Infection & Immunology
INFECTIOUS DISEASE
RESEARCH INTERESTS
Research in the field of bacteriology, parasitology, mycology and virology that is conducted at the Faculty of Medicine UKM goes under the collective name of “Infectious Diseases”. Research in our group is carried out in several scientific areas which generates a diversified environment where cross integration between different fields has the potential to generate novel and groundbreaking concepts.
MEMBERS OF RESEARCH GROUP
| 1 | Assoc. Prof. Dr. Alfizah Hanafiah (Group leader) | alfizah@ppukm.ukm.edu.my | Helicobacter pylori infection, molecular epidemiology of infectious diseases and antibiotic resistance, gastric cancer | https://www.scopus.com/authid/detail.uri?authorId=6508004846 | https://scholar.google.com/citations?user=&user=9X84tuEAAAAJ | https://ukmsarjana.ukm.my/main/lihat_profil/SzAwOTY4MA== | Sukri A, Lopes BS, Hanafiah A. 2021. The emergence of multidrug-resistant Helicobacter pylori in Southeast Asia: a systematic review on the trends and intervention strategies using antimicrobial peptides. Antibiotics 10:1061. https://doi.org/10.3390/antibiotics10091061 |
| 2 | Assoc. Prof. Dr. Asrul Abdul Wahab | saw@ppukm.ukm.edu.my | https://scholar.google.com/citations?user=tlvoJjUAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxNTQxNQ== | Rajalingham Sakthiswary, Syahrul Sazliyana Shaharir, Asrul Abdul Wahab. (2022). Frequency And Clinical Significance Of Elevated Igg4 In Rheumatoid Arthritis: A Systematic Review. – Biomedicines. 1-12. | ||
| 3 | Assoc. Prof. Dr. Neoh Hui-Min | hui-min@ppukm.ukm.edu.my | genome surveillance and molecular detection of antimicrobioc-resistant pathogens | https://www.scopus.com/authid/detail.uri?authorId=8708371500 | https://scholar.google.com/citations?hl=en&user=5O8wo4wAAAAJ | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxNjg0Mg== | Ismail MAH, Kamarudin N, Abdul Samat MN, Raja Abdul Rahman RMF, Saimun S, Tan TL, Neoh HM. Methicillin-Resistant Staphylococcus aureus (MRSA) Clonal Replacement in a Malaysian Teaching Hospital: Findings from an Eight-Year Interval Molecular Surveillance. Antibiotics (Basel). 2021 Mar 19;10(3):320. doi: 10.3390/antibiotics10030320. PMID: 33808728; PMCID: PMC8003425. |
| 4 | Assoc. Prof. Dr. Ramliza Ramli | ramliza@ppukm.ukm.edu.my | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxNDkyMA== | Azlina Ibrahim, Isa Naina Mohamed, Lau Chee Lan, Ramliza Ramli, Najma Kori, Petrick Periyasamy. (2021). An Observational Prospective Study On The Appropriateness Of Ceftriaxone Use In Medical Wards Of Ppukm. – International Journal Of Infectious Diseases (Ijid). 104. | |||
| 5 | Assoc. Prof. Datin. Dr. Noor Zetti Zainol Rashid | zetti@ppukm.ukm.edu.my | Virology & infectious diseases (viral hepatitis, HIV, respiratory viruses), molecular diagnostics, immunisation | https://www.scopus.com/authid/detail.uri?authorId=35622590200 | https://scholar.google.com/citations?user=2H5AqrAAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMDU4OA== | Rashid ZZ, Lee PC, Ali UK, Samat, A, Tang SF. Multiplex real-time PCR detection of respiratory viruses in lower respiratory tract infections in children. Sains Malaysiana 2018, 47(11), pp. 2821–2829 |
| 6 | Assoc. Prof. Dr. Tzar Mohd Nizam Khaithir | tzar@ppukm.ukm.edu.my | Medical Mycology, antimicrobial susceptibility | https://www.scopus.com/authid/detail.uri?authorId=35176638800 | https://scholar.google.com.my/citations?user=t6bfjsAAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMTUzNA== | Mohd Nizam Tzar, Wan Husna Barakah Meor Jamaludin, Asrul Abdul Wahab, Chuan Hun Ding. (2022). Exophiala Dermatitidis, “The Real Black Fungus” Fungemia In A Patient With Covid-19. – Idcases. 1-3. |
