CRISPR Simulator
Choose your level
Each level unlocks more advanced CRISPR science. Complete levels in order.
DNA Fundamentals
Learn how DNA is structured and how to identify mutations in a gene sequence.
CRISPR Surgery
Perform a complete CRISPR-Cas9 editing procedure step by step — PAM site, guide RNA, off-target, cut.
Design Your Own CRISPR
Enter your own DNA target, design a guide RNA, run off-target analysis, and predict your edit outcome.
How to play: Drag a nucleotide from the palette onto an empty slot on Strand 2. A pairs with T; G pairs with C. Wrong drops turn red. Drag a filled slot back to the palette area to remove it.
How to play: Compare the reference sequence (top) with the patient sequence (bottom). Click every base in the patient sequence that differs from the reference. Wrong clicks shake red. Use "Reveal all" if stuck.
How to play: Complete all 4 steps of the CRISPR-Cas9 protocol. Each step has a hint. Use the Back button to revisit any previous step.