Sains Malaysiana 47(10)(2018): 2455–2461

http://dx.doi.org/10.17576/jsm-2018-4710-22

 

Association between Pulse Wave Velocity with Other Vascular Markers and Inflammation among Young Adults: An Evidence-Based Review

(Perkaitan antara Halaju Gelombang Nadi dengan Penanda Vaskular Lain dan Inflamasi dalam Kalangan Orang Muda: Satu Penilaian Berasaskan Bukti)

 

NORIZAM SALAMT, AMILIA AMINUDDIN*, AZIZAH UGUSMAN & AINI FARZANA ZULKEFLI

 

Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

Received: 30 March 2018/Accepted: 20 June 2018

 

ABSTRACT

Studies evaluating the association between pulse wave velocity (PWV), a gold standard measurement of aortic stiffness and established markers of cardiovascular disease (CVD), with other established vascular markers or inflammation among young adult is still scarce. A systematic review of the literature was conducted to identify relevant studies on the association between PWV with other vascular markers or inflammation. Relevant articles from Ovid Medline, Science Direct and Scopus databases were explored between 2009 and March 2018. Original articles published in English measuring any correlation between carotid-femoral PWV (PWVcf) with either augmentation index (AIx), carotid intima media thickness (CIMT) or C-reactive protein (CRP) on young adult with age range between 18 and 45 years old were included. The literature search identified 21 potential articles to be reviewed, which meet all the inclusion criteria. Four articles investigated the correlation between PWVcf with CRP, however only two studies gave significant but weak correlations. As for CIMT, a single relevant article was found and the correlation was not significant. In conclusion, lack of association between PWV and other vascular markers and inflammation may suggest that these vascular markers have their own property in assessing vascular status. Thus, these markers should be measured independently for comprehensive assessment of future CVD risk.

 

Keywords: Carotid-femoral pulse wave velocity; inflammation; vascular stiffness; young adults

 

ABSTRAK

Halaju gelombang nadi (PWV) merupakan satu pengukuran piawai kekakuan aorta dan merupakan penanda terkenal penyakit kardiovaskular (CVD). Namun, kajian yang menilai hubungan antara PWV dengan penanda vaskular terkenal yang lain dan inflamasi masih terhad. Sorotan kajian yang sistematik telah dijalankan bagi mengenal pasti kajian yang mengukur hubungan antara PWV dengan penanda vaskular lain atau inflamasi. Pangkalan data Ovid Medline, Science Direct dan Scopus digunakan untuk mencari artikel berkaitan yang diterbitkan dari tahun 2009 sehingga Mac 2018. Hanya artikel asal yang diterbitkan dalam bahasa Inggeris dan mengukur sebarang korelasi antara PWV karotid-femoral (PWVcf) dengan indeks augmentasi (AIx), ketebalan intima media arteri karotid (CIMT) atau protein C-reaktif (CRP) ke atas populasi muda dengan julat umur 18 hingga 45 tahun diterima. Terdapat 21 makalah yang memenuhi semua kriteria kemasukan dan layak untuk dikaji dan dinilai. Empat artikel mengkaji hubungan antara PWVcf dengan CRP, namun hanya dua kajian menunjukkan hubungan yang signifikan namun lemah. Untuk CIMT, satu kajian yang berkaitan telah didapati dan hubungannya dengan PWV adalah tidak signifikan. Kesimpulannya, kekurangan hubungan antara PWV dengan penanda vaskular lain dan inflamasi mungkin menunjukkan setiap penanda vaskular mempunyai sifat tersendiri dalam menilai status vaskular. Sehubungan itu, penanda vaskular tersebut perlu diukur secara berasingan bagi menilai risiko CVD akan datang secara menyeluruh.

 

Kata kunci: Halaju gelombang nadi karotid-femoral; inflamasi; kekakuan vaskular; orang muda

REFERENCES

 

Aminuddin, A., Chellappan, K., Maskon, O., Zakaria, Z., Karim, A.A., Ngah, W.Z. & Nordin, N.A.M. 2014. Augmentation index is a better marker for cardiovascular risk in young Malaysian males. Saudi Medical Journal 35(2): 138-146.

