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Sains
Malaysiana 51(3)(2022): 733-745
http://doi.org/10.17576/jsm-2022-5103-08
A Comprehensive Review on Chemical
Compounds, Biological Actions and Potential Health Benefits of Stingless Bee Propolis
(Ulasan Komprehensif Komponen Kimia,
Tindakan Biologi dan Potensi Manfaat Kesihatan Propolis Kelulut)
SHARIFAH NUR AMALINA SYED SALLEH, WAN LUTFI WAN JOHARI* & NUR AYUNI MOHD HANAPIAH
Faculty of Forestry and
Environmental Studies, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor
Darul Ehsan, Malaysia
Diserahkan: 19 April 2021/Diterima:
8 Ogos 2021
Abstract
Propolis mainly comprises of resins, waxes, essential oils,
pollens, and impurities collected from various parts of plants such as leaf
buds, mucilage, gums, and lattices. Stingless bees had been noted to produce
higher amount of propolis than honey bees since they use propolis to build
their nests, which makes them valuable and economical. However, very little is
known about the properties of stingless bee propolis compared to honey bees’.
Therefore, this review aims to highlight the chemical composition, biological
actions, health benefits including some promising future research and
directions of stingless bee propolis. Recent studies had shown that the
chemical composition of propolis may vary according to factors such as bee
species, seasonality, location and floral preferences. These compounds play a
major role in the biological and medical efficacy exhibited by the propolis. Stingless
bee propolis is also known to display potent therapeutic and biological
properties such as antioxidant, antimicrobial, antifungal and many more that
could be used to treat diseases, infections and disorders effectively. The
insights provided in this review may helpfully enhance the utility of stingless
bee propolis for their therapeutic and health benefits in the food,
pharmacological and medicinal sectors, some which are yet to be fully
discovered.
Keywords: Biological activity; chemical composition; health
benefit; propolis; stingless bee
Abstrak
Propolis terdiri daripada resin, lilin, minyak pati, debunga
dan campuran yang diambil daripada pelbagai bahagian tumbuhan seperti tunas
daun, lendir, damar dan kekisi. Kelulut dilapor menghasilkan propolis yang
lebih tinggi daripada lebah madu kerana propolisnya digunakan untuk membina
sarang, menjadikan propolis kelulut lebih berharga dan berekonomi. Walau
bagaimanapun, sangat sedikit diketahui tentang propolis kelulut berbanding
lebah madu. Oleh itu, kajian ini menyoroti komposisi kimia, tindakan biologi,
manfaat kesihatan termasuk arah penyelidikan propolis kelulut pada masa
hadapan. Kajian baru telah menunjukkan bahawa komposisi kimia propolis adalah
berbeza mengikut faktor seperti spesies kelulut, musim, lokasi dan pilihan bunga.
Sebatian ini memainkan peranan penting dalam keberkesanan biologi dan perubatan
yang dipamerkan oleh propolis. Propolis kelulut juga dilaporkan mempunyai ciri
terapeutik dan biologi yang berkesan seperti antioksidan, antimikrob, antikulat
dan banyak lagi yang boleh digunakan untuk merawat penyakit, jangkitan serta
gangguan dengan berkesan. Pemahaman yang disediakan dalam ulasan ini diharap
dapat membantu meningkatkan kegunaan propolis kelulut untuk manfaat terapeutik
dan kesihatan dalam sektor makanan, farmakologi dan perubatan yang masih belum
diteroka sepenuhnya.
Kata kunci: Aktiviti biologi; kelulut; komposisi kimia; manfaat kesihatan; propolis
RUJUKAN
Abdullah, N.A., Ja'afar,
F., Yasin, H.M., Taha, H., Petalcorin, M.I.R., Mamit, M.H., Kusrini, E. &
Usman, A. 2019. Physicochemical analyses, antioxidant, antibacterial, and
toxicity of propolis particles produced by stingless bee Heterotrigona itama found in Brunei Darussalam. Heliyon 5(9): 1-8.
Afrouzan, H., Tahghighi,
A., Zakeri, S. & Es-haghi, A. 2018. Chemical composition and antimicrobial
activities of Iranian propolis. Iran
Biomedical Journal 22(1): 50-65.
Agussalim, Umami, N.
& Erwan. 2015. Production of stingless bees (Trigona sp.) propolis in various bee hives design. In The 6th International Seminar on
Tropical Animal Production (ISTAP) Congress: Integrated Approach in Developing
Sustainable Tropical Animal Production. 20-22 October, Yogyakarta.