| 7 | Assoc. Prof. Dr. Ding Chuan Hun | dingch@ppukm.ukm.edu.my | https://www.scopus.com/authid/detail.uri?authorId=57171426800 | https://scholar.google.com/citations?user=cKNk6vsAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxNDUyOQ== | Ting Siau Mei Valerie, Chuan Hun Ding, Asrul Abdul Wahab. (2021). Brain Abscess Caused By Salmonella Enteritidis Following Craniotomy For Meningioma: A Case Report And Literature Review. – Malaysia Journal Of Pathology. 333-336. | |
| 8 | Assoc. Prof. Dr. Mohd Rohaizat Hassan | rohaizat@ppukm.ukm.edu.my | https://scholar.google.com/citations?user=2CNb_QEAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMzU5OQ== | Rahmat Dapari, Mohd Hafizuddin Mahfot, Ahmad Iqmer Nashriq Mohd Nazan, Mohd Rohaizat Hassan, Nazri Che Dom, Syed Sharizman Syed Abdul Rahim. (2022). Acceptance Towards Decriminalization Of Medical Marijuana Among Adults In Selangor, Malaysia. – Plos One. 1-17. | ||
| 9 | Assoc. Prof. Dr. Nazarudin Safian | nazarudin@ppukm.ukm.edu.my | https://scholar.google.co.uk/citations?user=kP18GZoAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxNzkxOQ== | Mohd Rizal A. Manaf, Azmawati Md Nawi, Noorlaili Md Tauhid, Hanita Othman, Md Rizam A. Rahman, Hanizah Md Yusoff, Nazaruddin Safian, Pei Yuen Ng, Zahara A. Manaf, Nor Bayah Abd Kadir, Kevina Yanasegaran, Siti Munirah Abd Basir, Sowmya R., Kurubaran G.. (2021). Prevalence Of Metabolic Syndrome And Its Associated Risk Factors Among Staffs In A Malaysian Public University. – Scientific Reports. 1-11. | ||
| 10 | Assoc. Prof. Dr. Petrick @ Ramesh Periyasamy | petrick@ppukm.ukm.edu.my | Infectious Diseases | https://scholar.google.com/citations?user=FgcY2HkAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxNDM1Ng== | Petrick Periyasamy, Ng Boon Hau, Umi Kalsom Satariah Ali, Zetti Zainol Rashid, Najma Kori. (2021). Aerosolized Sars-Cov-2 Transmission Risk: Surgical Or N95 Masks?. – Infection Control & Hospital Epidemiology. 1150-1152. | |
| 11 | Assoc. Prof. Mohamed Faisal Abdul Hamid | arabinose@hotmail.com | https://scholar.google.com/citations?user=ko_DWB4AAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAyMDUzMw== | Hafiz Aizat Shuhaimi, Boon Hau Ng, Yu-Lin Andrea Ban, Nik Nuratiqah Nik Abeed, Mohamed Faisal Abdul Hamid. (2021). Intrapleural Alteplase And Dnase For Complex Tuberculous Pleural Effusion. – Respirology. 236-237. | ||
| 12 | Assoc. Prof. Andrea Ban Yu-Lin | andreaban@gmail.com | https://scholar.google.com/citations?user=eXcA4boAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxNTIzMg== | Mas Fazlin Mohamad Jailaini, Mohamed Faisal Abdul Hamid, Andrea Ban Yu-Lin, Boon Hau Ng, Nik Nuratiqah Nik Abeed. (2021). The Successful Of Intrapleural Alteplase And Pulmozyme In Treating Rhodococcus Empyema In An Immunocompromised Patient. – Respirology. 196-197. | ||
| 13 | Datin Dr. Anita Sulong | dranita@ppukm.ukm.edu.my | https://scholar.google.com.my/citations?user=SExhUREAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMzQzOA== | Zalina Ismail, Siti Fatimah Abdullah, Asrul Abdul Wahab, Tuan Suhaila Tuan Soh, Anita Sulong. (2021). Modified Carbapenem Inactivation Method (Mcim) For Detection Of Carbapenemase Production In Klebsiella Spp. – International Journal Of Infectious Diseases. 27. | ||
