Sains Malaysiana 51(10)(2022): 3359-3370


Antihyperglycemic, Antihyperlipidemic, and Antioxidant Effects of Eclipta prostrata L. Aqueous Extract in Streptozotocin-Induced Diabetic Rats

(Kesan Antihiperglisemik, Antihiperlipidemik dan Antioksidan Ekstrak Akueus Eclipta prostrata L. pada Tikus Diabetik Aruhan Streptozotocin)




1Department of Endocrinology, Qinghai Provincial People's Hospital, Xining, Qinghai, 810000, P.R. China

2Department of Endocrinology, Punan Hospital, Pudong New Area, Shanghai, Shanghai, 200125, P.R. China

3Department of Endocrinology, The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu, 222000, P.R. China

4Department of endocrinology and metabolism, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, P.R. China


Diserahkan: 27 November 2021/Diterima: 31 Mei 2022


Equally contributed



With the rising prevalence of diabetes mellitus around the world, researchers have been searching for a new treatment option that is both more effective and safer than chemotherapy. This study evaluated the antidiabetic activities of aqueous extracts of Eclipta prostrataL. in streptozotocin (STZ)-induced diabetic rats.  The rats were randomized into six groups: Normal control, STZ-induced diabetic rats (50 mg/kg), STZ+ EPE (100 mg/kg), STZ + EPE (200 mg/kg), STZ+glibenclamide (600 µg/kg) and EPE alone (200 mg/kg).  The STZ-induced diabetic rats showed significantly (p<0.05) elevated glucose, HbA1c, lipid profile, hepatic, and kidney markers, while significantly (p<0.05) decreased insulin levels. The changes in activities of carbohydrate metabolizing enzymes such as glucose-6-phosphatase, fructose-1,6–bisphosphatase were significantly (p<0.05) increased in diabetic rats, while the activity of glucokinase and glucose-6-phosphate dehydrogenase were significantly (p<0.05) reduced. Oral treatment of STZ-induced diabetic rats with E. prostrata(100 and 200 mg/kg) and glibenclamide (600 µg/kg) prevented the alteration as mentioned earlier and brought back them to near normalcy. The current findings in experimental diabetic rats suggest that oral treatment with E. prostrate ameliorated carbohydrate metabolizing enzymes, showed total cholesterol-lowering effects, improved serum high-density lipoprotein (HDL) cholesterol levels and exhibited intriguing antioxidant activities.


Keywords: Diabetes mellitus; Eclipta prostrata; glucose; insulin



Dengan peningkatan kelaziman diabetes mellitus di seluruh dunia, penyelidik telah mencari pilihan rawatan baharu yang lebih berkesan dan selamat daripada kemoterapi. Kajian ini menilai aktiviti antidiabetik ekstrak akueus Eclipta prostrata L. pada tikus diabetes yang disebabkan oleh streptozotocin (STZ). Tikus telah dibahagikan secara rawak kepada enam kumpulan: Kawalan, tikus diabetes aruhan-STZ (50 mg/kg), STZ + EPE (100 mg/kg), STZ + EPE (200 mg/kg), STZ+glibenclamide (600 µg/ kg) dan EPE sahaja (200 mg/kg). Tikus diabetes aruhan-STZ menunjukkan peningkatan secara signifikan (p<0.05) glukosa, HbA1c, profil lipid, penanda hepar dan buah pinggang, manakala secara signifikan (p<0.05) menurunkan tahap insulin. Perubahan dalam aktiviti enzim metabolisme karbohidrat seperti glukosa-6-fosfatase, fruktosa-1,6-bisphosphatase meningkat dengan ketara (p<0.05) pada tikus diabetes, manakala aktiviti glukokinase dan glukosa-6-fosfat dehidrogenase adalah ketara (p<0.05) berkurangan. Rawatan oral tikus diabetes aruhan-STZ dengan E. prostrata (100 dan 200 mg/kg) dan glibenclamide (600 µg/kg) menghalang pengubahan seperti yang dinyatakan sebelum ini dan membawanya kembali kepada tahap normal. Penemuan dalam uji kaji tikus diabetik ini menunjukkan bahawa rawatan oral dengan E. prostrate memperbaiki enzim metabolisme karbohidrat, menunjukkan kesan penurunan kolesterol secara keseluruhan, meningkatkan paras serum kolesterol lipoprotein berketumpatan tinggi (HDL) dan menunjukkan aktiviti antioksidan yang menarik.


Kata kunci: Diabetes mellitus; Eclipta prostrata; glukosa; insulin



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