{"id":8864,"date":"2022-04-20T14:17:55","date_gmt":"2022-04-20T06:17:55","guid":{"rendered":"https:\/\/www.ukm.my\/spifper\/researchgroup\/term-copy\/"},"modified":"2025-01-28T10:56:15","modified_gmt":"2025-01-28T02:56:15","slug":"molecularinsights","status":"publish","type":"researchgroup","link":"https:\/\/www.ukm.my\/spifper\/researchgroup\/molecularinsights\/","title":{"rendered":"Molecular Insights to Primary Aldosteronism"},"content":{"rendered":"\t\t
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RESEARCH INTERESTS<\/strong><\/span><\/h4>

The research group of \u201cMolecular Insights to Primary Aldosteronism\u201d consists of a basic scientist and clinical endocrinologists, radiologists, and endocrine surgeons interested in the most common curable form of hypertension, Primary Aldosteronism. Hypertension is a silent killer, affecting 1.3 billion adults worldwide, though less than half are diagnosed and treated. The research of this group has in the past mainly focused on the somatic mutations that can cause unilateral aldosterone-producing adenoma, a surgically curable cause of primary aldosteronism. The interest was especially on the genotype and phenotype relationships as this could help increase the diagnostic rate which is currently estimated to be less than <1%; i.e. 99% of patients with this curable cause of hypertension are not diagnosed and thus inappropriately treated. This is mainly due to the current gold standard of diagnosing this disease is a highly invasive radiological method, adrenal vein sampling, that has a success rate that is dependent on the experience and skill of the radiologist. Thus biomarkers for complete cure of hypertension, both genetics and proteomics, are now being studied in addition to elucidating the mechanism and pathways that regulates zona glomerulosa cell fate, the adrenal zone that physiologically produces aldosterone. The group has a strong international research collaboration ensuring the findings of the research is not only relevant for the Malaysian population, but also replicable in other cohorts. In the future, we hope the research would help to find novel targets to treat hypertension of not only patients with an aldosterone-producing adenoma, but also so called \u201cessential hypertensive\u201d patients, as even non-diseased adrenals are shown to have minute (<2mm) autonomous aldosterone-producing cell clusters (APCC) that cannot be detected by CT-scan.<\/span><\/p>

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MEMBERS OF RESEARCH GROUP<\/strong><\/span><\/h4>
No.<\/strong><\/td>Name<\/strong><\/td>Email<\/strong><\/td>UKM Sarjana<\/strong><\/td>Google Scholar<\/strong><\/td>Scopus<\/strong><\/td><\/tr>
1<\/td>Assoc. Prof. Dr. Elena Aisha Azizan (Group Leader)<\/td>elena.azizan@ukm.edu.my<\/td>UKM<\/a><\/span><\/td>Google Scholar<\/a><\/span><\/td>Scopus<\/a><\/span><\/td><\/tr>
2<\/td>Assoc. Prof. Dr. Nani Harlina Binti Md. Latar<\/td>naniharlinalatar@ukm.edu.my<\/td>UKM<\/a><\/span><\/td>Google Scholar<\/a><\/span><\/td>Scopus<\/a><\/span><\/td><\/tr>
