Sains Malaysiana 45(1)(2016): 71–77

Liposomes as Amphiphilic Carriers: Encapsulation and Stability Aspects

(Liposom sebagai Pengangkut Amfifili: Aspek Pengkapsulan dan Kestabilan)



1Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur



2Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, Malaysia


3Department of Pharmacy, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, Malaysia


4Department of Geology, Faculty of Science, University of Malaya 50603 Kuala Lumpur



5Water Research Unit, Faculty of Science and Natural Resources, University Malaysia Sabah,

88400 Kota Kinabalu, Sabah, Malaysia



Received: 21 July 2014/Accepted: 2 December 2014



The aimed of the present study was to evaluate the liposomal formulation regarding its hydrophobicity. The evaluation studies were done based on the amphiphilic nature of the phospholipid liposomes. This paper highlights the importance of such type of lipid based carriers by encapsulation hydrophobic and hydrophilic drug models. Crystal violet and Nile red were used to represent hydrophilic and hydrophobic moieties before moving to pharmaceutical implications. The formulated liposomes were compared for their hydrophobicity using percent encapsulation efficiencies. The purpose of this formulation was to mimic the red blood cells. The average particle size of 120±25.1 and zeta potential of -10.2±1.4 were in good agreement with reported characteristics of the red blood cells. Per cent encapsulation efficiency for crystal violet was more obvious with a value of 68.1 as compared to 36.5% for Nile red. The prepared liposomes were quite stable for a period of one month. Our findings reflect the fate of our system more suitable for hydrophilic drugs under the given set of formulation parameters.


Keywords: Crystal violet; drug hydrophobicity; Nile red; percent encapsulations; phospholipid carriers



Matlamat kajian ini adalah untuk menilai penggubalan liposomal mengenai kehidrofobiannya. Kajian penilaian telah dijalankan berdasarkan sifat amfili daripada liposom fosfolipid. Kertas kerja ini membincangkan kepentingan apa-apa jenis penerbangan yang berpangkalan lipid oleh hidrofobi pengkapsulan dan model dadah hidrofili. Kristal ungu dan Nil merah telah digunakan untuk mewakili moieti hidrofili dan hidrofobi sebelum berpindah ke implikasi farmaseutik. Formulasi liposom dibandingkan untuk kehidrofobiannya menggunakan suatu kecekapan pengkapsulan peratus. Tujuan pembentukan ini adalah untuk meniru sel darah merah. Purata saiz zarah 120±25.1 dan potensi zeta daripada -10.2±1.4 adalah sama dengan ciri yang dilaporkan untuk sel darah merah. Peratus kecekapan pengkapsulan untuk kristal ungu adalah lebih jelas dengan nilai sebanyak 68.1 berbanding 36.5% bagi Nil merah. Liposom yang disediakan agak stabil untuk tempoh satu bulan. Penemuan kami menunjukkan sistem kami lebih sesuai untuk dadah hidrofili dengan parameter formulasi yang diberikan.


Kata kunci: Dadah kehidrofobiannya; kristal ungu; Nil merah; pembawa fosfolipid; peratus pengkapsulan


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