sefalosporin; Sefradin; sintesis

 

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*Pengarang untuk surat-menyurat; email: rullah@ksu.edu.sa

 

 

 

 

 

 

 

 

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