Ahangari, Z., Naseri, M.
& Vatandoost, F. 2018. Propolis: Chemical composition and its applications
in endodontics. Iranian Endodontic
Journal 13(3): 285-292.
Akhir, R., Bakar, M.
& Sanusi, S. 2017. Antioxidant and antimicrobial activity of stingless bee
bread and propolis extracts. AIP
Conference Proceedings 1891: 1-7.
Al-Fahdawi, I.H. 2015.
Potential indication of propolis in treatment of oral infection for denture
wearers. Journal of Dentistry, Oral
Disorders & Therapy 3(3): 1-3.
Anjum, S.I., Ullah, A., Khan,
K.A., Attaullah, M., Khan, H., Ali, H., Bashir, M.A., Tahir, M., Ansar, M.J.,
Ghramh, H.A., Adgaba, N. & Dash, C.K. 2019. Composition and functional
properties of propolis (bee glue): A review. Saudi Journal of Biological Sciences 26: 1695-1703.
Araújo, M.J.A.M., Bosco,
S.G. & Sforcin, J.M. 2016. Pythium
insidiosum: Inhibitory effects of propolis and geopropolis on hyphal
growth. Brazilian Journal of Microbiology 47(4): 863-869.
Arung, E.T., Syafrizal,
Pasedan, W.F., Tandirogang, N., Sukemi, Allam, A.E., Amen, Y., Shimizu, K.
& Ishikawa, H. 2020. Prenylated flavonoids as antioxidant and melanin
inhibitors from stingless bee (Wallacetrigona
incisa) propolis. Natural Product
Communications 15(3): 1-6.
Balica, G., Vostinaru,
O., Stefanescu, C., Mogosan, C., Iaru, I., Cristina, A. & Pop, C.E. 2021.
Potential role of propolis in the prevention and treatment of metabolic
diseases. Plants 10(5): 1-14.
Bankova, V., Popova, M.
& Trusheva, B. 2014. Propolis volatile compounds: Chemical diversity and
biological activity: A review. Chemistry
Central Journal 8(28): 1-8.
Bazmandegan, G.,
Boroushaki, M.T., Shamsizadeh, A., Ayoobi, F., Hakimizadeh, E. &
Allahtavakoli, M. 2017. Brown propolis attenuates cerebral ischemia-induced
oxidative damage via affecting antioxidant enzyme system in mice. Biomedicine & Pharmacotherapy 85:
503-510.
Brodkiewicz, Y.,
Marcinkevicius, K., Reynoso, M., Salomon, V., Maldonado, L. & Vera, N.
2018. Studies of the biological and therapeutic effects of Argantine stingless
bee propolis. Journal of Drug Delivery
and Therapeutics 8(5): 382-392.
Çelemli, Ö.G. 2012.
Chemical properties of propolis collected by stingless bees. In Pot-Honey, edited by Vit, P., Pedro, S.
& Roubik, D. New York: Springer. pp. 525-537.
Chidi, O.H. & Odo,
P.E. 2017. Meliponiculture for sustainable economy. 133 Proceedings of the 4th Delta State University Faculty of Science
International Conference. pp. 131-137.
Choudhari, M.K.,
Haghniaz, R., Rajwade, J.M. & Paknikar, K.M. 2013. Anticancer activity of
Indian stingless bee propolis: An in
vitro study. Evidence-Based
Complementary and Alternative Medicine 2013: 1-10.
Choudhari, M.K.,
Punekar, S.A., Ranade, R.V. & Paknikar, K.M. 2012. Antimicrobial activity
of stingless bee (Trigona sp.)
propolis used in the folk medicine of Western Maharashtra, India. Journal of Ethnopharmacology 141(1):
363-367.
da Cunha, M.G.,
Franchin, M., de Carvalho Galvão, L.C., de Ruiz, A.L.T.G., de Carvalho,
J.E., Ikegaki, M., de Alencar, S.M., Koo, H. & Rosalen, P.L. 2013.