Aminuddin, A., Zakaria, Z., Fuad, A.F., Kamsiah, J., Othman, F., Das, S., Kamisah, Y., Haji S. Qodriyah, H.S., Jubri, Z., Nordin, N.A.M. & Ngah, W.Z. 2013. High C reactive protein associated with increased pulse wave velocity among urban men with metabolic syndrome in Malaysia. Saudi Medical Journal 34(3): 266-275.

Aulie, H.A., Selvaag, A.M., Günther, A., Lilleby, V., Molberg, Ø., Hartmann, A., Holdaas, H. & Flatø, B. 2014. Arterial haemodynamics and coronary artery calcification in adult patients with juvenile idiopathic arthritis. Annals of the Rheumatic Diseases 74(8): 1515-1521.

Blacher, J., Guerin, A.P., Pannier, B., Marchais, S.J., Safar, M.E. & London, G.M. 1999. Impact of aortic stiffness on survival in end-stage renal disease. Circulation 99: 2434-2439.

Cooper, J.N., Tepper, P., Barinas-Mitchell, E., Woodard, G.A. & Sutton-Tyrrell, K. 2012. Serum aldosterone is associated with inflammation and aortic stiffness in normotensive overweight and obese young adults. Clinical and Experimental Hypertension 34(1): 63-70.

Cruickshank, K., Riste, L., Anderson, S.G., Wright, J.S., Dunn, G. & Gosling, R.G. 2002. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: An integrated index of vascular function? Circulation 106: 2085-2090.

Festa, A., D’Agostino, R., Howard, G., Mykkänen, L., Tracy, R.P. & Haffner, S.M. 2000. Chronic subclinical inflammation as part of the insulin resistance syndrome: The Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102: 42-47.

Geraci, G., Mulè, G., Morreale, M., Cusumano, C., Castiglia, A., Gervasi, F., D’Ignoto, F., Mogavero, M., Geraci, C. & Cottone, S. 2016. Association between uric acid and renal function in hypertensive patients: Which role for systemic vascular involvement? Journal of the American Society of Hypertension 10(7): 1-11.

Ghiadoni, L., Penno, G., Giannarelli, C., Plantinga, Y., Bernardini, M., Pucci, L., Miccoli, R., Taddei, S., Salvetti, A. & Del Prato, S. 2008. Metabolic syndrome and vascular alterations in normotensive subjects at risk of diabetes mellitus. Hypertension 51: 440-445.

Greenland, P., Alpert, J.S., Beller, G.A., Benjamin, E.J., Budoff, M.J., Fayad, Z.A., Foster, E., Hlatky, M.A., Hodgson, J.M., Kushner, F.G., Lauer, M.S., Shaw, L.J., Smith, S.C. Jr., Taylor, A.J., Weintraub, W.S., Wenger, N.K. & Jacobs, A.K. 2010. ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 122(25): e584-636.

Hamidon, B.B., Sapiah, S., Nawawi, H. & Raymond, A.A. 2004. The prognostic value of c-reactive protein levels in patients with acute ischaemic stroke. Medical Journal of Malaysia 59(5): 631-637.

Jadhav, U.M. & Kadam, N. 2005. Non-invasive assessment of arterial stiffness by pulse-wave velocity correlates with endothelial dysfunction. Indian Heart Journal 57: 226-232.

Kerkhof, G.F., Breukhoven, P.E., Leunissen, R.W.J., Willemsen R.H. & Hokken-Koelega A.C.S. 2012. Does preterm birth influence cardiovascular risk in early adulthood? The Journal of Pediatrics 161: 390-396.

Kharbanda, R.K., Walton, B., Allen, M., Klein, N., Hingorani, A.D., MacAllister, R.J. & Vallance, P. 2002. Prevention of inflammation-induced endothelial dysfunction: A novel vasculo-protective action of aspirin. Circulation 105: 2600- 2604.

Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I. & Struijker-Boudier, H. 2007. Abridged version of the expert consensus document on arterial stiffness. Artery Research 1: 2-12.

Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I. & Struijker-Boudier, H. 2006. On behalf of the European Network for non-invasive investigation of large arteries. Expert consensus document on arterial stiffness: Methodological issues and clinical applications. European Heart Journal 27: 2588-2605.

Laurent, S., Boutouyrie, P., Asmar, R., Gautier, I., Laloux, B., Guize, L., Ducimetiere, P. & Benetos, A. 2001. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37: 1236-1241.