| 14 | Dr. Syamsa Rizal Abdullah | syamsarizal.abdullah@ppukm.ukm.edu.my | Forensic Entomology, Medical Entomology | https://www.scopus.com/authid/detail.uri?authorId=37058471100 | https://scholar.google.com/citations?user=metnhNYAAAAJ&hl=en&oi=ao | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMzQ3OQ== | Syamsa, R.A, Omar, B., Ahmad, F.M.S., Hidayatulfathi, O., Shahrom, A.W. (2017). Comparative fly species composition on indoor and outdoor forensic cases in Malaysia. Journal of Forensic & Legal Medicine. 45:41-46 |
| 15 | Dr. ‘Azlin Mohd Yasin | azlinmy@ukm.edu.my | Tissue parasite, Soil-Transmitted Helminth, Ectoparasite | https://www.scopus.com/authid/detail.uri?authorId=8625546000 | https://scholar.google.com/citations?user=oK-9QrAAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMzMwMA== | Tengku Shahrul Anuar, Norhayati Moktar, Mohamed Kamel Abdul Ghani, Emelia Osman, Azlin Mohd Yasin, Anisah Nordin, Siti Nor Azreen, Fatmah Md Salleh, Nuraffini Ghazali, Mekadina Bernadus, Hesham M…. (2012). Giardiasis Among Different Tribes Of Orang Asli In Malaysia: Highlighting The Presence Of Other Family Members Infected With Giardia Intestinalis As A Main Risk Factor. – International Journal For Parasitology. 42(9):871-880. |
| 16 | Dr. Anisah Nordin | anisah.nordin@ukm.edu.my | Medical Parasitology, Free-living Amoeba | https://www.scopus.com/authid/detail.uri?authorId=14218884200 | https://scholar.google.com/citations?user=FecqwGYAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAwOTM2OQ== | Sook-Luan Ng, Anisah Nordin, Norzana Abd Ghafar, Yusof Suboh, Noraina Ab Rahim And Kien Hui Chua. (2017). Acanthamoeba-Mediated Cytopathic Effect Correlates With Mbp And Ahlbp Mrna Expression. – Parasites And Vectors. 1-14. |
| 17 | Dr. Emelia Osman | emelia.osman@ukm.edu.my | Molecular Diagnosis of Parasitic Infection, Serum Proteomic | https://www.scopus.com/authid/detail.uri?authorId=37061755400 | https://scholar.google.com/citations?user=4UB-fFEAAAAJ&hl=en&oi=ao | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMzk0OQ== | Zainudin NS, Nasarudin SNS, Periyasamy P, Moktar M, Noordin R, Osman E. 2016. Diagnosis of disseminated microsporidiosis: Detection of circulating E.nterocytozoon bieneusi in blood of HIV/AIDS patients. Tropical Biomedicine. 33(4): 761-770 |
| 18 | Dr. Aishah Hani Azil | aishah.azil@ppukm.ukm.edu.my | Medical Entomology, Biology and Control Parasite and Disease Vector | https://www.scopus.com/authid/detail.uri?authorId=36656977300 | https://scholar.google.com/citations?user=j2DVFQEAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMzkwMg== | Mohd Farihan MY, Aishah Hani A, Nazarudin S, Ahmad Firdaus MS, Mohd Khadri S. 2021. Comparative Analyses On Synthetic Membranes For Artificial Blood Feeding Of Aedes Aegypti Using Digital Thermo Mosquito Blood Feeder (DITMOF). -Pertanika Journal Of Science & Technology. 2073-2086. |
| 19 | Dr. Zulkarnain Md Idris | zulkarnain.mdidris@ukm.edu.my | Malaria, Parasite Epidemiology, Modelling Transmission | https://www.scopus.com/authid/detail.uri?authorId=55151560300 | https://scholar.google.com/citations?user=GJrQlZsAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxOTMzNg== | Idris ZM, Chan CW, Kongere J, Gitaka J, Logedi J, Omar A, Obonyo C, Machini BK, Isozumi R, Teramoto I, Kimura M, Kaneko A. High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya. Sci Rep. 2016 Nov 14;6:36958. doi: 10.1038/srep36958. |
