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Sains Malaysiana 51(8)(2022):
http://doi.org/10.17576/jsm-2022-5108-07
Benefits of Coriandrum
sativum L. Seed Extract in Maintaining Immunocompetent Cell Homeostasis
(Kebaikan Ekstrak Biji Coriandrum sativum L. dalam Mengekalkan Homeostasis Sel Imunokompeten)
SRI RAHAYU1,*, MUHAIMIN RIFA’I1,
DAHLIATUL QOSIMAH2, SRI WIDYARTI1, NOVIANA DWI LESTARI1,
YOGA DWI JATMIKO1, WIRA EKA PUTRA3,4 & HIDEO TSUBOI5
1Biology
Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran Malang 65145, East Java, Indonesia
2Laboratory of
Microbiology and Immunology, Faculty of Veterinary Medicine, Brawijaya University, Jl.
Veteran Malang 65145, East Java, Indonesia
3Department
of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang 65145, Indonesia
4Department
of Biotechnology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang 65145, Indonesia
5Department
of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya 466-8550, Japan
Received: 26
October 2020/Accepted: 16 February 2022
Abstract
Diabetes
mellitus (DM) is a metabolic disease followed by an increase in blood glucose
and impaired metabolism of proteins, lipids and carbohydrates. In general,
these conditions are caused by impaired insulin secretion and/or defects of
insulin receptors. As yet, there is no effective drug capable of treating DM.
Manifestations of DM worsen when accompanied by severe inflammation. Therefore,
the avoiding strategy and management of inflammation in DM are the primary
courses of action in preventing further damage. In this study, we had evidence
that Coriandrum sativum L. extract (CSE) could be used as an alternative to relieve symptoms
in DM mice model. Previously, CSE has been shown to be able to inhibit the
synthesis of the pro-inflammatory molecule interleukin (IL)-6 by both B220 and
CD11b cells. Here, we showed that CSE prevents over-activation of CD4 and CD8 T
lymphocytes. The predominance of T cells expressing CD62L on both CD4 and CD8 T
cells after administration of CSE indicated that there were obstacles to
activation. CSE also suppressed excessive CD25 expression, causing CD25
expression in CD4 T cells to return to normal levels. Thus, this study showed
the therapeutic activity of CSE in DM mice model by suppressing the
pro-inflammatory cytokines, modulate the activation of naïve T cells, and
maintain the population of CD4+CD25+ cells.
Keywords: Coriandrum sativum L.;
diabetes mellitus; interleukin-6; pro-inflammatory Abstrak
Diabetes
mellitus (DM) adalah penyakit metabolik yang diikuti oleh peningkatan glukosa darah dan gangguan metabolisme protein, lipid dan karbohidrat. Secara umumnya, keadaan ini disebabkan oleh rembesan insulin yang terjejas dan/atau kecacatan reseptor insulin. Setakat ini, tiada dadah berkesan yang mampu merawat DM. Manifestasi DM bertambah teruk apabila disertai dengan keradangan yang teruk. Oleh itu, strategi mengelakkan dan pengurusan keradangan dalam DM adalah tindakan utama dalam mencegah kerosakan selanjutnya. Dalam kajian ini,
kami mempunyai bukti bahawa ekstrak Coriandrum
sativum L. (CSE) boleh digunakan sebagai alternatif untuk melegakan gejala dalam model tikus DM. Sebelum ini, CSE telah ditunjukkan dapat merencat sintesis molekul pro-radang interleukin
(IL)-6 oleh kedua-dua sel B220 dan CD11b. Di sini, kami menunjukkan bahawa CSE menghalang pengaktifan berlebihan limfosit CD4 dan CD8 T. Penguasaan sel T yang mengekspreskan CD62L pada kedua-dua sel T
CD4 dan CD8 selepas perlakuan CSE menunjukkan bahawa terdapat halangan untuk pengaktifan. CSE juga menindas ekspresi CD25 yang berlebihan menyebabkan ekspresi CD25 dalam sel T CD4 kembali ke tahap normal. Oleh itu, kajian ini menunjukkan aktiviti terapeutik CSE dalam model tikus DM dengan menekan sitokin pro-radang, memodulasi pengaktifan sel T naif dan mengekalkan populasi sel CD4+CD25+.
Kata kunci: Coriandrum sativum L.; diabetes mellitus; interleukin-6; pro-radang
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*Corresponding author; email: srahayu@ub.ac.id
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