Antimicrobial and antiproliferative activities of stingless bee Melipona scutellaris geopropolis. BMC Complementary and Alternative Medicine 13(23):
1-9.
de Farias, J.H.C., Reis,
A.S., Araújo, M.A.R., Araújo, M.J.A.M., Assunção, A.K.M., de Farias, J.C.,
Fialho, E.M.S., Silva, L.A., Costa, G.C., Guerra, R.N.M., Ribeiro, M.N.S. &
do Nascimento, F.R.F. 2014. Effects of stingless bee propolis on experimental
asthma. Evidence-Based Complementary and
Alternative Medicine 2014: 951478.
de Souza, E.C., da
Silva, E.J.G., Cordeiro, H.K.C., Filho, N.M.L., da Silva, F.M.A., dos Reis,
D.L.S., Porto, C., Pilau, E.J., da Costa, L.A.M.A., de Souza, A.D.L., Menezes,
C. & Flach, A. 2018. Chemical compositions and antioxidant and
antimicrobial activities of propolis produced by Frieseomelitta longipes and Apis
mellifera bees. Química Nova 41(5): 485-491.
Desamero, M.J., Kakuta,
S., Tang, Y., Chambers, J.K., Uchida, K., Estacio, M.A., Cervancia, C.,
Kominami, Y., Ushio, H., Nakayama, J., Nakayama, H. & Kyuwa, S. 2019.
Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma. Scientific Reports 9(19635): 1-12.
Devequi-Nunes, D.,
Machado, B.A.S., Barreto, G.d.A., Silva, J.R., da Silva, D.F. & da Rocha,
J.L.C. 2018. Chemical characterization and biological activity of six different
extracts of propolis through conventional methods and supercritical extraction. PLoS ONE 13(12): 1-20.
dos Santos, C.M.,
Campos, J.F., dos Santos, H.F., Balestieri, J.B.P., Silva, D.B., Souza, K.P.,
Carollo, C.A., Estevinho, L.M. & dos Santos, E.L. 2017. Chemical
composition and pharmacological effects of geopropolis produced by Melipona quadrifasciata anthidioides. Therapeutic Potential of Natural
Antioxidants 2017: 8320804.
Duailibe, S.A.C.,
Gonçalves, A.G. & Ahid, F.J.M. 2007. Effect of a propolis extract on Streptococcus mutans counts in vivo. Journal of Applied Oral Science 15(5): 420-423.
Farida, S., Sahlan, M.,
Rohmatin, E. & Adawiyah, R. 2020. The beneficial effect of Indonesian
propolis wax from Tetragonula sp. as
a therapy in limited vaginal candidiasis patients. Saudi Journal of Biological Sciences 27(1): 142-146.
Food and Agriculture
Organization of the United Nations (FAO). 2009. Bees and Their Role in Forests Livelihood. fao.org: www.fao.org.
Gargouri, W., Osés,
S.M., Fernández-Muiño, M.A., Sancho, M.T. & Kechaou, N. 2019. Evaluation of
bioactive compounds and biological activities of Tunisian propolis. LWT - Food Science and Technology 11:
328-336.
Georgieva, K., Popova,
M., Dimitrova, L., Trusheva, B., Thanh, L.N., Phuong, D.T.L., Lien, N.T.P.,
Najdenski, H. & Bankova, V. 2019. Phytochemical analysis of Vietnamese
propolis produced by the stingless bee Lisotrigona
cacciae. PLoS ONE 14(4): 1-13.
Ghisalberti, E.L. 1960.
Propolis: A review. Bee World 60:
59-84.
Hasan, A.E.Z.,
Mangunwidjaja, D., Sunarti, T.C., Suparno, O. & Setiyono, A. 2014.
Investigating the antioxidant and anticytotoxic activities of propolis
collected from five regions of Indonesia and their abilities to induce
apoptosis. Emirates Journal of Food and
Agriculture 26(5): 390-398.
Huang, S., Zhang, C.,
Wang, K., Li, G.Q. & Hu, F. 2014. Recent advances in the chemical
composition of propolis. Molecules 19:
19610-19632.
Ibrahim, N., Zakaria,
A.J., Ismail, Z. & Mohd, K.S. 2016. Antibacterial and phenolic content of
propolis produced by two Malaysian stingless bees, Heterotrigona itama and Geniotrigona
thoracica. International Journal of
Pharmacognosy and Phytochemical Research 8(1): 156-161.
Ismail, W.I., Hussin,
N.N., Mazlan, S.N.F., Hussin, N.H. & Mohd Radzi, M.N.F. 2018.
Physicochemical analysis, antioxidant and anti-proliferation activities of
honey, propolis and beebread harvested from stingless bee. IOP Conf. Series: Materials Science and Engineering 440: 1-7.
Jalil, M.A.A., Kasmuri,
A.R. & Hadi, H. 2017. stingless bee honey, the natural wound healer: A
review. Skin Pharmacology and Physiology 30:
66-75.