| 20 | Dr. Wathiqah Wahid | wathiqah.wahid@ppukm.ukm.edu.my | Clinical Parasitology, Medical Parasitology | https://www.scopus.com/authid/detail.uri?authorId=57211282831 | https://scholar.google.com/citations?user=_gbyIFQAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAyMTg1MA | Wahid W, Ahmad Fahmi NA, Mohd Salleh AF, Mohd Yasin ‘. Bronchopulmonary lophomoniasis: A rare cause of pneumonia in an immunosuppressed host. Respir Med Case Rep. 2019 Oct 11;28:100939. doi: 10.1016/j.rmcr.2019.100939. PMID: 31667075; PMCID: PMC6812266. |
| 21 | Dr. Asiyah Nordin | asiyah.nordin@ppukm.ukm.edu.my | https://ukmsarjana.ukm.my/main/lihat_profil/SzAyMDMxNA== | ||||
| 22 | Dr. Jauhary Effendy Juma’at | jauhary@ukm.edu.my | https://ukmsarjana.ukm.my/main/lihat_profil/SzAyMjM0Mg== | ||||
| 23 | Dr. Muttaqillah Najihan Abdul Samat | muttaqillah@ppukm.ukm.edu.my | https://scholar.google.com/citations?user=ELGOfTwAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxNTM4NA== | Mohd Azrul Hisham Ismail, Norhidayah Kamarudin, Muttaqillah Najihan Abdul Samat, Raja Mohd Fadhil Raja Abdul Rahman, Saberi Saimun, Toh Leong Tan And Hui-Min Neoh. (2021). Methicillin-Resistant Staphylococcus Aureus (Mrsa) Clonal Replacement In A Malaysian Teaching Hospital: Findings From An Eight-Year Interval Molecular Surveillance. – Antibiotics. 1-10. | ||
| 24 | Dr. Sharifah Azura Salleh | drazura@ppukm.ukm.edu.my | https://scholar.google.com/citations?user=cq1mUNkAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMDg2Ng== | Aishah Hani Azil, Umi Kalsom Ali, Azlin Mohd Yasin, Sharifah Azura Salleh. (2021). Awareness And Preparedness Of Healthcare Workers Against The First Wave Of The Covid-19 Pandemic: A Cross-Sectional Survey Across 57 Countries. – Plos One. 1-29. | ||
| 25 | Dr. Siti Norlia Othman | ctnorlia@ppukm.ukm.edu.my | https://scholar.google.com/citations?user=-w9fJkUAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMzg2MA== | Zetti Zainol Rashid, Siti Norlia Othman, Muttaqillah Najihan Abdul Samat, Umi Kalsom Ali, Wong Kon Ken. (2020). Diagnostic Performance Of Covid-19 Serology Assays. – Malaysian Journal Of Pathology. 13-21. | ||
| 26 | Dr. Umi Kalsom @ Satariah Ali | satariah@ppukm.ukm.edu.my | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMzkyOA== | Petrick Periyasamy, Ng Boon Hau, Umi Kalsom Satariah Ali, Zetti Zainol Rashid, Najma Kori. (2021). Aerosolized Sars-Cov-2 Transmission Risk: Surgical Or N95 Masks?. – Infection Control & Hospital Epidemiology. 1150-1152. | |||
| 27 | Dr. Wong Kon Ken | wkk@ppukm.ukm.edu.my | Virology & infectious diseases (Epidemiology and Strain sequence heterogeneity of respiratory viruses in humans) | https://www.scopus.com/authid/detail.uri?authorId=55821342300 | https://scholar.google.com/citations?user=Xk6AtEsAAAAJ | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMjkyMQ== | Kon Ken Wong, Shaun Wen Huey Lee, Kok Pim Kua. (2021). N-Acetylcysteine As Adjuvant Therapy For Covid-19 – A Perspective On The Current State Of The Evidence. – Journal Of Inflammation Research. 2993-3013. |
| 28 | Dr. Zalina Ismail | zalina.ismail@ppukm.ukm.edu.my | https://scholar.google.com.my/citations?user=zUvuGDIAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxMDU4NQ== | Zalina Ismail, Siti Fatimah Abdullah, Asrul Abdul Wahab, Tuan Suhaila Tuan Soh, Anita Sulong. (2021). Modified Carbapenem Inactivation Method (Mcim) For Detection Of Carbapenemase Production In Klebsiella Spp. – International Journal Of Infectious Diseases. | ||
