Sains Malaysiana 42(10)(2013): 1431–1438

Ethnobotanical Survey of Medicinal Plants Used for the Treatment of Diabetes in Manisa, Turkey

(Tinjauan Etnobotani bagi Tumbuhan Ubatan yang Digunakan dalam Rawatan Kencing Manis di Manisa, Turki)

C. Durmuşkahya¹* & M. Öztürk^{2 3}

¹Department of Biology, Education Faculty, Celal Bayar University, Demirci, Manisa, Turkey

²Faculty of Forestry, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia

³Botany Dept. Ege Science Faculty, Ege University, 35 Bornova, Izmir, Turkey

Diserahkan: 10 Mac 2013/Diterima: 12 Mei 2013

ABSTRACT

In this study, medicinal plants which are traditionally used for treatment of diabetes mellitus in Manisa and its environs have been investigated. A detailed market survey and ethnobotanical enquiry was performed in the region. In all, 121 medicinal herb dealers were interviewed together with the patients suffering from diabetes. After questionnaire studies, plant specimens were collected from medicinal herb markets known locally as ‘aktars’ or ‘baharatchi’, a total of 27 plant taxa belonging to 15 families were identified to be used for the treatment of diabetes. These taxa mostly belonged to the families Rosaceae (5 taxa), Lamiaceae (3 taxa), Fabaceae (2 taxa) and Asteraceae (2 taxa). The most important anti-diabetic plants are; Zizyphus jujube Mill. (jujube), Origanum onites L. (oregano), Ceracus mahaleb L. (mahaleb) and Trigonella foenum-graecum L. (fenugreek). Attempts are being made to investigate their active compounds responsible for the hypoglycemic activity.

Keywords: Diabetes; ethnobotany; Manisa; medicinal plants; Turkey

ABSTRAK

Dalam kajian ini tumbuhan ubatan yang digunakan secara tradisi bagi rawatan kencing manis di Manisa dan kawasan sekitarnya telah dikaji. Suatu tinjauan pasaran yang terperinci dan penanyaan etnobotani telah dilaksanakan di rantau itu. Sejumlah 121 penjual herba ubatan telah ditemu duga bersama dengan pesakit yang mengidap kencing manis. Selepas kajian soal selidik spesimen tumbuhan  dikutip dari pasar herba ubatan yang dikenali sebagai ‘aktars’ atau ‘baharatchi’, sejumlah 27 takson tumbuhan tergolong kepada 15 famili telah dikenal pasti digunakan bagi rawatan kencing manis. Takson ini kebanyakannya tergolong dalam famili Rosaceae (5 takson), Lamiaceae (3 takson), Fabaceae (2 takson) dan Asteraceae (2 takson). Tumbuhan anti-kencing manis yang terpenting ialah; Zizyphus jujube Mill. (jujube), Origanum onites L. (oregano), Ceracus mahaleb L. (mahaleb) dan Trigonella foenum-graecum L. (fenugreek). Percubaan telah diambil untuk meneliti sebatian aktif yang bertanggungjawab bagi kegiatan hipoglisemia.

Kata kunci: Etnobotani; kencing manis; Manisa; tumbuhan ubatan; Turki

RUJUKAN

Abdel-Barry, J.A., Abdel-Hassan, I.A. & Al-Hakiem, M.H. 1997. Hypoglycemic and antihyperglycemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. Journal of Ethnopharmacology 58: 149-155.

Abo, K.A., Ferd-Jaiyesimi, A.A. & Jaiyesimi, A.E.A. 2008. Ethnobotanical studies of medicinal plants used in the management of diabetes mellitus in South Western Nigeria. Journal of Ethnopharmacology 115: 67-71.

Ahmad, M., Qureshi, R., Arshad, M., Khan, M.A. & Zafar, M. 2009. Traditional herbal remedies used for the treatment of diabetes from district Attock (Pakistan). Pakistan Journal of Botany 41: 2777-2782.

Ali, L., Kalam, A., Khan, A., Hassan, Z., Mosihuzzaman, M., Nahar, N., Nasreen, T., Nure Alam, M. & Rokeya, B. 1995. Characterization of the hypoglycemic effects of Trigonella foenum-graecum seed. Planta Medica 55: 358-360.

Al–Habbori, M. & Raman, A. 1998. Antidiabetic and hypocholesterolemic effects of fenugreek. Phytotherapy Research 12: 233-242.

Amin, R.M., Abdul-Salam, S.A. & Mohammad, S.S. 1988. Effect of Fenugreek and Lupine seeds on the development of experimental diabetes in rats. Planta Medica 54: 286-289.

Aslan, M., Orhan, N., Orhan, D.D. & Ergun, F. 2010. Hypoglycemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes. Journal of Ethnopharmacology 128: 384-389.

