Our research team investigates the fundamental biological and pharmacological principles underpinning drug functions. We aims to translate our research findings for clinical and therapeutic benefit.
CURRENT ACTIVE PROJECTS:
A/ Prof Endang Kumulosasi
Molecular Mechanisms of phytoestrogens and Annexin A1 in inducing apoptosis and cell cycle arrest through modulation of caspase cascade, p53, p21 and cyclins proteins expression in Human Leukemic Cell Lines.
Dr Norsyafinaz Yaakob
Investigating the effects of 5-HT3 antagonists and gingerol-rich Zingiber officinale extract on chronic nicotine addiction & toxicity in rodents.
Dr Chua Eng Wee
Understanding the genetic basis of the Neuroprotective effect of caffeine on the developing brain using an in vitro CRISPR gene-editing system.
The genetic basis of caffeine sensitivity is not well understood. We are using CRISPR to create a cell model that would allow us to gauge the effect of a DNA variant in the ADORA1 gene – the therapeutic target of caffeine – on caffeine response.
Optimising the amplification of long DNA fragments: the role of PCR additives and emulsion PCR.
Dr Mohd Kaisan Mahadi
Transcutaneous vagus nerve stimulation: Investigation on macrophage polarisation through cholinergic anti-inflammatory pathway in rats with induced myocardial infarction.
The proposed pathway of autonomic neuromodulation from transcutaneous vagus nerve stimulation. Image acquired from Murray et al 2016.
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