BIOSENSOR & LAB-ON-CHIP LAB

  • Biosensor & Lab-on-Chip Laboratory focuses on the design, fabrication, and application of miniaturized analytical devices using expertise in Microelectromechanical Systems (MEMS) and Nanoelectronics (NEMS).

Head of Laboratory

Prof. Dato'. Dr. Burhanuddin Yeop Majlis

burhan@ukm.edu.my

PIC Laboratory

Anezah Marsan

anezahmarsan@ukm.edu.my

PIC Laboratory

Mohd Faizal Aziz

faizal_imen@ukm.edu.my

EQUIPMENT / FACILITIES

PLASMA TREATMENT MACHINE
  • A Plasma Treatment Machine is a specialized laboratory or industrial device used to modify the surfaces of materials by exposing them to a low-temperature, highly reactive ionized gas (plasma). 

    • How It Works / Principle: The machine operates by generating a plasma—the fourth state of matter—inside a vacuum chamber. A vacuum pump removes air and non-process gases from the chamber to reach a low-pressure environment. A specific process gas (e.g., Ar, O2, CF4, or H2) is introduced into the chamber. Radio frequency (RF) power is applied to electrodes, which energizes the gas molecules. The energy strips electrons from the gas atoms, creating a plasma composed of ions, free radicals, electrons, and neutral species.

    • Key Features & Advantages

      • Precision and Uniformity: Provides highly uniform and repeatable surface modification across the entire substrate area

      • Controllable Surface Chemistry: Allows for precise control over the type of chemical groups introduced onto the surface (e.g., hydroxyl, amino, or carboxyl groups)

      • Ultra-Cleaning Capability: Capable of ultra-fine cleaning to remove invisible organic residues down to the nanoscale, which is crucial for bonding and coating 

      • Non-Thermal Damage: Operates at low temperatures (non-thermal plasma), allowing the treatment of heat-sensitive materials like polymers and biological substrates without damage

    • Applications: Biomedical devices, microelectronics/semiconductor, microfluidics and Lab-on-a-Chip, Adhesion Improvement and Adhesion Improvement

  • A Four-Point Probe System is a tool used to accurately measure the electrical resistivity, sheet resistance, and in advanced configurations, the capacitance-voltage (C-V) characteristics of semiconductor wafers, thin films, and various materials
  • How It Works / Principle

    Current (I) is sourced between the two outer probes, while the resulting voltage (V) drop is measured across the two inner probes. Since I and V are measured independently of the high-resistance contacts, the resulting resistivity (ρ) or sheet resistance (Rs) calculation is highly accurate using geometric correction factors. The principle is based on Ohm’s Law (R=V/I).

    In C-V configurations, the system measures the capacitance (C) of a device as a function of the applied voltage (V). This principle allows for the calculation of critical parameters like doping concentration, flat-band voltage, and oxide thickness

  • Key Features & Advantages

    • High Accuracy: Provides significantly more accurate resistance measurements than two-point probes by eliminating contact resistance errors.

    • Non-Destructive/Minimal Damage:The probes make only a minimal physical contact with the sample surface.

    • Versatility: Capable of measuring a wide range of materials, including conductive thin films, semiconductors, and even novel 2D materials.

    • Integrated Analysis: includes integrated software to automatically apply geometric correction factors and calculate bulk resistivity or sheet resistance.
    • Combined Capability (I-V & C-V): Advanced systems can perform both current-voltage (transport) and capacitance-voltage (device physics) measurements using the same platform.
  • Applications Thin Film Characterization, Material Research, Device Physics, Quality Control

  • An Impedance Analyzer is an electronic test instrument used to measure the complex electrical impedance (Z), capacitance (C), inductance (L), and other electrical parameters of a device, material, or circuit over a specified range of frequencies
  • How It Works / Principle

    The analyzer applies a small, alternating current (AC) excitation signal (voltage or current, typically sinusoidal) to the Device Under Test (DUT) across a range of frequencies. It then measures the resulting AC current and voltage across the DUT.

  • Key Features & Advantages

    • Wide Frequency Range: Capable of sweeping measurements from low Hertz (Hz) to high GigaHertz (GHz), enabling characterization from slow electrochemical processes to high-speed RF circuits.

    • High Measurement Accuracy: Provides precise and stable measurements of minute changes in electrical properties, often required for material characterization.
    • Versatile Parameter Measurement: Simultaneously measures multiple parameters, including , Dissipation Factor (), and Quality Factor ().
    • Modeling and Analysis: Often includes software for plotting data (e.g., Nyquist plots and Bode plots) and fitting the data to equivalent circuit models.
  • Applications

    Materials Science, Electrochemistry/Batteries, Sensor Development, Component Testing, Biological Systems

Laboratory oven is designed for precise temperature control and uniform heating, primarily used for routine drying, sterilization, aging, conditioning, and curing of various materials and samples.

  • How It Works / Principle:

    The oven heats the chamber air to a set point and maintains it with high stability and homogeneity. Electrical heating elements (typically positioned around the chamber walls) generate heat. A highly precise PID controller (Proportional-Integral-Derivative) constantly monitors the internal temperature via sensors and adjusts the power supplied to the heating elements, ensuring the temperature remains stable with minimal overshoot.

  • Key Features & Advantages
    • Temperature Uniformity: Excellent temperature distribution and stability, crucial for repeatable results, often exceeding industry standards.
    • User-Friendly Control: Equipped with a high-resolution display and intuitive controller for easy programming, temperature monitoring, and timer functions.
    • Safety Features: Includes multiple over-temperature protection systems (e.g., electronic and mechanical monitors) to prevent thermal runaway and protect samples.
    • High-Quality Build: Features a seamless, deep-drawn stainless steel inner chamber, which is easy to clean, highly durable, and corrosion-resistant.
    •  
  • Applications

    Material drying, sterilization, curing and aging, conditioning and thermal testing and general laboratory heating

  • A Memmert Sterilizer is a dedicated laboratory oven designed for hot air sterilization of non-liquid medical, dental, and laboratory instruments at temperatures up to 300oC, utilizing natural convection for gentle and quiet operation.
  • How It Works / Principle

    The process is based on dry heat sterilization, where high temperatures (>160oC) are maintained for a specific duration to destroy all microbial life, including spores. Electrical heating elements heat the air within the chamber. A precise PID controller and sensors maintain the set sterilization temperature (e.g., 180oC ) with exceptional accuracy and stability. Heat transfer relies solely on the natural buoyancy and density differences of the heated air. This creates a gentle and silent circulation pattern, ensuring the chamber atmosphere is uniform without disturbing light or sensitive materials. The machine executes a programmed cycle that includes a heating phase, a holding time (the actual sterilization period), and a cooling phase, ensuring compliance with relevant sterilization standards.

  • Key Features & Advantages
    • Compliance: Meets stringent national and international sterilization standards (DIN 12880 etc.)

    • Gentle Treatment: Natural convection provides a non-turbulent, gentle environment, ideal for materials (like powders, delicate glassware, or packaged goods) that should not be disturbed by forced air circulation.

    • Advanced Safety: Includes multi-level over-temperature protection (both electronic and mechanical) to guarantee the safety of the samples and the laboratory environment.
    • High-Grade Materials: Features a durable, corrosion-resistant, and easy-to-clean stainless steel inner chamber.
  • Applications Laboratory Sterilization, Medical/Dental Practices, Pharmaceutical Industry, Drying and Heat Treatment