Sains Malaysiana 50(3)(2021): 791-801


Honey Ameliorate Negative Effects in Neurodegenerative Diseases: An Evidence-Based Review

(Madu Memperbaiki Kesan Negatif dalam Penyakit Neurodegeneratif: Suatu Ulasan Berdasarkan Bukti)




1Department of Physiology, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia


2Centre for Tissue Engineering & Regenerative Medicine, Clinical Block, UKM Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia


3Ear, Nose and Throat Consultant Clinic, Ampang Puteri Specialist Hospital, Taman Dato Ahmad Razali, 68000 Ampang, Selangor Darul Ehsan, Malaysia


Diserahkan: 12 Julai 2020/Diterima: 25 Ogos 2020



Neurodegenerative diseases are cluster of disorders arising from neuronal cell death in the central nervous system. Its prevalence increases with increasing age. Therapeutic options for neurodegenerative disease include protection against oxidative damage, attenuation of neuroinflammation, maintenance of essential neurotransmitters, and protection against environmental factors that induce neurotoxicity. Honey with its antioxidative, anti-inflammatory, and cytoprotective effects is a potential candidate for therapy in neurodegenerative diseases. The present evidence-based review summarizes the effects of honey on neurodegenerative diseases in non-human subjects. Three electronic databases, namely PubMed, Ovid Medline and Scopus were searched for records published from inception of database to May 2020 to identify reports on the association of honey and neurodegenerative diseases. Based on the preset eligibility criteria, 8 qualified articles were selected and discussed in this review. Honey from different geological origin around the globe was used by different researcher among the studies included. Honey confers protection against oxidative stress induced by hypoxia and metabolic syndrome, aluminium toxicity, and neuroinflammation. Honey also demonstrated potential ability to inhibit neurotransmitters degrading enzymes and restore memory impairment. This review showed a sparse body of evidence on the potential of honey as neurodegenerative disease therapy.


Keywords: Antioxidant; honey; memory loss; neurodegenerative disease; regeneration



Penyakit neurodegeneratif adalah satu kumpulan penyakit yang muncul daripada kematian sel saraf di dalam sistem saraf pusat. Prevalens penyakit neurodegeneratif meningkat dengan peningkatan usia. Antara strategi rawatan penyakit ini adalah perlindungan daripada kerosakan oksidatif, pengawalan keradangan saraf, pemeliharaan neuropemancar penting dan perlindungan daripada faktor persekitaran yang boleh mengakibatkan ketoksikan saraf. Madu dengan kesan antioksida, anti-keradangan dan perlindungan sito merupakan calon yang berpotensi untuk perawatan penyakit neurodegeneratif dalam subjek bukan manusia. Tiga pengkalan data, PubMed, Ovid Medline dan Scopus digunakan untuk mengenal pasti rekod yang diterbitkan daripada permulaan pangkalan data sehingga Mei 2020 yang melaporkan kaitan madu dan penyakit neurodegeneratif. Berdasarkan kriteria yang ditetapkan, 8 artikel yang bersesuaian dipilih dan dibincangkan dalam kajian ini. Madu daripada punca geografi yang pelbagai di serata dunia telah digunakan oleh pengkaji yang berbeza disertakan dalam kajian ini. Madu menunjukkan perlindungan ke atas penyakit neurodegeneratif melalui perlindungan daripada tekanan oksida yang dihasilkan oleh kekurangan oksigen dan sindrom metabolik, perlindungan daripada ketoksikan aluminium dan perlindungan daripada keradangan saraf. Madu turut menunjukkan kebolehan untuk mencatutkan enzim penguraian neuropemancar dan memulihkan kehilangan memori. Kajian ini menunjukkan jurang pengetahuan dalam penggunaan madu untuk rawatan penyakit neurogeneratif.


Kata kunci: Antioksida; kehilangan memori; madu; penjanaan semula; penyakit neurodegeneratif



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