Sains Malaysiana 47(11)(2018): 2811–2820

http://dx.doi.org/10.17576/jsm-2018-4711-24

 

Olive and Its Phenolic Compound as the Promising Neuroprotective Agent

(Sebatian Fenolik di dalam Buah Zaitun Berpotensi sebagai Agen Perlindungan Saraf)

 

KHIDHIR KAMIL1, JAYA KUMAR1, MUHAMMAD DAIN YAZID2  & RUSZYMAH BINTI HAJI IDRUS1*

 

1Department of Physiology, Faculty of Medicine, UKM Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras , Kuala Lumpur, Federal Territory, Malaysia

 

2Tissue Engineering Centre, Faculty of Medicine, UKM Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

Diserahkan: 30 Mac 2018/Diterima: 30 Julai 2018

 

ABSTRACT

 

Recent progress in alternative medicine has highlighted the benefits of olive as an integral part of therapeutic diet to promote healthy living. Among the thirty different phenolic compounds of olive known to date; oleocanthal, oleuropein, tyrosol and hydroxytyrosol are being increasingly investigated for their potential in prevention and healing of several major forms of neurological dysfunctions and disorders. A considerable amount of literature suggests the neuroprotective effects of olive and its phenolic compounds are owing to their roles as anti-oxidant, anti-inflammatory and anti-apoptotic agents. At preclinical level, olive attenuated cognitive dysfunctions and the functional outcomes in spinal cord injury, delayed the progression of amyloid beta pathology, improved motor and mitochondrial dysfunctions in Parkinson’s disease, reversed diabetic-related neurological complications and also ameliorated cerebral pathologies in stroke. In this paper, we aim to review the neuroprotective role of olive and its phenolic derivatives in the following diseases or deficits of the nervous system that include cognitive dysfunction, neurodegenerative diseases, stroke, peripheral neuropathy and spinal cord injury.

 

Keywords: Neuroprotection; neurodegeneration; neuropathy; nerve; olive; olea europaea

 

ABSTRAK

 

Perkembangan terkini dalam perubatan alternatif telah membuktikan khasiat buah zaitun sebagai bahan penting dalam diet yang menggalakkan gaya hidup sihat. Antara tiga puluh sebatian fenolik yang terdapat di dalam buah zaitun; oleocantal, oleuropein, tirosol dan hidroksitirosol telah dikaji dengan kerap akan potensinya dalam mencegah dan merawat beberapa penyakit berkaitan saraf. Beberapa kajian telah mengesyorkan keupayaannya dalam memberi perlindungan adalah disebabkan oleh fungsinya sebagai anti-oksidan, anti-radang dan anti-apoptosis. Kesan zaitun ke atas perlindungan sistem saraf masih belum diterokai sepenuhnya diperingkat ujian klinikal setakat ini. Manakala di peringkat pra-klinikal pula, buah zaitun mampu memperbaiki fungsi kognitif otak, mengurangkan komplikasi akibat daripada kecederaan saraf tunjang, melambatkan kesan patologi oleh protein amiloid beta, memperbaiki fungsi motor dan mitokondria dalam penyakit Parkinson’s, merawat komplikasi penyakit diabetes dan mengurangkan kerosakan tisu kepada otak semasa strok. Dalam kertas ini, kesan perlindungan buah zaitun dalam kategori penyakit seperti berikut: kerosakan fungsi kognitif, penyakit neurodegeneratif, strok, peripheral neuropati dan kecederaan saraf tunjang akan didalami.

 

Kata kunci: Buah zaitun; neurodegeneratif; neuropati; olea europaea; perlindungan saraf; saraf

 

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*Pengarang untuk surat-menyurat; email: ruszyidrus@gmail.com

 

 

 

 

 

 

 

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