Liuzzo, G., Biasucci, L.M., Gallimore, J.R., Grillo, R.L., Rebuzzi, A.G., Pepys, M.B. & Maseri, A. 1994. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. New England Journal of Medicine 331: 417-424.

Marchais, S.J., Guerin, A.P., Pannier, B.M., Levy, B.I., Safar, M. & London, G.M. 1993. Wave reflections and cardiac hypertrophy in chronic uremia. Hypertension 22: 876-883.

Mattace-Raso, F.U., van der Cammen, T.J., Hofman, A., van Popele, N.M., Bos, M.L., Schalekamp, M.A., Asmar, R., Reneman, R.S., Hoeks, A.P., Breteler, M.M. & Witteman, J.C. 2006. Arterial stiffness and risk of coronary heart disease and stroke: The Rotterdam Study. Circulation 113: 657-663.

McEniery, C.M., Wallace, S., Mackenzie, I.S., Cockcroft, J.R. & Wilkinson, I.B. 2004. C- reactive protein is associated with arterial stiffness in apparently healthy individuals. Arteriosclerosis, Thrombosis and Vascular Biology 24: 969-974.

Murgo, J.P., Westerhof, N., Giolma, J.P. & Altobelli, S.A. 1980. Aortic input impedance in normal man: Relationship to pressure waveforms. Circulation 62: 105-116.

Nafikudin, M., Nawawi, H., Muid, S., Annuar, R., Yusoff, K. & Khalid, B.A.K. 2003. Measurement of intima-media thickness of common carotid arteries using ultrasound in patients with familial and non-familial hypercholesterolemia and correlation of intima-media thickness to obesity. Medical Journal of Malaysia 58(5): 647-652.

Nilsson, J. 2005. CRP-marker or maker of cardiovascular disease? Arteriosclerosis, Thrombosis and Vascular Biology 25: 1527-1528.

Nuruddin, M.N., Rabeya, Y. & Abdus, S. 2016. Association of plasma C - reactive protein and Coronary Heart Disease (CHD): A study in Bangladesh. International Medical Journal 23(5): 515-517.

Oliver, J.J. & Webb, D.J. 2003. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arteriosclerosis. Thrombosis and Vascular Biology 23: 554-566.

Ozturk, K., Ahmet Uygun, A., Guler, A.K., Demirci, H., Ozdemir, C., Cakir, M., Yusuf Serdar Sakin, Y.S., Turker, T., Sari, S., Demirbas, S., Karslioglu, Y. & Saglam, M. 2015a. Nonalcoholic fatty liver disease is an independent risk factor for atherosclerosis in young adult men. Atherosclerosis 240: 380-386.

Ozturk, K., Guler, A.K., Cakir, M., Ozen, A., Demirci, H., Turker, T., Demirbas, S., Uygun, A., Gulsen, M. & Bagci, S. 2015b. Pulse wave velocity, intima media thickness, and flow-mediated dilatation in patients with normotensive normoglycemic inflammatory bowel disease. Inflammatory Bowel Diseases 21(6): 1314-1320.

Pietri, P., Vyssoulis, G., Vlachopoulos, C., Zervoudaki, A., Gialernios, T., Aznaouridis, K. & Stefanadis, C. 2006. Relationship between low-grade inflammation and arterial stiffness in patients with essential hypertension. Journal of Hypertension 24: 2231-2238.

Pignoli, P., Tremoli, E., Poli, A., Oreste, P. & Paoletti, R. 1986. Intimal plus medial thickness of the arterial wall: A direct measurement with ultrasound imaging. Circulation 74(6): 1399-1406.

Polak, J.F., Pencina, M.J., Pencina, K.M., O’Donnell, C.J., Wolf, P.A. & D’Agostino Sr, R.B. 2011. Carotid-wall intima-media thickness and cardiovascular events. New England Journal of Medicine 365(3): 213-221.

Qawqzeh, Y.K., Reaz, M.B.I. & Ali, M.A.M. 2011. The analysis of PPG contour in the assessment of athersclerosis for erectile dysfunction subjects. WSEAS Transactions on Biology and Biomedicine 4(7): 306-315.

