Sains Malaysiana 46(10)(2017): 1877–1886

http://dx.doi.org/10.17576/jsm-2017-4610-26

 

Observation of Tumour-induced Reorganization in Structural and Functional Architecture of the Brain in Three Pre-surgical Patients with Left Frontal-temporal Brain Tumour: A Combination of MEG, DTI and Neuropsychological Assessment

(Pemerhatian Tumor Menyebabkan Perubahan pada Struktur dan Fungsi Otak dalam Tiga Pesakit Pra-pembedahan yang menghidap Tumor Otak pada Bahagian Frontal-Temporal: Kombinasi MEG, DTI dan Penilaian Neuropsikologi)

 

HANANI ABDUL MANAN1*, ZAMZURI IDRIS2,3, MOHAMMED FARUQUE REZA3, WAN NOR AZLEN WAN MOHAMAD3 & JAFRI MALIN ABDULLAH2

 

1Department of Radiology, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

2Center for Neuroscience Service and Research, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan Darul Naim, Malaysia

 

3Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan Darul Naim, Malaysia

 

 

Received: 3 January 2017/Accepted: 29 September 2017

 

ABSTRACT

Visual function is mainly located within the bilateral hemisphere of the occipital lobes of the brain. However, our functional magnetoencephalography (MEG) result has demonstrated the reorganization of brain activity in the occipital area in patients with left-sided brain tumour. The results showed that brain laterality changes from bilateral to unilateral activation of the occipital area. Right occipital area (contralateral areas to the tumour), shows increase intensity of activation. Diffusion tensor imaging (DTI) with fibre tracking was performed to further investigate this brain laterality modification and the findings confirmed there is an alteration in the left hemisphere fibre optic tracts. This functional modification and changes of the brain laterality and optic tracts in the brain is suspected to be the result of tumour growth induced changes. The present observation will be discussed in term of the mechanism of tumour induced reorganization and changes with the corroborating evidence from MEG, DTI and neuropsychological assessment.

 

Keywords: Diffusion tensor imaging; magnetoencephalography; neuroplasticity; visual evoked field and functional shifted

ABSTRAK

Fungsi visual terletak pada kedua-dua belah bahagian hemisfera lobus osipital. Walau bagaimanapun, hasil kajian kefungsian dengan menggunakan magnetoensefalografi (MEG) menunjukkan berlakunya pengubahsuaian pada pengaktifan otak bagi pesakit yang menghidap tumor pada sebelah kiri otak. Keputusan menunjukkan pengaktifan unilateral pada pesakit tersebut iaitu pada sebelah kontralateral pada bahagian tumor. Keputusan kajian ini turut disokong oleh keputusan daripada pengimejan tensor resapan (DTI). Keputusan daripada pengimejan DTI turut menunjukkan terdapatnya perubahan pada optik fiber pada sebelah kiri hemisfera. Perubahan kefungsian dan perubahan pada optik fiber ini dicadangkan disebabkan oleh tumor. Keputusan pemerhatian ini akan dibincangkan daripada segi makanisme keplastikan neuro dengan menghubungkan bukti daripada pengimejan MEG, DTI dan ujian psikologi.

 

Kata kunci: Keplastikan neuro; magnetoensefalografi; pengimejan tensor resapan; rangsangan medan penglihatan dan kefungsian teranjak

REFERENCES

Bashir, S., Mizrahi, I., Weaver, K., Fregni, F. & Pascual-Leone, A. 2010. Assessment and modulation of neural plasticity in rehabilitation with transcranial magnetic stimulation. PM&R 2(12 Suppl 2): S253-S268.

Bavelier, D. & Neville, H.J. 2002. Cross-modal plasticity: Where and how? Nature Reviews Neuroscience 3(6): 443-452.

Begley, S. & Check, E. 2000. Rewiring your gray matter. The brain: You can teach an old brain new tricks. Neuroplasticity promises to give a whole new meaning to ‘changing your mind’. Newsweek 134(26): 63-65.

Behrman, A.L., Bowden, M.G. & Nair, P.M. 2006. Neuroplasticity after spinal cord injury and training: An emerging paradigm shift in rehabilitation and walking recovery. Physical Therapy 86(10): 1406-1425.

Boadas-Vaello, P., Castany, S., Homs, J., Alvarez-Perez, B., Deulofeu, M. & Verdu, E. 2016. Neuroplasticity of ascending and descending pathways after somatosensory system injury: Reviewing knowledge to identify neuropathic pain therapeutic targets. Spinal Cord 54(5): 330-340.