Kalsum, N., Sulaeman,
A., Setiawan, B. & Wibawan, I.W.T. 2017. Preliminary studies of the
immunomodulator effect of the propolis Trigona spp. extract in a mouse model. Journal of Agriculture and Veterinary
Science 10(2): 75-80.
Kasote, D.M., Pawar,
M.V., Gundu, S.S., Bhatia, R., Nandre, V.S., Jagtap, S.D., Mahajan, S.G. &
Kulkarni, M.V. 2019. Chemical profiling, antioxidant, and antimicrobial
activities of Indian stingless bees propolis samples. Journal of Apicultural Research 58(4): 617-625.
Khurshid, Z., Naseem, M., Zafar,
M.S., Najeeb, S. & Zohaib, S. 2017. Propolis: A natural biomaterial for
dental and oral healthcare. Autumn 11(4): 265-274.
Kraikongjit, S., Jongjitvimol, T.,
Mianjinda, N., Sirithep, N., Kaewbor, T., Jumroon, N. & Jongjitwimol, J.
2017. Antibacterial effect of plant resin collected from Tetrigona apicalis (Smith, 1857) in Thung Salaeng Luang National
Park, Phitsanulok. Walailak Journal of
Science and Technology 15(8): 599-607.
Kocot, J.,
Kiełczykowska, M., Luchowska-Kocot, D., Kurzepa, J. & Musik, I. 2018.
Antioxidant potential of propolis, bee pollen, and royal jelly: Possible
medical application. Oxidative Medicine
and Cellular Longevity 2018: 7074209.
Kumar, H.R., Reddy,
S.K.M., Shishira, D. & Eshwarappa, G. 2020. Stingless bees in sunflower
pollination. Journal of Entomology and
Zoology Studies 8(1): 299-302.
Kumar, S. &
Alagawadi, K.R. 2013. Anti-obesity effects of galangin, a pancreatic lipase
inhibitor in cafeteria diet fed female rats. Pharmaceutical Biology 51(5): 607-613.
Kustiawan, P.M.,
Lirdprapamongkol, K., Palaga, T., Puthong, S., Phuwapraisirisan, P., Svasti, J.
& Chanchao, C. 2017. Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis,
induced apoptosis in the SW620 human colorectal cancer cell line. BMC Pharmacology and Toxicology 18(32):
1-10.
Lavinas, F.C., Macedo,
E., Sá, G., Amaral, A., Silva, J., Azevedo, M., Vieira, B., Domingos, T.,
Vermelho, A., Carneiro, C. & Rodrigues, I. 2019. Brazilian stingless bee
propolis and geopropolis: Promising sources of biologically active compounds. Brazilian Journal of Pharmacology 29(3):
389-399.
Liberio, S.A., Pereira,
A.L.A., Dutra, R.P., Reis, A.S., Araújo, M.J.A.M., Mattar, N.S., Silva, L.A.,
Ribeiro, M.N.S., Nascimento, F.R.F., Guerra, R.N.M. & Monteiro-Neto, V.
2011. Antimicrobial activity against oral pathogens and immunomodulatory
effects and toxicity of geopropolis produced by the stingless bee Melipona fasciculata Smith. BMC Complementary and Alternative Medicine 11:
108.
López, B., Bataglion,
G., Jara, J.L.P., Filho, E.F.P., Melo, L.S., Cardoso, J.C., Eberlin, M. &
Sawaya, A.C.H.F. 2020. Variation of the phytoestrogen composition of red
propolis throughout the year. Journal of
Apicultural Research 59(4): 406-412.
Mendonça, L., Mendonça,
M., Araújo, Y., Araújo, E., Ramalho, S., Narain, N., Jain, S., Orellana, S., Padilha,
F. & Cardoso, J. 2015. Chemical markers and antifungal activity of red
propolis from Sergipe, Brazil. Food
Science and Technology 35(2): 291-298.
Meyerowitz, S. 2000.
Will you bee mine? Products of the hive. Better
Nutrition (May 2000). pp. 55-58.
Miyata, R., Sahlan, M.,
Ishikawa, Y., Hashimoto, H., Honda, S. & Kumazawa, S. 2019. Propolis
components from stingless bees collected on South Sulawesi, Indonesia, and
their xanthine oxidase inhibitory activity. Journal
of Natural Products 82(2): 205-210.
Mustafa, M.M., Zulkifli,
F.N., Fernandez, I., Mariatulqabtiah, A.R., Sangu, M., Azfa, J.N., Mohamed, M.