Benhaddou-Andaloussi, A., Martineau, L.C., Spoor, D., Vuong, T., Leduc, C., Joly, E., Burt, A., Meddah, B., Settaf, A., Arnason, J.T., Prentki, M. & Haddad, P.S. 2008. Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic β-cells, skeletal muscle cells, and adipocytes. Pharmaceutical Biology 46: 96-104.

Cak?c?, I., Hurmoglu, C., Tunctan, B., Abacioglu, C., Kanzik, I. & Sener, B. 1994. Hypoglycemic effect of Momordica charantia extracts in normoglyemic or cyproheptadine-induced hyperglycemic mice. Journal of Ethnopharmacology 44: 117-121.

Cakiloğlu, U. & Turkoglu, I. 2011. An ethnobotanical survey of medicinal plants in Sivrice (Elaz?ğ-Turkey). Journal of Ethnopharmacology 132: 165-175.

Cakiloglu, U., Khatun, S., Turkoglu, I. & Hayta, S. 2011. Ethnopharmacological survey of medicinal plants in Maden (Elazig-Turkey). Journal of Ethnopharmacology 137: 469- 486.

Ceylan, S., Azal, O. & Taslipinar, A. 2009. Complementary and alternative medicine use among Turkish diabetes patients. Complementary Therapies in Medicine 17: 78-83.

Chaturvedi, P., George, S., Milinganyo, M. & Tripathi, Y.B. 2004. Effect of Momordica charantia on lipid profile and oral glucose tolerance in diabetic rats. Phytotherpea Research 18: 954-956.

Çömlekçioğlu, N. & Karaman, Ş. 2008. The medicinal plants found in the local herbal markets in the city of Kahramanmaraş in Turkey. KSU Journal of Science and Engineering 11: 23-32.

Davis, P.H. 1965-1985. Flora of Turkey and East Aegean Islands. Edinburgh: Edinburgh University Press. Vol:1-10.

Day, C., Cartwright, T., Provost, J. & Bailey, C.J. 1990. Hypoglicemic effects of Momordica charantia extracts. Planta Medica 56: 426-429.

Durmuşkahya, C. 2005. Lower Gediz River Vegetation Ecology, (dissertation). Manisa, Celal Bayar University (Unpublished).

Durmuşkahya, C. 2006. Most Common Trees and Shrubs of Aegean Region (Turkey). Ankara: Forest and Environment Ministry Publishing.

Duman, H. 1985. Flora and vegetation of Manisa Mountain (Spil), (dissertation). Ankara, Gazi University (Unpublished).

Erenmemisoglu, A., Kelestimur, F. & Köker, H. 1995. Hypoglycemic effect of Zizyphus jujuba leaves. Journal Pharm Pharmacology 47: 72-74.

Genet, S., Kale, R.K. & Baquer, N.Z. 1999. Effects of vanadate, insulin and fenugreek (Trigonella foenum graecum) on creatinine kinase levels in tissues of diabetic rat. Indian Journal of Experimental Biology 37: 200-202.

Gomez, M.P.J. & Bhaskar, G. 1998. Antidiabetic effects of fenugreek seed extract (Trigonella foenum-graecum) on Anabas testudineus with special reference to carbohydrate metabolism. Journal of Ecotoxicology & Environmental Monitoring 8: 103-106.

Gupta, R. & Lal, B. 2001. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycemic control and insulin resistance in Type 2 diabetes mellitus: A double blind placebo controlled study. Journal of Association of Physicians of India 49: 1057-1061.

Güner, A., Özhatay, N., Ekim, T. & Başer, K.H.C. 2000. Flora of Turkey and the East Aegean Islands. Edinburgh: Edinburgh University Press.

Israili, Z.H. 2010. Diabetes and Its Treatment with Botanicals in Turkey. Merkez Efendi Symposium Book, Denizli, Turkey.

Israili, Z.H. 2011. Advances in the treatment of type 2 diabetes mellitus. American Journal of Therapeutics 18: 117-152.

Inanç, N., Çiçek, B. & Sahin, H. 2007. Use of herbs by the patients with diabetes in Kayseri, Turkey. Pakistan Journal of Nutrition 6: 310-312.

Jayasooriya, A.P., Sakono, M., Yukizaki, C., Kawano, M., Yamamoto, K. & Fukuda N. 2000. Effects of Momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets. Journal of Ethnopharmacology 72: 331-336.

Kaushik, G., Satya, S., Khandewal, K.R. & Naik, S.N. 2010. Commonly consumed Indian plant food materials in the management of diabetes mellitus, diabetes & metabolic syndrome. Clinical Research & Reviews 4: 21-40.

Khatir, A.M.M., Ding, X.L. & Fang, T. 1999. Hypoglycaemic effect of fenugreek gum on normal and alloxan diabetic rats. Journal of Wuxi University of Light Industry: 18: 16-20.

Khosla, P., Gupta, D.D. & Nagpal, R.K. 1995. Effect of Trigonella foenum-graecum (Fenugreek) on blood glucose in normal and diabetic rats. Indian Journal of Physiological Pharmacology 39: 173-174.

