Tissue Engineering And Regenerative Medicine
RESEARCH INTERESTS
Tissue engineering and regenerative medicine (TERM) research group is concerned with the natural self-healing capacities of the body and seeks to harness this regenerative property by integrating stem cell technologies, biomaterials and engineering solutions to reconstruct, replace or rejuvenate injured organs and tissues. The current TERM research group consists of multidisciplinary researchers who are clinicians, basic scientists, translational scientists as well as engineers. They are interested in a few niche areas such as cardiovascular bioengineering, airway bioengineering, stem cell technology & derivatives, functional biomaterials & nanotechnology, neuro-skeletal bioengineering, biosignalling, urogenital bioengineering, cutaneous tissue engineering, oral & maxillofacial tissue engineering and ocular tissue engineering. The team has embarked on a range of initiatives aimed at delivering therapeutic solutions though tissue engineering technology. Stem cells such as induced pluripotent stem cells and mesenchymal stem cells and its secretory products such as exosomes are used to study cell biology, to screen drug toxicity, to develop in vitro model for testing purposes as well as to understand and treat diseases. Nature inspired functional biomaterials such as fibrin, ovine collagen type I, gelatin, poultry elastin, bacterial cellulose and many more were used as scaffold for tissue engineering or as carrier for biologics. The team has a translational focus and a number of clinical studies have been initiated. For example, a clinical phase II trial on tissue-engineered skin substitutes using cultured autologous skin cells with the patient’s serum has been conducted in 2014-2018. Tissue-engineered bone composed of autologous mesenchymal stromal cells on ceramic graft and platelet-rich plasma have been applied clinically for bone non-union cases. Besides, tissue-engineered cornea has been used to replace a chemically injured cornea of a patient. Currently, a clinical phase II trial is underway using mesenchymal stromal cells for osteoarthritis of the knee.
TERM research group members are affiliated with the Centre of Tissue Engineering & Regenerative Medicine (CTERM) (https://www.ukm.my › ctermfper) located at the 12th floor, Clinical Block of the UKM Medical Centre. CTERM is the home office for the Tissue Engineering & Regenerative Medicine Society (TESMA) (https://tesma.org.my/), a national body with over 100 active members composed of academic & industrial researchers from all over Malaysia. TESMA is affiliated with the International Society with more than a thousand members i.e. TERMIS (https://termis.org/).
MEMBERS OF RESEARCH GROUP
No. | Name | Research niche | UKM | Google Scholar | Scopus | |
1 | Prof. Madya Dr. Angela Ng Min Hwei | angela@ppukm.ukm.edu.my | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
2 | Dr. Law Jia Xian | lawjx@ppukm.ukm.edu.my | stem cell technology & derivatives | UKM | Google Scholar | Scopus |
3 | Dr. Mohd Fauzi Bin Mh Busra | fauzibusra@ukm.edu.my | functional biomaterials & nanotechnology | UKM | Google Scholar | Scopus |
4 | Prof. Madya Dr. Yogeswaran A/L Lokanathan | lyoges@ppukm.ukm.edu.my | airway bioengineering | UKM | Google Scholar | Scopus |
5 | Puan Nur Atiqah Haizum Binti Abdullah | atiqah.haizum@ukm.edu.my | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