Boissonneau, S. & Duffau, H. 2017. Identifying clinical risk in low grade gliomas and appropriate treatment strategies, with special emphasis on the role of surgery. Expert Review of Anticancer Therapy 17(8): 703-716.

Britton, J.W., Cascino, G.D., Sharbrough, F.W. & Kelly, P.J. 1994. Low-grade glial neoplasms and intractable partial epilepsy: Efficacy of surgical treatment. Epilepsia 35(6): 1130-1135.

Chen, H., Epstein, J. & Stern, E. 2010. Neural plasticity after acquired brain injury: Evidence from functional neuroimaging. PM&R 2(12 Suppl 2): S306-S312.

Dellani, P.R., Glaser, M., Wille, P.R., Vucurevic, G., Stadie, A., Bauermann, T., Tropine, A., Perneczky, A., von Wangenheim, A. & Stoeter, P. 2007. White matter fiber tracking computation based on diffusion tensor imaging for clinical applications. Journal of Digital Imaging 20(1): 88-97.

Di, J., Cohen, L.S., Corbo, C.P., Phillips, G.R., El Idrissi, A. & Alonso, A.D. 2016. Abnormal tau induces cognitive impairment through two different mechanisms: Synaptic dysfunction and neuronal loss. Scientific Reports 6: 20833.

Duffau, H. 2014. Diffuse low-grade gliomas and neuroplasticity. Diagnostic and Interventional Imaging 95(10): 945-55.

Duffau, H. 2006. Lessons from brain mapping in surgery for low-grade gliomas: Study of cerebral connectivity and plasticity. Medical Imaging and Augmented Reality 4091: 25-35.

Duffau, H. 2005. Lessons from brain mapping in surgery for low-grade glioma: Insights into associations between tumour and brain plasticity. The Lancet Neurology 4(8): 476-486.

Giese, A., Bjerkvig, R., Berens, M.E. & Westphal, M. 2003. Cost of migration: Invasion of malignant gliomas and implications for treatment. Journal of Clinical Oncology 21(8): 1624-1636.

Hu, W., Shen, F., Chen, G., Shen, G., Liu, W. & Zhou, J. 2009. Possible involvement of brain tumour stem cells in the emergence of a fast-growing malignant meningioma after surgical resection and radiotherapy of high-grade astrocytoma: Case report and preliminary laboratory investigation. Journal of International Medical Research 37(1): 240-246.

Johnson, P., Jaggon, J.R., Campbell, J., Bruce, C., Ferron, D., James, K., Crandon, I. & Eldemire-Shearer, D. 2015. Profile of a malignant brain tumour in Jamaica: An eight-year review, 2005 to 2012. West Indian Medical Journal 64(4): 372-375.

Krieg, S.M., Sollmann, N., Hauck, T., Ille, S., Foerschler, A., Meyer, B. & Ringel, F. 2013. Functional language shift to the right hemisphere in patients with language-eloquent brain tumors. PLoS One 8(9): e75403.

Kunesch, E., Classen, J., Bettag, M., Kahn, T., Ulrich, F., Bock, W.J., Freund, H.J. & Seitz, R.J. 2003. Representational cortical plasticity associated with brain tumours: Evidence from laser-induced interstitial thermotherapy. Acta Neurologica Scandinavica 108(3): 201-208.

Maeshima, S., Shigeno, K., Dohi, N., Kajiwara, T. & Komai, N. 1992. A study of right unilateral spatial neglect in left hemispheric lesions: The difference between right-handed and non-right-handed post-stroke patients. Acta Neurologica Scandinavica 85(6): 418-424.

Manan, H.A., Franz, E.A., Yusoff, A.N. & Mukari, S.Z. 2015. The effects of aging on the brain activation pattern during a speech perception task: An fMRI study. Aging Clinical and Experimental Research 27(1): 27-36.

Mandonnet, E., Delattre, J.Y., Tanguy, M.L., Swanson, K.R., Carpentier, A.F., Duffau, H., Cornu, P., van Effenterre, R., Alvord, E.C. & Capelle, L. 2003. Continuous growth of mean tumor diameter in a subset of grade II gliomas. Annals of Neurology 53(4): 524-528.

