Sains Malaysiana 47(11)(2018): 2741–2755

http://dx.doi.org/10.17576/jsm-2018-4711-17

 

Ficus carica and Bone Health: A Systematic Review

(Ficus carica dan Kesihatan Tulang: Suatu Kajian Sistematik)

 RUSZYMAH BT HJ IDRUS*1, NUR QISYA AFIFAH VERONICA SAINIK1, AYU SURAYA ANSARI1, MOHAMED S. ZULFARINA3, RABIATUL ADAWIYAH RAZALI1, ABID NORDIN1, Aminuddin bin Saim2 & Isa Naina-Mohamed3  

1Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre,

Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

2Ear, Nose & Throat Consultant Clinic, Ampang Puteri Specialist Hospital, 68000, Ampang, Selangor Darul Ehsan, Malaysia

 3Pharmacoepidemiology Unit, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

Diserahkan: 1 Februari 2018/Diterima: 20 Jun 2018

 

ABSTRACT

Ficus carica, a native plant to the Middle East and Western Asia, is of high value in folk medicine. The therapeutic potential of Ficus carica has led to the extensive studies in recent years, focusing on evaluating and validating its pharmacological effect. The present systematic review summarizes the effectiveness of Ficus carica on promoting bone health focusing on osteoporosis and rheumatoid arthritis via mineral contents and RANKL pathway. The search was done with Medline via Ebscohost, Scopus and Google Scholar databases to obtain relevant articles published between 1946 and December 2016. The main inclusion criteria were research articles published in English that reported effect of Ficus carica on bone health. The literature search returned 716 potentially relevant articles, whereby 5 met the inclusion criteria. This systematic review concludes Ficus carica plays an important role in the promotion of bone health and can be a potential pharmaceutical product in the future.

 

Keywords: Bone; Ficus carica; osteoporosis; RANKL pathway; rheumatoid arthritis

 

ABSTRAK

Ficus carica ialah tumbuhan asli di Timur Tengah dan Asia Barat mempunyai kepentingan dalam perubatan tradisi. Potensi terapeutik Ficus carica telah membawa kepada kajian mendalam tertumpu kepada pengesahan kesan farmakologinya. Kajian sistematik ini mendalami keberkesanan Ficus carica dalam membantu kesihatan tulang yang memfokus kepada penyakit osteoporosis dan ‘reumatoid artritis’ melalui kandungan mineralnya dan laluan RANKL. Carian makalah telah dibuat menggunakan pangkalan data Medline melalui Ebscohost, Scopus dan Google Scholar untuk mendapatkan makalah berkaitan yang diterbitkan antara 1946 dan December 2016. Kriteria serta utama untuk pemilihan makalah adalah penerbitan dalam Bahasa Inggeris yang melaporkan kesan Ficus carica kepada kesihatan tulang. Carian makalah menghasilkan 716 makalah yang berpotensi dengan 5 makalah menepati kriteria rangkuman. Kesimpulan kajian sistematik ini membuktikan bahawa Ficus carica memainkan peranan penting dalam membantu meningkatkan kesihatan tulang dan boleh dijadikan sebagai produk farmaseutik yang berpotensi pada masa hadapan.

 

Kata kunci: Ficus carica; laluan RANKL; osteoporosis; reumatoid artritis; tulang

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 *Pengarang untuk surat-menyurat; email: ruszyidrus@gmail.com

 

 

 

 

 

 

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