6 | Dr. Manira Binti Maarof | manira@ppukm.ukm.edu.my | cutaneous tissue engineering | UKM | Google Scholar | Scopus |
7 | Dr. Nadiah Binti Sulaiman | nadiahsulaiman@ukm.edu.my | cardiovascular bioengineering | UKM | Google Scholar | Scopus |
8 | Prof. Madya Dr. Nor Hazla Binti Mohamed Haflah | hazla1971@yahoo.com | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
9 | Dr. Ekram Bin Alias | ekram.alias@ppukm.ukm.edu.my | functional biomaterials & nanotechnology | UKM | Google Scholar | Scopus |
10 | Prof. Madya Dr. Nor Hamdan Bin Mohamad Yahaya | nhmycj@gmail.com | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
11 | Dr. Mohd Heikal Bin Mohd Yunus | mohdheikalyunus@ppukm.ukm.edu.my | cutaneous tissue engineering | UKM | Google Scholar | Scopus |
12 | Prof. Madya Dr. Chua Kien Hui | ckienhui@ppukm.ukm.edu.my | stem cell technology & derivatives | UKM | Google Scholar | Scopus |
13 | Prof. Ir. Dr. Abu Bakar Bin Sulong | abubakar@ukm.edu.my | functional biomaterials & nanotechnology | UKM | Google Scholar | Scopus |
14 | Mej. Bersekutu (Pa) Prof. Madya Dr. Mohd Yazid Bin Bajuri | ezeds007@yahoo.com.my | cutaneous tissue engineering | UKM | Google Scholar | Scopus |
15 | Prof. Madya Dr. Shalimar Binti Abdullah | kelapa44@yahoo.com | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
16 | Prof. Dr. Nur Azurah Binti Abdul Ghani | nurazurahag@gmail.com | Urogenital bioengineering &stem cell technology | UKM | Google Scholar | Scopus |
17 | Prof. Madya Dr. Jemaima Binti Che Hamzah | jemaima@ppukm.ukm.edu.my | Ocular tissue engineering | UKM | Google Scholar | Scopus |
18 | Prof. Madya Dr. Ohnmar Htwe @ Rashidah Binti Ismail | htwe.om@gmail.com | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
19 | Dr. Ng Sook Luan | ngsookluan@ukm.edu.my | oral & maxillofacial tissue enginnering | UKM | Google Scholar | Scopus |
20 | Dr. Fazlina Binti Nordin | nordinf@ppukm.ukm.edu.my | stem cell technology & derivatives | UKM | Google Scholar | Scopus |
21 | Prof. Dr. Amaramalar Selvi Naicker | asnaicker@yahoo.com | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
22 | Prof. Madya Dr. Wan Haslina Binti Wan Abdul Halim | afifiyad@yahoo.co.uk | Ocular tissue engineering | UKM | Google Scholar | Scopus |
23 | Dr. Rizal Bin Abd Rani | rizal@ppukm.ukm.edu.my | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
24 | Prof. Madya Dr. Farrah Hani Binti Imran | farrahhani@ukm.edu.my | cutaneous tissue engineering | UKM | Google Scholar | Scopus |
25 | Dr. Taty Anna Binti Kamarudin | tatykamarudin@ukm.edu.my | stem cell technology & derivatives | UKM | Google Scholar | Scopus |
26 | Dr. Muhammad Da`In Bin Yazid | dain@ukm.edu.my | biosignalling | UKM | Google Scholar | Scopus |
27 | Prof. Dr. Roszalina Bt. Ramli | roszalina@ppukm.ukm.edu.my | oral & maxillofacial tissue enginnering | UKM | Google Scholar | Scopus |
28 | Dr. Nahdia Afiifah Binti Abdul Jalil | nahdia.afiifah@ukm.edu.my | Ocular tissue engineering | UKM | Google Scholar | Scopus |
29 | Prof. Dr. Mae-Lynn Catherine Bastion | mae-lynn@ppukm.ukm.edu.my | Ocular tissue engineering | UKM | Google Scholar | Scopus |
30 | Dr. Isma Liza Binti Mohd Isa | ismaliza84@gmail.com | functional biomaterials & nanotechnology | UKM | Google Scholar | Scopus |
31 | Dr. Muhamad Ramdzan Bin Buyong | muhdramdzan@ukm.edu.my | functional biomaterials & nanotechnology | UKM | Google Scholar | Scopus |
32 | Dr. Law Zhe Kang | zhe.kanglaw@ppukm.ukm.edu.my | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
