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Sains Malaysiana 49(11)(2020): 2699-2714
http://dx.doi.org/10.17576/jsm-2020-4911-09
Enantiomeric
Separation of Azole Antifungal Compounds using Chromatographic and
Electrophoretic Techniques: A Mini Review
(Pemisahan Enantiomerik Sebatian Antikulat Azol menggunakan Teknik Kromatografi dan Elektroforetik: Suatu Ulasan Mini)
NURUL RAIHANA BINTI AZHARI1, BOON YIH HUI1, NUR
NADHIRAH MOHAMAD ZAIN1, FAIZ BUKHARI MOHD SUAH2,
SHARIFAH MOHAMAD3,4, NOORFATIMAH YAHAYA1*
& MUGGUNDHA RAOOV3,4*
1Integrative Medicine Cluster, Advanced Medical and Dental
Institute (AMDI), Universiti Sains Malaysia, 13200 Penang, Malaysia
2School of Chemical Sciences, Universiti Sains Malaysia, 11800
Penang, Malaysia
3Department of Chemistry, Faculty of Science, University of
Malaya, 50603 Kuala Lumpur, Malaysia
4University of Malaya Centre for Ionic Liquids, Department of
Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Received: 19 March 2020/Accepted:
12 May 2020
Abstract
The separation of azole antifungal chiral compounds
has gaining much interests since 1980’s as they possess different biological,
pharmaceutical, and pharmacokinetic behaviors at various toxicity levels.
Numerous studies have looked into this subject matter, and therefore, this
review presents an overview on different chiral separation techniques that have
been developed such as liquid chromatography (LC), gas chromatography (GC),
supercritical fluid chromatography (SFC), and capillary electrophoresis (CE).
This comprehensive review also discusses the mechanisms of the developed
analytical methods such as preparation techniques and optimization parameters
towards the enantioseparation performances as well as
their advantages and drawbacks. Lastly, the conclusion and future directions of
the chiral separation, particularly for azole compounds are provided
accordingly.
Keywords: Antifungal compounds; azole; capillary
electrophoresis; chiral separation; chromatographic analysis
Abstrak
Pemisahan sebatian kiral antikulat azol telah menarik perhatian sejak tahun 1980 kerana ia mempunyai sifat biologi, farmaseutik dan farmakokinetik pada tahap ketoksikan yang berbeza. Oleh itu, kajian ini membentangkan gambaran keseluruhan mengenai teknik pemisahan kiral yang berbeza seperti kromatografi cecair (LC), kromatografi gas
(GC), kromatografi cecair supergentingan (SFC) dan elektroforesis rerambut (CE). Kajian komprehensif ini juga membincangkan mekanisme bagi kaedah analisis yang maju seperti teknik penyediaan dan parameter pengoptimuman ke arah persembahan pemisahan enantio serta kelebihan dan kekurangannya. Akhir sekali, kesimpulan dan hala tuju masa depan dalam pemisahan kiral, terutamanya bagi sebatian azol diberikan dengan sewajarnya.
Kata kunci: Analisis kromatografik; azol; pemisahan kiral; rerambut elektroforesis
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*Corresponding author; email: noorfatimah@usm.my
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