Ramasamy, R., Bucciarelli, L.G., Yan, S.F. & Schmidt, A.M. 2010. Advanced glycation end products, rage, and aging. In Aging and Age-Related Disorders, Oxidative Stress in Applied Basic Research and Clinical Practice. New York: Humana Press.

Ridker, P.M., Rifai, N., Rose, L., Buring, J.E. & Cook, N.R. 2002. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. New England Journal of Medicine 347: 1557-1565.

Ridker, P.M., Rifai, N., Pfeffer, M.A., Sacks, F.M., Moye, L.A., Goldman, S., Flaker, G.C. & Braunwald, E. 1998. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and recurrent events (CARE) investigators. Circulation 98: 839-844.

Ridker, P.M., Cushman, M., Stampfer, M.J., Tracy, R.P. & Hennekens, C.H. 1997. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. New England Journal of Medicine 336: 973-979.

Roberfroid, D., San Miguel, L. & Thiry, N. 2013. Novel serum biomarkers for the prediction of cardiovascular risk: A Technology Assessment (HTA). Brussels: Belgian Health Care Knowledge Center (KCE).

Ross, R. & Glomset, J.A. 1973. Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science 180(4093): 1332-1339.

Safar, M.E. & London, G.M. 2000. Therapeutic studies and arterial stiffness in hypertension: Recommendations of the European Society of Hypertension. The Clinical Committee of Arterial Structure and Function. Working group on vascular structure and function of the European Society of Hypertension. Journal of Hypertension 18: 1527-1535.

Sohani, V., Zahedi, E., Chellappan, K. & Ali, M.A.M. 2012. A review of commercially available non-invasive vascular screening technologies for clinical applications. 2012 IEEE EMBS International Conference in Biomedical Engineering & Sciences. pp. 568-573.

Stoner, L., Young, J.M. & Fryer, S. 2012. Assessments of arterial stiffness and endothelial function using pulse wave analysis. International Journal of Vascular Medicine 2012: 903107.

Venugopal, S.K., Devaraj, S., Yuhanna, I., Shaul, P. & Jialal, I. 2002. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 106: 1439-1441.

Vlachopoulos, C., Aznaouridis, K. & Stefanadis, C. 2010. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: A systematic review and meta-analysis. Journal of American College of Cardiology 55: 1318-1327.

Vyssoulis, G.P., Pietri, P.G., Karpanou, E.A., Vlachopoulos, C.V., Kyvelou, S.M., Spanos, P., Dennis, V.C. & Christodoulos I.S. 2010. Differential impact of metabolic syndrome on arterial stiffness and wave reflections: Focus on distinct definitions. International Journal of Cardiology 138: 119-125.

Wallace, S., McEniery, C.M., Dakham, Z., Pusalkar, P., Maki- Petaja, K., Ashby, M.J., Cockcroft, J.R. & Wilkinson, I.B. 2005. Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness. Arteriosclerosis, Thrombosis and Vascular Biology 25: 372-378.

Willum-Hansen, T., Staessen, J.A., Torp-Pedersen, C., Rasmussen, S., Thijs, L., Ibsen, H. & Jeppesen, J. 2006. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation 113: 664-670.

Wilmer, C.V., Nichols, W. & O’Rourke, M.F. 2005. McDonalds Blood Flow in Arteries - Theoretical, Experimental and Clinical Principles. London: CRC Press.

World Health Organization, 2017. Global Action Plan for the Prevention and Control of Non-Communicable Diseases 2013-2020.

Yu, W.C., Chuang, S.Y., Lin, Y.P. & Chen, C.H. 2008. Brachial-ankle vs carotid-femoral pulse wave velocity as a determinant of cardiovascular structure and function. Journal of Human Hypertension 22: 24-31.

Zahedi, E., Chellappan, K., Ali, M.A.M. & Harwant, S. 2007. Analysis of the effect of ageing on rising edge characteristics of the photoplethysmogram using a modified windkessel model. Cardiovascular Engineering 7(4): 172-181.

Zieman, S.J., Melenovsky, V. & Kass, D. 2005. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arteriosclerosis, Thrombosis and Vascular Biology 25: 932-943.

 

 

*Corresponding author; email: amilia@ppukm.ukm.edu.my

 

 

 

 

 

 

 

 

 

 

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