33 | Dr. Steve Ng Chen Fei | ngchenfei@ppukm.ukm.edu.my | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
34 | Prof. Madya Dr. Jamari Bin Sapuan | drjamari@ppukm.ukm.edu.my | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
35 | Dr. Muhammad Kamal Bin Muhammad Abdul Jamil | drkortho@gmail.com | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
36 | Lt. Kol. Bersekutu (Pa) Prof. Dato’ Dr. Zulkifli Bin Md. Zainuddin | zuluro@ppukm.ukm.edu.my | Urogenital bioengineering | UKM | Google Scholar | Scopus |
37 | Dr. Brenda Saria Binti Yuliawiratman | bsaria@yahoo.com | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
38 | Dr. Mohamad Azim Bin Md Idris | Azim@ppukm.ukm.edu.my | cutaneous tissue engineering | UKM | Google Scholar | Scopus |
39 | Prof. Madya Dr. Mawaddah Binti Azman | mawaddah@ukm.edu.my | airway bioengineering | UKM | Google Scholar | Scopus |
40 | Puan Rohaina Binti Che Man | rohaina@ppukm.ukm.edu.my | cardiovascular bioengineering | UKM | Google Scholar | Scopus |
41 | Prof. Datuk Dr. Sabarul Afian Bin Mokhtar | drsam@ppukm.ukm.edu.my | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
42 | Prof. Madya Dato’ Dr. Nik Ritza Kosai Bin Nik Mahmood | nikkosai@yahoo.co.uk | stem cell technology & derivatives | UKM | Google Scholar | Scopus |
43 | Prof. Dr. Goh Bee See | beesee@ppukm.ukm.edu.my | airway bioengineering | UKM | Google Scholar | Scopus |
44 | Prof. Madya Dr. Rabani Binti Remli | rabaniremli@ppukm.ukm.edu.my | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
45 | Prof. Dr. Marina Binti Mat Baki | marinamatbaki@ppukm.ukm.edu.my | airway bioengineering | UKM | Google Scholar | Scopus |
46 | Encik Mohd Rafizul Bin Mohd Yusof | rafizulyusof@ukm.edu.my | Animal modelling in TERM research | UKM | Google Scholar | Scopus |
47 | Encik Mohd Hairul Nizam Bin Harun | hairulnizam@ppukm.ukm.edu.my | Ocular tissue engineering | UKM | Google Scholar | Scopus |
48 | Dr. Rabiatul Adawiyah Binti Razali | rabiatularzl@ukm.edu.my | airway bioengineering & natural extracts in TERM | UKM | Google Scholar | Scopus |
49 | Encik Shamsul Bin Sulaiman | shamsulsulaiman80@gmail.com | neuro-skeletal bioengineering | UKM | Google Scholar | Scopus |
50 | Dr. Nur Izzah Md Fadilah | izzahfadilah@ukm.edu.my | cutaneous tissue engineering & functional biomaterials | UKM | Google Scholar | Scopus |
51 | Encik Mohd Asyraf Bin Mat Afandi | asyrafafandi@ukm.edu.my | muscular tissue engineering | UKM | Google Scholar | Scopus |
52 | Puan Nazeha Binti Ahmat | nazehaahmat@ukm.edu.my | ISO & GMP Quality standards CGTP | UKM | Google Scholar | Scopus |
53 | Encik Muhammad Najib Fathi Bin Hassan | najibfathi93@gmail.com | stem cell technology & bioreactor | UKM | Google Scholar | Scopus |
54 | Encik Mohamad Fikeri Bin Ishak | fikeri_ishak@yahoo.com | cardiovascular bioengineering | UKM | Google Scholar | Scopus |
55 | Puan Seet Wan Tai | wtseet@ppukm.ukm.edu.my | ISO & GMP Quality standards CGTP | UKM | Google Scholar | Scopus |
PUBLICATIONS
- Zahra Rashidbenam, Mohd Hafidzul Jasman, Guan Hee Tan, Eng Hong Goh, Xeng Inn Fam, Christopher Chee Kong Ho, Zulkifli Md Zainuddin, Reynu Rajan, Rizal Abdul Rani, Fatimah Mohd Nor, Mohamad Aznan Shuhaili, Nik Ritza Kosai, Farrah Hani Imran, Min Hwei Ng. (2021). Fabrication Of Adipose-Derived Stem Cell-Based Self-Assembled Scaffold Under Hypoxia And Mechanical Stimulation For Urethral Tissue Engineering. – International Journal Of Molecular Sciences. 1-32.