& Roslan, N. 2019. Stingless bee honey improves spatial memory in mice,
probably associated with brain-derived neurotrophic factor (BDNF) and inositol 1,4,5-Triphosphate
Receptor Type 1 (Itpr1) genes. Evidence-Based Complementary and Alternative
Medicine 2019: 8258307.
Nazir, H., Shahidan, W.N.S.,
Ibrahim, H.A. & Tuan Ismail, T.N.N. 2018. Chemical constituents of
Malaysian Geniotrigona thoracica propolis. Pertanika Journal of Tropical
Agricultural Science 41(3): 955-962.
Oršolic ́,
N., Jurcevic ́, E.L., Đikic ́, D., Rogic ́, D., Odeh, D.,
Balta, V., Junakovic ́, E.P., Terzic ́, S. & Jutric ́, D.
2019. Effect of propolis on diet-induced hyperlipidemia and atherogenic indices
in mice. Antioxidants 8(6): 156.
Osés, S.M., Marcos, P.,
Azofra, P., de Pablo, A., Fernández-Muíño, M.A. & Sancho, M.T. 2020.
Phenolic profile, antioxidant capacities and enzymatic inhibitory activities of
propolis from different geographical areas: Needs for analytical harmonization. Antioxidants 9(1): 75.
Pazin, W.M., Mônaco,
L.d.M., Eaga Soares, A.E., Miguel, G.F., Berretta, A.A. & Ito, S.A. 2017.
Antioxidant activities of three stingless bee propolis and green propolis
types. Journal of Apicultural Research 56(1):
40-49.
Pino, J.A., Marbot, R.,
Delgado, A., Zumárraga, C. & Sauri, E. 2006. Volatile constituents of
propolis from honey bees and stingless bees from Yucatán. Journal of Essential Oil Research 18(1):
53-56.
PubChem Compound Data
Base. 2021. https://pubchem.ncbi.nlm.nih.gov/ on May, 2021.
Pujirahayu, N.,
Bhattacharjya, D.K., Suzuki, T. & Katayama, T. 2019. α-Glucosidase
inhibitory activity of Cycloartane-type triterpenes isolated from Indonesian
stingless bee propolis and their structure-activity relationship. Pharmaceuticals 12(3): 102.
Ramón-Sierra, J.,
Peraza-López, C., Rodríguez-Borges, R., Yam-Puc, A., Madera-Santana, T. &
Ortiz-Vázquez, E. 2019. Partial characterization of ethanolic extract of Melipona beecheii propolis and in vitro evaluation of its antifungal
activity. Revista Brasileira de
Farmacognosia 29(3): 319-324.
Sakai, T., Ohhata, M.,
Fujii, M., Oda, S., Kusaka, Y., Matsumoto, M., Nakamoto, A., Taki, T.,
Nakamoto, M. & Shuto, E. 2017. Brazilian green propolis promotes weight
loss and reduces fat accumulation in C57BL/6 mice fed a high-fat diet. Biological and Pharmaceutical Bulletin 40:
391-395.
Salatino, A., Pereira,
L.R.L. & Salatino, M.L.F. 2019. The emerging market of propolis of
stingless bees in tropical countries. MOJ
Food Processing and Technology 7(2): 27-29.
Salim, N.H., Omar, E.A.,
Wan Omar, W.A. & Mohamed, R. 2018. Chemical constituents and antioxidant
activity of ethanolic extract of propolis from Malaysian stingless bee Geniotrigona thoracica species. Research Journal of Pharmaceutical,
Biological and Chemical Sciences 9(6): 646-651.
Santos, C.G.D.,
Megiolaro, F.L., Serrao, J.E. & Blochtein, B. 2009. Morphology of the head
salivary and intramandibular glands of the stingless bee Plebeia emerina (Hymenoptera: Meliponini) workers associated with
propolis. Annals of The Entomological
Society of America 102(1): 137-143.
Sari, D.M., Anwar, E.,
Nurjannah & Arifianti, A.E. 2019. Antioxidant and Tyrosinase inhibitor
activities of ethanol extracts of brown seaweed (Turbinaria conoides) as lightening ingredient. Pharmacognosy Journal 11(1): 379-382.
Sawicka, D., Car, H.,
Borawska, M.H. & Nikliński, J. 2012. The anticancer activity of
propolis. Folia Histochem. Cytobiol. 50(1):
25-37.
