JSM Colloquium Series: From bench-to-bedside: Using gene expression as a means to fight cancers

Dear Prof./Dato/ Datin/ Assoc. Prof./ Dr./ Mr./ Mrs./ Ms.,

We are pleased to inform the JSM Colloquium Series will be held as follows:

Title               : From bench-to-bedside: Using gene expression as a means to fight cancers

Speaker         : Dr. Bernard Lee Kok Bang

                          Statistics Programme, Department of Mathematical Sciences,

                          Faculty of Science and Technology, Universiti Kebangsaan Malaysia.


Abstract        : Precision medicine has demonstrated that genetic features of cancer cells, i.e., gene expression, can be used for predicting drug response. Emerging evidence suggests that genedrug connections could be predicted more accurately by simultaneously exploring the cumulative effects of many genes. We developed DeSigN, a web-based tool for predicting drug efficacy against cancer cell lines using gene expression patterns. The algorithm correlates phenotype-specific gene signatures derived from differentially expressed genes with predefined gene expression profiles associated with drug response data (IC50). We and others subsequently demonstrated that DeSigN could robustly predict drugs that could benefit tumour control. For instance, less than 20% of head and neck cancer (HNC) patients, including oral cancer, would respond to three FDA-approved targeted therapies, underscoring the urgent need to develop more effective therapies. Using gene expression signatures derived from oral cancer, DeSigN predicted that bosutinib, an Src/Abl kinase inhibitor, as a sensitive inhibitor for oral squamous cell carcinoma (OSCC) cell lines. As a further confirmation, we demonstrated experimentally that bosutinib has anti-proliferative activity in OSCC cell lines. Here, we showed that DeSigN could be a means to identify efficacious drugs to fight cancers.


Date                     : 31 March 2023 (Friday)

Time                     : 10.00 am – 11.00 am

Medium              : i) Face-to-face (Venue: Bilik Kolokium Bangunan Sains Matematik, FST, UKM)

  1.  ii) Online (Facebook Jabatan Sains Matematik, FST, UKM)


JSM Colloquium Series is a program held to give a space for researchers and students to share knowledge and research related to mathematical sciences. We cordially invite you and your colleagues to participate in this colloquium or to distribute this information to other members/co-workers in your department or institution. Attendance will be recorded in URUSBAKAT for UKM Staff.

Further information related to the details and schedule in colloquium can be found on the following webpage: www.ukm.my/jsmt/kolokium.

Thank you.