Placenta And Perinatal Research
RESEARCH INTERESTS

Our research group consists of neonatologist, perinatal/placenta pathologist, obstetricians, scientists, microbiologist and statisticians. We have generated an animal model for intrapartum Gardnerella vaginalis infection, and found that baby rabbit with GV infection were smaller than the non-infected counterpart. Interestingly, we also found that the placental multinucleated cells were increased in GV infection. Our current study investigates the effects of GV infection on growth-related hormones in placenta. In addition, we are studying the lung morphometry and histopathological changes of rabbit babies with GV infection. Our group is also investigating the biomarkers and microRNA expression of hydatidiform mole, chorioamnionitis and funisitis.

MEMBERS OF RESEARCH GROUP
No.NameEmailExpertiseUKMSarjanaGoogle ScholarScopus
1Prof. Dr. Cheah Fook Choe cheahfc@ppukm.ukm.edu.myNeonatologistUKMGoogle ScholarScopus
2Prof. Dr. Tan Geok Chintangc@ppukm.ukm.edu.myPathologistUKMGoogle ScholarScopus
3Prof. Dr. Lim Pei Shan pslim@ppukm.ukm.edu.myObstetricianUKMGoogle ScholarScopus
4Assoc. Prof. Dr. Wong Yin Pingypwong@ppukm.ukm.edu.myPathologistUKMGoogle ScholarScopus
5Assoc. Prof. Dr. Ng Beng Kwangnbk9955@ppukm.ukm.edu.myObstetricianUKMGoogle ScholarScopus
6Assoc Prof. Dr. Shareena Ishak shareena@ppukm.ukm.myNeonatologistUKMGoogle ScholarScopus
7Assoc. Prof. Dr. Nirmala Kampan nirmala@ppukm.ukm.edu.myObstetricianUKMGoogle ScholarScopus
8Assoc. Prof. Dr. Rosnah Sutanrosnah_sutan@yahoo.comPublic health Physician UKMGoogle ScholarScopus
9Dr. Nor Haslinda Abdul Aziz norhaslinda.abdaziz@ppukm.ukm.edu.myPhD in Clinical MedicineUKMGoogle ScholarScopus
10Dr. Wong Kon Kenwkk@ppukm.ukm.edu.myMicrobiologistUKMGoogle ScholarScopus

We are looking for Postgraduate Master or PhD Students and Post-doctoral fellow who are highly motivated and who are curious to know more about diseases occurring during perinatal period. If you are interested to join our team, please contact:

Name: Prof. Dr. Cheah Fook Choe (Group leader)

Email: cheahfc@ppukm.ukm.edu.my

 
PUBLICATIONS

1: Wong YP, Tan GC, Wong KK, Anushia S, Cheah FC. Gardnerella vaginalis in perinatology: An overview of the clinicopathological correlation. Malays J Pathol. 2018 Dec;40(3):267-286.

2: Chew BS, Ghazali R, Othman H, Ismail NAM, Othman AS, Laim NMST, Wong YP, Tan GC. Endocan expression in placenta of women with hypertension. J Obstet Gynaecol Res. 2019 Feb;45(2):345-351.

3: Azliana AF, Zainul-Rashid MR, Chandramaya SF, Farouk WI, Nurwardah A, Wong YP, Tan GC. Vascular endothelial growth factor expression in placenta of hypertensive disorder in pregnancy. Indian J Pathol Microbiol. 2017 Oct- Dec;60(4):515-520.

4: Tan GC, Chan E, Molnar A, et al. 5′ isomiR variation is of functional and evolutionary importance. Nucleic Acids Res. 2014 Aug;42(14):9424-35.

5: Tan GC, Dibb N. IsomiRs have functional importance. Malays J Pathol. 2015 Aug;37(2):73-81.

6: Harwood DT, Darlow BA, Cheah FC, McNeill N, Graham P, Winterbourn CC. Biomarkers of neutrophil-mediated glutathione and protein oxidation in tracheal aspirates from preterm infants: association with bacterial infection. Pediatr Res. 2011 Jan;69(1):28-33.

7: Pillow JJ, Hillman NH, Polglase GR, Moss TJ, Kallapur SG, Cheah FC, Kramer BW, Jobe AH. Oxygen, temperature and humidity of inspired gases and their influences on airway and lung tissue in near-term lambs. Intensive Care Med. 2009 Dec;35(12):2157-63.

8: Kallapur SG, Nitsos I, Moss TJ, Polglase GR, Pillow JJ, Cheah FC, Kramer BW, Newnham JP, Ikegami M, Jobe AH. IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide. Am J Respir Crit Care Med. 2009 May 15;179(10):955-61.

9: Cheah FC, Pillow JJ, Kramer BW, Polglase GR, Nitsos I, Newnham JP, Jobe AH, Kallapur SG. Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis. Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L384-93.