Mizuno, K., Tsuji, T., Rossetti, Y., Pisella, L., Ohde, H. & Liu, M. 2013. Early visual processing is affected by clinical subtype in patients with unilateral spatial neglect: A magnetoencephalography study. Frontiers in Human Neuroscience 7: 432.

Mori, S. & van Zijl, P.C. 2002. Fiber tracking: Principles and strategies - a technical review. NMR in Biomedicine 15(7- 8): 468-480.

Nakamura, M., Yanagisawa, T., Okamura, Y., Fukuma, R., Hirata, M., Araki, T., Kamitani, Y. & Yorifuji, S. 2015. Categorical discrimination of human body parts by magnetoencephalography. Frontiers in Human Neuroscience 9: 609.

Oberlin, L.E., Verstynen, T.D., Burzynska, A.Z., Voss, M.W., Prakash, R.S., Chaddock-Heyman, L., Wong, C., Fanning, J., Awick, E., Gothe, N., Phillips, S.M., Mailey, E., Ehlers, D., Olson, E., Wojcicki, T., McAuley, E., Kramer, A.F. & Erickson, K.I. 2015. White matter microstructure mediates the relationship between cardiorespiratory fitness and spatial working memory in older adults. NeuroImage 131: 91-101.

Park, Y., Yu, E.S., Ha, B., Park, H.J., Kim, J.H. & Kim, J.Y. 2017. Neurocognitive and psychological functioning of children with an intracranial germ cell tumor. Cancer Research and Treatment 49(4): 960-969.

Pascual-Leone, A., Amedi, A., Fregni, F. & Merabet, L.B. 2005. The plastic human brain cortex. Annual Review of Neuroscience 28: 377-401.

Reichert, J.L., Chocholous, M., Leiss, U., Pletschko, T., Kasprian, G., Furtner, J., Kollndorfer, K., Krajnik, J., Slavc, I., Prayer, D., Czech, T., Schopf, V. & Dorfer, C. 2017. Neuronal correlates of cognitive function in patients with childhood cerebellar tumor lesions. PLoS One 12(7): e0180200.

Rosler, J., Niraula, B., Strack, V., Zdunczyk, A., Schilt, S., Savolainen, P., Lioumis, P., Makela, J., Vajkoczy, P.Frey, D. & Picht, T. 2014. Language mapping in healthy volunteers and brain tumor patients with a novel navigated TMS system: Evidence of tumor-induced plasticity. Clinical Neurophysiology 125(3): 526-536.

Roux, F.E., Boulanouar, K., Ibarrola, D., Tremoulet, M., Chollet, F. & Berry, I. 2000. Functional MRI and intraoperative brain mapping to evaluate brain plasticity in patients with brain tumours and hemiparesis. Journal of Neurology, Neurosurgery, and Psychiatry 69(4): 453-463.

Sabbah, N., Sanda, N., Authie, C.N., Mohand-Said, S., Sahel, J.A., Habas, C., Amedi, A. & Safran, A.B. 2017. Reorganization of early visual cortex functional connectivity following selective peripheral and central visual loss. Scientific Reports 7: 43223.

Seki, Y., Kandori, A., Ogata, K., Miyashita, T., Kumagai, Y., Ohnuma, M., Konaka, K. & Naritomi, H. 2010. Note: Unshielded bilateral magnetoencephalography system using two-dimensional gradiometers. Review of Scientific Instruments 81(9): 096103.

Shahani, U., Lang, G., Mansfield, D.C., Halliday, D.M., Weir, A.I., Maas, P. & Donaldson, G.B. 2001. Magnetoencephalography and stereopsis: Rhythmic cortical activity in humans recorded over the parieto-occipital cortex. Neuroscience Letters 315(3): 154-158.

Walker, D.G. & Kaye, A.H. 2003. Low grade glial neoplasms. Journal of Clinical Neuroscience 10(1): 1-13.

Wang, W., Steward, C.E. & Desmond, P.M. 2009. Diffusion tensor imaging in glioblastoma multiforme and brain metastases: The role of p, q, L, and fractional anisotropy. American Journal of Neuroradiology 30(1): 203-208.

Wilkinson, D., Ko, P., Wiriadjaja, A., Kilduff, P., McGlinchey, R. & Milberg, W. 2009. Unilateral damage to the right cerebral hemisphere disrupts the apprehension of whole faces and their component parts. Neuropsychologia 47(7): 1701-1711.

 

 

*Corresponding author; email: hanani@ukm.edu.my

 

 

 

 

 

 

previous