| 29 | Dr. Adli Ali | adli.ali@ppukm.ukm.edu.my | https://scholar.google.com.my/citations?user=1FXMAGUAAAAJ&hl=en | https://ukmsarjana.ukm.my/main/lihat_profil/SzAxNjcwMA== | Leire Solis, Julia Nordin, Johan Prevot, Nizar Mahlaoui, Silvia Sanchez Ramon, Adli Ali, Elodie Cassignol, John W Seymour, Martine Pergent. (2022). The Pid Life Index: An Interactive Tool To Measure The Status Of The Pid Healthcare Environment In Any Given Country. – Orphanet Journal Of Rare Diseases. 1-8. | ||
| 30 | Dr. Najma Kori | najmakori@ukm.edu.my | Infectious Diseases | https://ukmsarjana.ukm.my/main/lihat_profil/SzAyMjQ0Nw== | Petrick Periyasamy, Ng Boon Hau, Umi Kalsom Satariah Ali, Zetti Zainol Rashid, Najma Kori. (2021). Aerosolized Sars-Cov-2 Transmission Risk: Surgical Or N95 Masks?. – Infection Control & Hospital Epidemiology. 1150-1152. | ||
We are looking for Postgraduate Master or PhD Students and Post-doctoral fellow who are highly motivated and who are curious to know more about infectious diseases. If you are interested to join our team, please contact:
Name: Assoc. Prof. Dr. Alfizah Hanafiah (Group leader)
Email: alfizah@ppukm.ukm.edu.my
PLACENTA AND PERINATAL RESEARCH
RESEARCH INTERESTS
Our research group consists of neonatologist, perinatal/placenta pathologist, obstetricians, scientists, microbiologist and statisticians. We have generated an animal model for intrapartum Gardnerella vaginalis infection, and found that baby rabbit with GV infection were smaller than the non-infected counterpart. Interestingly, we also found that the placental multinucleated cells were increased in GV infection. Our current study investigates the effects of GV infection on growth-related hormones in placenta. In addition, we are studying the lung morphometry and histopathological changes of rabbit babies with GV infection. Our group is also investigating the biomarkers and microRNA expression of hydatidiform mole, chorioamnionitis and funisitis.
MEMBERS OF RESEARCH GROUP
- Prof Dr Cheah Fook Choe (cheahfc@ppukm.ukm.edu.my) Neonatologist SCOPUS, Google Scholar, UKM
- Prof Dr Tan Geok Chin (tangc@ppukm.ukm.edu.my) Pathologist SCOPUS, Google Scholar, UKM
- Prof Dr Lim Pei Shan (pslim@ppukm.ukm.edu.my) Obstetrician SCOPUS, Google Scholar, UKM
- AProf Dr Wong Yin Ping (ypwong@ppukm.ukm.edu.my) Pathologist SCOPUS, Google Scholar, UKM
- AProf Dr Ng Beng Kwang (nbk9955@ppukm.ukm.edu.my) Obstetrician SCOPUS, Google Scholar, UKM
- AProf Dr Shareena Ishak (shareena@ppukm.ukm.my) Neonatologist SCOPUS, Google Scholar, UKM
- AProf Dr Nirmala Kampan (nirmala@ppukm.ukm.edu.my) Obstetrician SCOPUS, Google Scholar, UKM
- AProf Dr Rosnah Sutan (rosnah_sutan@yahoo.com) Public health Physician SCOPUS, Google Scholar, UKM
- Dr Nor Haslinda Abdul Aziz (norhaslinda.abdaziz@ppukm.ukm.edu.my) PhD in Clinical Medicine, SCOPUS, Google Scholar, UKM
- Dr Wong Kon Ken (wkk@ppukm.ukm.edu.my) Microbiologist SCOPUS, Google Scholar, UKM
We are looking for Postgraduate Master or PhD Students and Post-doctoral fellow who are highly motivated and who are curious to know more about diseases occurring during perinatal period. If you are interested to join our team, please contact:
Name: Prof. Dr. Cheah Fook Choe (Group leader)
Email: cheahfc@ppukm.ukm.edu.my
SELECTED PUBLICATIONS
1: Wong YP, Tan GC, Wong KK, Anushia S, Cheah FC. Gardnerella vaginalis in perinatology: An overview of the clinicopathological correlation. Malays J Pathol. 2018 Dec;40(3):267-286.