3<\/td>Prof. Dr. Rohaizak Bin Muhammad<\/td>rohaizak@ukm.edu.my<\/td>UKM<\/a><\/span><\/td>Google Scholar<\/a><\/span><\/td>Scopus<\/a><\/span><\/td><\/tr>
4<\/td>Assoc. Prof. Dr. Norasyikin Binti A. Wahab @ A. Rahman<\/td>norasyikinawahab@ukm.edu.my<\/td>UKM<\/a><\/span><\/td>Google Scholar<\/a><\/span><\/td>Scopus<\/a><\/span><\/td><\/tr>
5<\/td>Prof. Dr. Norlela Binti Sukor<\/td>drlela@ppukm.ukm.edu.my<\/td>UKM<\/a><\/span><\/td>Google Scholar<\/a><\/span><\/td>Scopus<\/span><\/a><\/td><\/tr>
6<\/td>Assoc. Prof. Dr. Rozman Bin Zakaria<\/td>rozman@ppukm.ukm.edu.my<\/td>UKM<\/a><\/span><\/td>Google Scholar<\/a><\/span><\/td>Scopus<\/a><\/span><\/td><\/tr>
7<\/td>Assoc Prof. Dr. Nor Azian Abdul Murad<\/td>nor_azian@ppukm.ukm.edu.my<\/td>UKM<\/a><\/span><\/td>Google Scholar<\/a><\/span><\/td>Scopus<\/a><\/span><\/td><\/tr>
8<\/td>Dr. Mun-Kit Choy<\/td>\u00a0<\/td>\u00a0<\/td>Google Scholar<\/td>Scopus<\/td><\/tr>
9<\/td>Prof. Michael Stowasser<\/td>\u00a0<\/td>\u00a0<\/td>Google Scholar<\/td>Scopus<\/td><\/tr>
10<\/td>Prof. Morris Brown<\/td>\u00a0<\/td>\u00a0<\/td>Google Scholar<\/td>Scopus<\/td><\/tr>
11<\/td>Dr. Azraai Bahari Bin Nasruddin<\/td>\u00a0<\/td>\u00a0<\/td>Google Scholar<\/td>Scopus<\/td><\/tr>
12<\/td>Dr. Nor Azmi Kamaruddin<\/td>\u00a0<\/td>\u00a0<\/td>Google Scholar<\/td>Scopus<\/td><\/tr>
13<\/td>Prof. Datuk Dr. A. Rahman A. Jamal<\/td>rahmanj@ppukm.ukm.edu.my<\/td>UKM<\/a><\/span><\/td>Google Scholar<\/span><\/a><\/td>Scopus<\/span><\/a><\/td><\/tr>
14<\/td>Assoc. Prof. Dr. Miroslav Solar<\/td>\u00a0<\/td>\u00a0<\/td>Google Scholar<\/td>Scopus<\/td><\/tr><\/tbody><\/table>

\u00a0<\/h4>

RECENT PUBLICATIONS<\/strong><\/span><\/h4>
1<\/span><\/td>Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause<\/span><\/td>Junhua Zhou, Elena AB Azizan, Claudia P Cabrera, Fabio L Fernandes-Rosa, Sheerazed Boulkroun, Giulia Argentesi, Emily Cottrell, Laurence Amar, Xilin Wu, Sam O\u2019Toole, Emily Goodchild, Alison Marker, Russell Senanayake, Sumedha Garg, Tobias \u00c5kerstr\u00f6m, Samuel Backman, Suzanne Jordan, Satyamaanasa Polubothu, Daniel M Berney, Anna Gluck, Kate E Lines, Rajesh V Thakker, Antoinette Tuthill, Caroline Joyce, Juan Pablo Kaski, Fiona E Karet Frankl, Lou A Metherell, Ada ED Teo, Mark Gurnell, Laila Parvanta, William M Drake, Eva Wozniak, David Klinzing, Jyn Ling Kuan, Zenia Tiang, Celso E Gomez Sanchez, Per Hellman, Roger SY Foo, Charles A Mein, Veronica A Kinsler, Peyman Bj\u00f6rklund, Helen L Storr, Maria-Christina Zennaro, Morris J Brown<\/span><\/td>Nature genetics 53 (9), 1360-1372 (2021)<\/span><\/td><\/tr>
2<\/span><\/td>Functional Characteristic and Significance of Aldosterone-Producing Cell Clusters in Primary Aldosteronism and Age-Related Hypertension<\/span><\/td>Fatin Athirah Pauzi, Elena Aisha Azizan<\/span><\/td>Frontiers in Endocrinology 12, 132 (2021)<\/span><\/td><\/tr>
3<\/span><\/td>Somatic Mutations in Primary Aldosteronism-The Most Common Cause for Secondary Hypertension<\/span><\/td>Siti Khadijah Syed Mohammed Nazri, Elena Azizan<\/span><\/td>Malaysian Journal of Human Genetics 2 (02), 13-24 (2021)<\/span><\/td><\/tr>
