Sains Malaysiana 41(4)(2012): 403-409

Absence of Toxicity of Strobilanthes crispa Juice in Acute Oral Toxicity Study in Sprague Dawley Rats

(Ketiadaan Ketoksikan Jus Strobilanthes crispa Bagi Ketoksikan Akut Secara Oral Pada Tikus Sprague Dawley)

N.A. Norfarizan-Hanoon*

School of Health Sciences, Universiti Sains Malaysia

16150 Kubang Kerian, Kelantan, Malaysia

R. Asmah & M.Y. Rokiah

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences

Universiti Putra Malaysia, 43400 Serdang, Selangor D.E., Malaysia

O. Fauziah

Department of Human Anatomy, Faculty of Medicine and Health Sciences

Universiti Putra Malaysia, 43400 Serdang, Selangor D. E., Malaysia

H. Faridah

Malaysian Agricultural Research and Development Institute, Universiti Putra Malaysia

43400 UPM, Serdang, Selangor D.E., Malaysia

Diserahkan: 26 April 2011 / Diterima: 20 Oktober 2011

ABSTRAK

Kajian ini menilai empat dos yang berbeza bagi jus Strobilanthes crispa (700, 2100, 3500 dan 4900 mg kg-1 berat badan) diberikan secara oral kepada tikus betina dan jantan Sprague Dawley ke atas perubahan dalam pelbagai fizikal, perilaku, morfologi dan parameter biokimia. Tikus diubati dengan dos tunggal jus dan diperhatikan selama 14 hari. Tidak ada ketoksikan signifikan yang didapati bagi parameter klinikal dan morfologi organ. Selain itu, tidak ada perubahan signifikan yang diamati pada tahap aspartat aminotransferase, alanin aminotransferase, alkali fosfatase, kreatinin dan albumin. Jus S. crispus didapati selamat pada dos maksimum yang digunakan dalam kajian ini (4900 mg kg-1 berat badan).

Kata kunci: Jus S. crispus; ketoksikan akut; morfologi organ; parameter klinikal

ABSTRACT

This study evaluated four different doses of Strobilanthes crispa juice (700, 2100, 3500 and 4900 mg kg-1 of body weight) administered orally to normal female and male Sprague dawley rats on possible changes in various physical, behaviour, morphology and biochemical parameter. The rats were treated with a single dose of juice and observed for 14 days. No significant toxicity was observed with respect to clinical parameters and organ morphology. In addition, no significant changes were observed in the level of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine and albumin. The S. crispus juice was found to be safe at the maximum dose used in this study (4900 mg kg-1 of body weight).

Keywords: Acute toxicity; clinical parameters; organ morphology; S. crispus juice

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*Pengarang untuk surat-menyurat; email: nhanoon@kk.usm.my