2: Chew BS, Ghazali R, Othman H, Ismail NAM, Othman AS, Laim NMST, Wong YP, Tan GC. Endocan expression in placenta of women with hypertension. J Obstet Gynaecol Res. 2019 Feb;45(2):345-351.
3: Azliana AF, Zainul-Rashid MR, Chandramaya SF, Farouk WI, Nurwardah A, Wong YP, Tan GC. Vascular endothelial growth factor expression in placenta of hypertensive disorder in pregnancy. Indian J Pathol Microbiol. 2017 Oct- Dec;60(4):515-520.
4: Tan GC, Chan E, Molnar A, et al. 5′ isomiR variation is of functional and evolutionary importance. Nucleic Acids Res. 2014 Aug;42(14):9424-35.
5: Tan GC, Dibb N. IsomiRs have functional importance. Malays J Pathol. 2015 Aug;37(2):73-81.
6: Harwood DT, Darlow BA, Cheah FC, McNeill N, Graham P, Winterbourn CC. Biomarkers of neutrophil-mediated glutathione and protein oxidation in tracheal aspirates from preterm infants: association with bacterial infection. Pediatr Res. 2011 Jan;69(1):28-33.
7: Pillow JJ, Hillman NH, Polglase GR, Moss TJ, Kallapur SG, Cheah FC, Kramer BW, Jobe AH. Oxygen, temperature and humidity of inspired gases and their influences on airway and lung tissue in near-term lambs. Intensive Care Med. 2009 Dec;35(12):2157-63.
8: Kallapur SG, Nitsos I, Moss TJ, Polglase GR, Pillow JJ, Cheah FC, Kramer BW, Newnham JP, Ikegami M, Jobe AH. IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide. Am J Respir Crit Care Med. 2009 May 15;179(10):955-61.
9: Cheah FC, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L384-93.
MySepsis
RESEARCH INTERESTS
MySepsis group was found in 2013 as an initiative to provide continuous education and updates on the management of sepsis to Malaysian healthcare professionals. The MySepsis group consists of a multidisciplinary team which includes clinicians, scientists and researchers from the Faculty of Medicine, Faculty of Engineering and School of Chemistry of UKM. We are also actively involved in fundamental research of sepsis pathology, with the aim to translate laboratory findings to better bedside diagnostics and management. Our team members are actively involved in research on sepsis biomarkers, antimicrobial resistance and POCT (point of care test) development. Using a transdisciplinary approach, we are currently developing a rapid, portable sepsis diagnosis kit to be used beyond the emergency department and primary healthcare setting e.g. in natural disasters and war-afflicted regions where sepsis readily occurs but is challenging to diagnose and treat. The idea for this sepsis diagnosis kit has been filed for patent and its prototype is currently being developed. MySepsis is committed to provide the best evidence-based care to sepsis patients. Our group aim to provide insights in identifying sepsis and highlight the burden of this disease. Looking at recent epidemics and pandemics around the world, it is critical that healthcare professionals are familiar in dealing with infectious disease outbreaks. The path of sepsis evolution is built on discussion in dilemmas while treating sepsis and the reintroduction of a systematic approach in managing sepsis. “Sepsis Evolution: Recognize. Rectify”.