- Shamsul Bin Sulaiman, Shiplu Roy Chowdhury, Mohd Fauzi Bin Mh Busra, Rizal Bin Abdul Rani, Nor Hamdan Bin Mohamad Yahaya, Yasuhiko Tabata, Yosuke Hiraoka, Ruszymah Binti Haji Idrus, Ng Min Hwei. (2021). Type II Collagen-Conjugated Mesenchymal Stem Cells Micromass For Articular Tissue Targeting. – Biomedicines. 1-17.
- Khairunnisa Ramli, Aminath Ifasha G, Amir Adham Ahmad, Ohnmar Htwe, Nor Hazla Mohamed Haflah, Zhe Kang Law, Shariful Hasan, Amaramalar Selvi Naicker, Sabarul Afian Mokhtar, Mohd Hisam Ma, Azmi Baharudin, Geok Chin Tan, Ruszymah Bhi, Shalimar A, Mh Ng Mh. (2019). Efficacy Of Human Cell-Seeded Muscle-Stuffed Vein Conduit In Rat Sciatic Nerve Repair. – Tissue Engineering-Part A. 1438-1455.
- Hiba A Alsaeedi, Avin E Koh, Chenshen Lam, Munirah A Rashid, Mohd Hairul Nh, Muhamad Fakhri Ms, Sw Teh, Chi D Luu, Mh Ng, Hazlita Mohd Isa, Sn Leow, Ky Then, Mae-Lynn C Bastion, Pl Mok, Bala Sundaram M, Antony V Samrot, Kb Swamy, Jaikumar N, Suresh S K. (2019). Dental Pulp Stem Cells Therapy Overcome Photoreceptor Cell Death And Protects The Retina In A Rat Model Of Sodium Iodate-Induced Retinal Degeneration. – Journal Of Photochemistry And Photobiology, B: Biology. 1-8.
- Lohashenpahan Shanmuganantha , Azmi Baharudin , Abu Bakar Sulong , Roslinda Shamsudin And Min Hwei Ng. (2021). Prospect Of Metal Ceramic (Titanium-Wollastonite) Composite As Permanent Bone Implants: A Narrative Review. – Materials. 1-24.
- Mohd Yazid Bajuri, Nanchappan Selvanathan, Fatin Nadira Dzeidee Schaff, Muhammad Haziq Abdul Suki & Angela Min Hwei Ng. (2021). Tissue-Engineered Hydroxyapatite Bone Scaffold Impregnated With Osteoprogenitor Cells Promotes Bone Regeneration In Sheep Model. – Tissue Engineering And Regenerative Medicine. 377-385.
- Rohaina Che Man, Then Kong Yong, Ng Min Hwei, Wan Haslina Wan Abdul Halim, Aida Zairani Mohd Zahidin, Roszalina Ramli, Aminuddin Bin Saim, Ruszymah Binti Hj Idrus. (2017). Corneal Regeneration By Induced Human Buccal Mucosa Cultivated On An Amniotic Membrane Following Alkaline Injury. – Molecular Vision. 810-822.
- Thayaalini Subramaniam, Nursharafana Shaiful Hadi, Shamsul Sulaiman, Mh Busra Fauzi, Ruszymah Bt Hj Idrus, Shiplu Roy Chowdhury, Jia Xian Law, Manira Maarof. (2021). Comparison of three different skin substitutes in promoting wound healing in an ovine model. – Burns.
- James Jam Jolly, Nur Farhana Mohd Fozi, Kok-Yong Chin, Sok Kuan Wong, Kien Hui Chua, Ekram Alias, Nur Sabariah Adnan, Soelaiman Ima‑Nirwana. (2021). Skeletal microenvironment system utilising bovine bone scaffold co‑cultured with human osteoblasts and osteoclast‑like cells. Exp Ther Med 22: 680.
- Muhammad Fairuz Azmi, Norzana Abd Ghafar, Jemaima Che Hamzah, Kien Hui Chua, Sook Luan Ng. (2021). The role of Gelam honey in accelerating reepithelialization of ex vivo corneal abrasion model. Journal of Food Biochemistry, 45(4).