Küçükgüçlü, Ö., K?z?lc?, S., Mert, H., Uğur, Ö., Besen, D.B. & Ünsal, E. 2010. Complementary and alternative medicine use among people with diabetes in Turkey. Western Journal of Nursing Research 22: 20-26.

Latiff, A., Ismail, G., Omar, M., Said, M.I. & Kadri, A. 1980. A multivariate approach to the study of medicinal plants in Malaysia. Journal Singapore National Academy of Science 13: 101113.

Leatherdale, B.A., Panesar, R.K., Singh, G., Atkins, T.W., Bailey, C.J. & Bignell, A.H. 1981. Improvement in glucose tolerance due to Momordica charantia (karela). British Medical Journal (Clin. Res. Ed.) 282: 1823-1824.

Li, W., Zheng, H.C., Bukuru, J. & De Kimpe, N. 2004. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of Ethnopharmacology 92: 1-24.

Miura, T., Itoh, C., Iwamoto, N., Kato, M., Kawai, M., Park, S.R. & Suzuki, I. 2001. Hypoglycemic activity of the fruit of the Momordica charantiain type 2 diabetic mice. Journal of Nutrition, Sciences and Vitaminology 47: 340-344.

Onal, S., Timur, S., Okutucu, B. & Zihnioğlu, F. 2005. Inhibition of alpha-glucosidase by aqueous extracts of some potent antidiabetic medicinal herbs. Preparative Biochemistry and Biotechnology 35: 29-36.

Özbek, H., Ceylan, E., Kara, M., Özgökçe, F. & Koyuncu, M. 2004. Hypoglycemic effect of Rheum ribes roots in alloxan induced diabetic and normal mice. Scand. J. Lab. Anim. Sci. 31(2): 113-115.

Öztürk, Y., Aykut, M., Kelestimur, F., Günay, O., Çetinkaya, F. & Ceyhan, O. 2000. Prevalance of diabetes mellitus and affected factors in the district of Kayseri. Turk. J. Med. Sci. 30: 181-185.

Polat, R. & Sat?l, F. 2012. An ethnobotanical survey of medicinal plants in Edremit Gulf (Bal?kesir- Turkey). Journal of Ethnopharmacology 139: 626-641.

Raman, A. & Lau, C. 1996. Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine 2: 349-362.

Ribes, G., Savaire, Y., Baccou, J.C., Valette, G., Chenon, D. & Trimble, D.R. 1984. Effects of fenugreek seeds on endocrine pancreatic secretions in dogs. Annals of Nutrition Metabolism 28: 37-43.

Satman, I., Yilmaz, T. & Sengul, A. 2002. Population-based study of diabetes and risk characteristics in Turkey: Results of the Turkish Diabetes Epidemiology Study (TURDEP). Diabetes Care 25: 1551-1556.

Shani, J., Goldschmied, A., Joseph, B., Zhronson, A. & Sulman, F.G. 1974. Hypoglycemic effect of Trigonella foenum graecum and Lupinus termis seeds and their major alkaloids in alloxan diabetic and normal rats. Achievements of International Pharmacodynamical Therapy 214: 27-37.

Shirdel, Z., Madani, H. & Mirbadalzadeh, R. 2009. Investigation into the hypoglycemic effect of hydroalcoholic extract of Ziziphus Jujuba Leaves on blood glucose and lipids in Alloxan-Induced diabetes in rats. Iranian Journal of Diabetes and Lipid Disorders 1: 13-19.

Smirin, P., Taler, D., Abitbol, G., Brutman-Barazani, T., Kerem, Z., Sampson, S.R. & Rosenzwig, T. 2010. Sarcopoterium spinosum extract as an antidiabetic agent: In vitro and in vivo study. Journal of Ethnopharmacology 129: 10-17.

Stark, A. & Madar, Z. 1993. The effect of an ethanol extract derived from fenugreek (Trigonella foenum-graecum) on bile acid absorption and cholesterol levels in rats. British Journal of Nutrition 69: 277-287.

Trojan-Rodrigues, M., Alves, T.L.S., Soares, G.L.G. & Ritter, R.M. 2012. Plants used as antidiabetics in popular medicine in Rio Grande do Sul, southern Brazil. Journal of Ethnopharmacology 139: 155-163.

Tuzlac?, E. & Tolon, E. 2000. Turkish folk medicinal plants, Part III: Şile (İstanbul-Turkey), Fitoterapia 71: 673-685.

Tuzlac?, E. & Aymaz, P.E. 2001. Turkish folk medicinal plants. Part IV: Gönen (Bal?kesir-Turkey). Fitoterapia: 72: 323-343.

Vats, V., Grover, J.K. & Rathi, S.S. 2001. Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenum-graecum Linn., Ocimum sanctum Linn. and Pterocarpus marsupium Linn. in normal and alloxanized diabetic rats. Journal of Ethnopharmacology 79: 95-100.

*Pengarang untuk surat-menyurat; email: cdkahya@gmail.com