4<\/span><\/td>EFFECT OF SILENCING ALDOSTERONE SYNTHASE ON CELL APOPTOSIS IN HAC15 HUMAN ADRENOCORTICAL CELLS<\/span><\/td>Kha Chin Long, Norlela Sukor, Nor Azmi Kamaruddin, Geok Chin Tan, A Rahman A Jamal, Nor Azian Abdul Murad, Morris Jonathan Brown, Elena Aisha Azizan<\/span><\/td>Journal of the ASEAN Federation of Endocrine Societies 36, 11-11 (2021)<\/span><\/td><\/tr>
5<\/span><\/td>RETROSPECTIVE ANALYSIS OF ADRENAL VEIN SAMPLING (AVS) SUCCESS<\/span><\/td>SK Syed Mohammed Nazri, R Zakaria, N Sukor, EA Azizan<\/span><\/td>Journal of the ASEAN Federation of Endocrine Societies 36, 37-37 (2021)<\/span><\/td><\/tr>
6<\/span><\/td>Associations between primary aldosteronism and diabetes, poor bone health, and sleep apnea\u2014what do we know so far?<\/span><\/td>Huai Heng Loh, Norlela Sukor<\/span><\/td>Journal of human hypertension 34 (1), 5-15 (2020)<\/span><\/td><\/tr>
7<\/span><\/td>The effect of vitamin D treatment on clinical and biochemical outcomes of primary aldosteronism<\/span><\/td>Noor Ashikin Ismail, Nor Azmi Kamaruddin, Shamsul Azhar Shah, Norlela Sukor<\/span><\/td>Clinical endocrinology 92 (6), 509-517 (2020)<\/span><\/td><\/tr>
8<\/span><\/td>Association of Single Nucleotide Polymorphisms of CYP11B2, CYP11B1 and CYP17A1 with Primary Aldosteronism in a Multi-Ethnic Malaysian Cohort<\/span><\/td>Afifah Azam, Mohammad Arif Shahar, Siti Liyana Saud Gany, Norlela Sukor, Nor Azmi Kamaruddin, Scott Mackay MacKenzie, Elena Aisha Azizan<\/span><\/td>Journal of the Endocrine Society 4 (Supplement_1), SUN-711 (2020)<\/span><\/td><\/tr>
9<\/span><\/td>A Pilot Genome Wide Association Study (GWAS) on Primary Aldosteronism Patients in a Multi-Ethnic Malaysian Cohort<\/span><\/td>Elena AB Azizan, Mohammad Arif Shahar, Siti Liyana Saud Ghany, A Rahman A Jamal, Nor Azmi Kamaruddin, Norasyikin A Wahab, Ahmad Marzuki Omar, Chin Voon Tong, Azraai Nasruddin, Norlela Sukor, Morris Jonathan Brown, Syahirah Kaja Mohideen<\/span><\/td>Journal of the Endocrine Society 4 (Supplement_1), MON-LB129 (2020)<\/span><\/td><\/tr>
10<\/span><\/td>High Salt Intake May Paradoxically Drive Autonomous Aldosterone Production<\/span><\/td>Elena Aisha Azizan, Kha Chin Long, Norlela Sukor, Ruhaya Salleh, Fatimah Othman, Thamil Arasu Saminathan, Xilin Wu, Junhua Zhou, Feng Jun He, Graham Mac Gregor, Morris Jonathan Brown<\/span><\/td>Journal of the Endocrine Society 4 (Supplement_1), SUN-220 (2020)<\/span><\/td><\/tr><\/tbody><\/table>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t ","protected":false},"featured_media":15247,"template":"","acf":[],"yoast_head":"\nMolecular Insights to Primary Aldosteronism - Secretariat of Research & Innovation Faculty of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ukm.my\/spifper\/researchgroup\/molecularinsights\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecular Insights to Primary Aldosteronism - 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