- Jegadevswari Selvarajah, Mohd Fauzi Mh Busra, Aminuddin Bin Saim, Ruszymah Bt Hj Idrus & Yogeswaran Lokanathan. (2020). Development and Physicochemical Analysis of Genipin-Crosslinked Gelatine Sponge as a Potential Resorbable Nasal Pack, Journal of Biomaterials Science, Polymer Edition.
- Hanita Mohd Hussin, Mahazura Mat Lawi, Nor Hazla Mohamed Haflah, Abdul Yazid Mohd Kassim, Ruszymah Bt Hj Idrus, Yogeswaran Lokanathan. (2020). Centella asiatica (L.)-Neurodifferentiated Mesenchymal Stem Cells Promote the Regeneration of Peripheral Nerve. Tissue Eng Regen Med 17, 237–251.
- Alia Md Yusof, Norzana Abd Ghafar, Taty Anna Kamarudin, Kien-Hui Chua, Muhammad Fairuz Azmi, Sook-Luan Ng, Yasmin Anum Mohd Yusof. (2019). Gelam honey promotes ex vivo corneal fibroblasts wound healing. Cytotechnology 71, 1121–1135.
- Nadiah S Sulaiman, Andrew R Bond, Vito D Bruno, John Joseph, Jason L Johnson, M-Saadeh Suleiman, Sarah J George, Raimondo Ascione. (2021). Effective decellularisation of human saphenous veins for biocompatible arterial tissue engineering applications: Bench optimisation and feasibility in vivo testing. Journal of Tissue Engineering, 12, 1-14.
- Yogeswaran Lokanathan, Mh Busra Fauzi, Rohaina Che Man, Zahra Rashidbenam, Aminuddin Bin Saim, Ruszymah Binti Hj Idrus And Mohd Heikal Mohd Yunus. (2021). Preliminary Study On The Development Of In Vitro Human Respiratory Epithelium Using Collagen Type I Scaffold As A Potential Model For Future Tracheal Tissue Engineering. – Applied Sciences. 1-12.
- Adila A Hamid, Satish Vaarman Jeyabalan, Aleza Omar, Nik Zattil Hanan Mohd Yasin, Wong Tzeng Lin, Liau Ling Ling, Nur Azurah Abdul Ghani, Aneeza Khairiyah Wan Hamizan & Chua Kien Hui. (2018). Chondrogenesis Of Adipose-Derived Stem Cells With Chondrocytes In Low Serum Towards Clinical Application. – Sains Malaysiana. 2369-2379.
- Mohd Razif Mohd Idris, Fazlina Nordin, Zaleha Abdullah Mahdy, S Fadilah Abd Wahid. (2021). Gestational Diabetes Mellitus in Pregnancy Increased Erythropoietin Level Affecting Differentiation Potency of Haematopoietic Stem Cell of Umbilical Cord Blood. Front Med (Lausanne) 8, 727179.
- Khidhir Kamil, Muhammad Dain Yazid, Ruszymah Bt Hj Idrus, Jaya Kumar. (2020). Hydroxytyrosol Promotes Proliferation of Human Schwann Cells: An In Vitro Study. International Journal of Environmental Research and Public Health, 17(12), 4404.
- Norhashima Abd Rashid, Farida Hussan, Asmah Hamid, Nurul Raudzah Adib Ridzuan, Syarifah Aisyah Syed Abdul Halim, Nahdia Afiifah Abdul Jalil, Nor Haliza Mohamad Najib, Seong Lin Teoh, Siti Balkis Budin. (2020). Polygonum Minus Essential Oil Modulates Cisplatin-Induced Hepatotoxicity Through Inflammatory And Apoptotic Pathways. – Excli Journal. 1246-1265.
- Dilip Thomas, Grazia Marsico, Isma Liza Mohd Isa, Arun Thirumaran, Xizhe Chen, Bartlomiej Lukasz, Gianluca Fontana, Brian Rodriguez, Martina Marchetti-Deschmann, Timothy O’Brien, and Abhay Pandit. (2020). Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose. Proceedings of the National Academy of Sciences, 202008245.