Sena-Lopes, Â., Bezerra,
F.S.B., das Neves, R.N., de Pinho, R.B., Silva, M.T.O., Savegnago, L.,
Collares, T., Seixas, F., Begnini. K., Henriques, J.A.P., Ely, M.R., Rufatto,
L.C., Moura, S., Barcellos, T., Padilha, F., Dellagostin, O. & Borsuk, S.
2018. Chemical composition, immunostimulatory, cytotoxic and antiparasitic
activities of the essential oil from Brazilian red propolis. PLoS ONE 13(2): e0191797.
Shehu, A., Ismail, S.,
Rohin, M.A.K., Harun, A., Abd Aziz, A. & Haque, M. 2016. Antifungal
properties of Malaysian Tualang honey and stingless bee propolis against Candida albicans and Cryptococcus neoformans. Journal of Applied Pharmaceutical Science 6(2):
44-50.
Silva, M.V., Moura Jr.,
N.G., Motoyama, A.B. & Ferreira, V.M. 2019. A review of the potential
therapeutic and cosmetic use of propolis in topical formulations. Journal of Applied Pharmaceutical Science 10(1): 131-141.
Silveira, C.C.S.M., Luz,
D.A., Silva, C.C.S., Prediger, R.D.S., Martins, M.D., Martins, M.A.T.,
Fontes-Júnior, E.A. & Maia, C.S.F. 2020. Propolis: A useful agent on
psychiatric and neurological disorders? A focus on CAPE and pinocembrin
components. Medical Research Reviews 41(2): 1195-1215.
Simone, M., Evans, J.D. & Spivak, M. 2009. Resin collection
and social immunity in honey bees. Evolution 63(11): 3016-3022.
Speciale, A., Costanzo,
R., Puglisi, S., Musumeci, R., Catania, M.R., Caccamo, F. & Iauk, L. 2006.
Antibacterial activity of propolis and its active principles alone and in
combination with macrolides, beta-lactams and fluoroquinolones against
microorganisms responsible for respiratory infections. Journal of Chemotherapy 18(2): 164-171.
Sulaeman, A., Mahani,
Anwar, F., Damanik, M.R.M., Hardinsyah. & Ploeger, A. 2018. Determination
of Indonesian native stinglee bee propolis as complementary nutraceutical
candidate of anti-tuberculosis drug. International
Journal of Pharmacy and Pharmaceutical Sciences 10(4): 15-21.
Sulaeman, A., Fikri,
A.M., Kalsum, N. & Mahani, M. 2019. Trigona propolis and its potency for health and healing process. In The Role of Functional Food Security in
Global Health, Chapter 25, edited by Singh, R.B., Watson, R.R. &
Takahashi, T. Massachusetts: Academic Press. pp. 425-448.
Torres, A.R., Sandjo, L.P., Friedemann, M.T., Tomazzoli, M.M.,
Maraschin, M.M., Mello, C.F. & Santos, A.R.S. 2018. Chemical
characterization, antioxidant and antimicrobial activity of propolis obtained
from Melipona quadrifasciata
quadrifasciata and Tetragonisca
angustula stingless bees. Brazilian
Journal of Medical and Biological Research 51(6): 1-10.
Vongsak, B.,
Kongkiatpaiboon, S., Jaisamut, S., Machana, S. & Pattarapanich, C. 2015. In vitro alpha glucosidase inhibition
and free-radical scavenging activity of propolis from Thai stingless bees in
Mangosteen orchard. Revista Brasileira de
Farmacognosia 25(5): 445-450.
Wagh, V.D. 2013.
Propolis: A wonder bees product and its pharmacological potentials. Advances in Pharmacological Sciences 2013:
308249.
Wang, S., Wittwer, B.,
Heard, T.A., Goodger, J.Q.D. & Elgar, M.A. 2018. Nonvolatile chemicals
provide a nest defence mechanism for stingless bees Tetragonula carbonaria (Apidae, Meliponini). International Journal of Behavioural Biology 124(9): 633-640.
Zakerkish, M., Jenabi,
M., Zaeemzadeh, N., Hemmati, A.A. & Neisi, N. 2019. The effect of Iranian
propolis on glucose metabolism, lipid profile, insulin resistance, renal
function and inflammatory biomarkers in patients with Type 2 diabetes mellitus:
A randomized double- blind clinical trial. Scientific
Reports 9(7289): 1-11.
*Pengarang
untuk surat-menyurat; email: wanlutfi@upm.edu.my
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