MEMBERS OF RESEARCH GROUP
We are looking for Postgraduate Master or PhD Students and Post-doctoral fellow who are highly motivated and who are curious to know more about Sepsis. If you are interested to join our team, please contact:
Name: Assoc Prof Dr Tan Toh Leong (Group leader)
Email: sebastianttl@yahoo.co.uk
PUBLICATIONS
- “CD64 and group II secretory phospholipase A2 (sPLA2-IIA) as biomarkers for distinguishing adult sepsis and bacterial infections in the emergency department. TL Tan, NS Ahmad, DN Nasuruddin, A Ithnin, K Tajul Arifin, IZ Zaini. PLoS One 11 (3), e0152065”
- “An Amperometric Biosensor for the Determination of Bacterial Sepsis Biomarker, Secretory Phospholipase Group 2-IIA Using a Tri-Enzyme System. NN Nik Mansor, TL Tan, E Safitri, D Futra, NS Ahmad, DN Nasuruddin. Sensors 18 (3), 686”
- “The role of group IIA secretory phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults—A systematic reviewTL Tan, YY Goh. PloS one 12 (7), e0180554”
- “Pulsed-field gel electrophoresis (PFGE): A review of the “gold standard” for bacteria typing and current alternatives. H Neoh, XE Tan, HF Sapri, TL Tan. Infection, Genetics and Evolution 74, 103935”
- “Comparison of Prognostic Accuracy of the quick Sepsis-Related Organ Failure Assessment (qSOFA) between Short- & Long-term Mortality in Patients Presenting Outside of the ICU Setting. TL Tan, YJ Tang, LJ Ching, N Abdullah, HM Neoh. Scientific Reports 8, 16698”
- “Antimicrobial resistance profiling and molecular typing of methicillin-resistant Staphylococcus aureus isolated from a Malaysian teaching hospitalA Noordin, HF Sapri, NAM Sani, SK Leong, XE Tan, TL Tan, NM Zin. Journal of Medical microbiology 65 (12), 1476-1481”
- “The 28-Day Mortality Prediction in Sepsis Patients Using Static Lactate Concentration and Early Lactate Clearance: An Observational StudyToh Leong Tan, Noor Asmidar, Wei Jie Ong, Ahmad Fuad Fahmi, Zhin Liang. Medicine & Health Journal 9 (2), 124-133”
- “Comparative proteomics profiling reveals down-regulation of Staphylococcus aureus virulence in achieving intermediate vancomycin resistanceX Tan, H Neoh, M Loo, TL Tan, S Hussin, L Cui, K Hiramatsu, R Jamal. Malaysian Journal of Microbiology 12 (6), 498-505”
- “Advantages and Limitations of 16S rRNA Next-Generation Sequencing for Pathogen Identification in the Diagnostic Microbiology Laboratory: Perspectives from a Middle-Income Country. NS Muhamad Rizal, H Neoh, R Ramli, A Hanafiah, MN Abdul Samat. Diagnostics 10 (10), 816”
- “Molecular surveillance of methicillin-susceptible Staphylococcus aureus (MSSA) isolated over a one-year period from a Malaysian Teaching HospitalHF Sapri, MAH Ismail, NAM Sani, A Noordin, TL Tan, S Hussin, H Neoh. Germs 10 (2), 104”
- “High sPLA2-IIA level is associated with eicosanoid metabolism in patients with bacterial sepsis syndromeNS Ahmad, TL Tan, KT Arifin, WZW Ngah, YAM Yusof. PloS one 15 (3), e0230285”
- “Sepsis Management: A Quick Guide. TL Tan, JY Lim. Malaysian Sepsis Alliance”
- “Rapid Detection of Sepsis using CESDA: The Caenorhabditis elegans Sepsis Detection Assay.LF Tee, TL Tan, H Neoh, R Jamal. Revista da Sociedade Brasileira de Medicina Tropical 52”
- “Sepsis: The New Insight. TL Tan, NH Ahmad, HM Neoh. ISBN 9789674127398 1,1-64”
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