- Nur Mas Ayu Jamaludin, Muhammad Khairulanwar Abdul Rahim, Azrul Azlan Hamzah, Nadiah Abu, Muhamad Ramdzan Buyong. (2020). Rapid Manipulation Of Extracellular Vesicles Using Dielectrophoretic Mechanism. – Sains Malaysiana. 2901-2912.
- Shalimar Abdullah, Azammuddin Alias, Nor Hazla Mohamed-Haflah, Roohi Ahmad, Parminder Singh Gill, Nur Azuatul Akmal Kamaludin, Jamari Sapuan. (2019). Functional Outcome After Successful Revascularisation And Replantation Surgery Of The Fingers, Wrist, Forearm And Arm. – Journal Of Clinical And Diagnostic Research. RC01-RC04.
- Kamal Jamil, Kien-Hui Chua, Samad Joudi, Sook-Luan Ng, Nor Hamdan Yahaya. (2015). Development Of A Cartilage Composite Utilizing Porous Tantalum, Fibrin And Rabbit Chondrocytes For Treatment Of Cartilage Defect. – Journal Of Orthopaedic Surgery And Research. 1-9.
- Henry Tan Cl, Tan Jh, Mohamad Y, Lenny Suryani Safri, Krishna K, Imran Ar, Md Idris Ma, Hanafiah H. (2020). Unexpected Complication Of Arteriovenous Fistula Of The Left Common Carotid To Internal Jugular Vein Following Central Venous Catheterization. – Chinese Journal Of Traumatology. 29-31.
- Nahdia Afiifah Abdul Jalil, Ng Sook Luan, Taty Anna Kamarudin, Nurul Huda Mohd Yusoff, Natasya Nadia Sahruddin And Norzana Abd Ghafar. (2019). Phenotypic Comparison Of Human Corneal Epithelial Htcepi And 10.014 Prsv-T Cell Lines. – Malaysian Anatomical Association Conference (Maac) 2019. 41-42.
- Shalimar Abdullah, Fadzlina Mohtar, Nordashima Abdul Shukor, Jamari Sapuan. (2017). In Vitro Evaluation Of Human Hand Tendon Ingrowth Into A Synthetic Scaffold. – The Journal Of Hand Surgery (Asian-Pacific Volume). 429-434.
- Chen Fei Ng, Rabani Remli. (2021). Bilateral Foot Drop And Cherry Skin Lesion. – European Journal Of Internal Medicine. 82-83.
- Brenda S. Yuliawiratman, Arif Soemarjono, Ohnmar Htwe, And Amaramalar S. Naicker,. (2020). Evaluation Of Pain Relief In Knee Osteoarthritis Using Extracorporeal Shockwave Therapy In Combination With Intra-Articular Platelet Rich Plasma Injection A Case Report. – American Journal Of Physical Medicine And Rehabilitation. A 303.
- Henry Tan Chor Lip, Mohamad Azim Md. Idris, Farrah-Hani Imran, Tuan Nurazmah, Tan Jih Huei And Mathew Thomas. (2019). Predictors Of Mortality And Validation Of Burn Mortality Prognostic Scores In A Malaysian Burns Intensive Care Unit. – Bmc Emergency Medicine. 1-7.
- Shiplu Roy Chowdhury, Lim Shaun Jing, Muhammad Noor Haziq Bin Zolkafli, Nur Aqilah Binti Mohd Abu Zarin, Wan Alyani Binti Wan Abdullah, Nurul Aidah Binti Md Mothar, Manira Maarof & Nur Atiqah Haizum Abdullah. (2019). Exploring The Potential Of Dermal Fibroblast Conditioned Medium On Skin Wound Healing And Anti-Ageing. – Sains Malaysiana. 637-644.
- Ng Wan-Chiew, Marina Mat Baki, Mh Busra Fauzi, Yogeswaran Lokanathan And Mawaddah Azman. (2021). In Vitro Evaluation Of Biomaterials For Vocal Fold Injection: A Systematic Review. – Polymers. 1-22.