Sains Malaysiana 49(2)(2020): 399-404

http://dx.doi.org/10.17576/jsm-2020-4902-18

 

Clinical Significance of Blood Supply of the Fornix of Brain: A Cadaveric Study

(Keertian Klinikal Pembekuan Darah Forniks Otak: Suatu Kajian Kadaverik)

 

PATCHARAPORN SRISAIKAEW1,2, TANAT VANIYAPONG3, SRIJIT DAS4 & PASUK MAHHAKRANUKRAUH1,5,6*

 

1PhD Degree Program in Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 52000, Thailand

 

2Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 52000, Thailand

 

3Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, 52000, Thailand

 

4Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur, Federal Territory, Malaysia

 

5Forensic Osteology Research Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

 

6Research Cluster in Osteology Research and Training Center (ORTC), Chiang Mai University, Chiang Mai, 50200, Thailand

 

Diserahkan: 21 September 2019/Diterima: 5 November 2019

 

Abstract

Transient ischemic attack (TIA) of the fornix causes a spectrum of memory deficits, which increases the contributions of vascular disease to dementia which is known as early-onset dementia.  As the fornix, the white matter bundle, serves as the major efferent pathway connecting the hippocampus with other human limbic structures, a variety of lesions that damage the fornix could lead to significant memory impairment. Therefore, the blood supply of fornix is a concern. This study aims to study the arterial supply of fornix. Thirty fresh human cadaveric heads were used.  They were preserved by the mixture of fixation solution for fornix anatomical dissection and injected with coloured latex solution for visualization of cerebral vasculature through 6 critical steps of approaches.  The result showed that the fimbriae of fornix were mainly supplied by the branches of posterior cerebral artery (PCA) and two cases were found to have the anastomoses of those branches with the choroidal artery (ChA). The proposed technique confirmed the ability of coloration of human cerebral vasculature by using colored latex solution which penetrated into cerebral small vessels leading to a precise understanding of the arterial supply of fornix in human brain which is essential for neurosurgeon, neurosurgical training and researchers.

 

Keywords: Arteries; brain; fixation; fornix; latex injection

 

Abstrak

Serangan iskemik sementara (TIA) di fornix menyebabkan pelbagai spektrum defisit memori yang secara langsung meningkatkan sumbangan penyakit vaskular kepada demensia yang juga dikenali sebagai demensia permulaan-awal. Oleh kerana fornix terdiri daripada kumpulan jirim putih yang berfungsi sebagai laluan eferen utama yang menghubungkan hipokampus dengan struktur limbik manusia yang lain, kecederaan yang merosakkan fornix boleh mengakibatkan kerosotan memori yang ketara. Oleh itu, bekalan darah fornix menjadi kebimbangan. Tujuan penyelidikan ini adalah untuk mengkaji bekalan saluran darah arteri fornix. Tiga puluh kepala daripada kadaver yang segar telah digunakan. Setiap kepala diawetkan dengan campuran cecair fiksasi untuk pembedahan anatomi fornix dan disuntik dengan larutan lateks berwarna untuk memvisualisasikan vaskular serebrum melalui pendekatan 6 langkah yang kritikal. Hasil kajian ini menunjukkan bahawa fimbria fornix kebanyakannya dibekalkan oleh rangkaian arteri serebral posterior (PCA) dan terdapat dua kes dengan penyambungan cabang arteri ini bersama dengan arteri koroid (ChA) dijumpai. Teknik yang dikemukakan ini mengesahkan keupayaan pewarnaan vaskular serebrum manusia dengan menggunakan larutan lateks berwarna yang boleh menembusi salur darah kecil serebral dan membawa kepada pemahaman yang terperinci terhadap bekalan saluran darah arteri fornix di dalam otak manusia yang terbukti penting untuk pakar bedah saraf, latihan bedah saraf dan untuk para penyelidik.

 

Kata kunci: Arteri; fiksasi; fornix; otak; suntikan lateks

 

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