Workshop Agenda:

• Session 1: Introduction to LCMS in Metabolomics

  • Overview of LCMS technology and its role in metabolomics research

  • Data acquisition methods and instrumentation for LC-MS analysis

  • Case studies highlighting the applications of LC-MS in metabolite identification and quantification

• Session 2: LC-MS based data processing

  • Understanding the concept of data processing for LC-MS based metabolomics

  • Data processing using MS-DIAL

  • Annotation using GNPS

  • Visualization using Cytoscape

• Session 3: LC-MS based data analysis

  • Practical data analysis using MetaboAnalyst

  • Application of multivariate analysis in Metabolomics

• As a pioneer in Metabolomics field in Malaysia, Professor Dr. Syarul Nataqain Baharum research is focused on the new insight of analytical and biological perspectives of the metabolomics in the field of systems biology, in particularly on the understanding of secondary metabolite production in local herbal plants as well as fluxomics studies. She has expanding her research focus in understanding host-pathogen interaction in aquaculture disease and also green therapeutic mechanism in neurogenerative diseases. In metabolomics research, pipeline of analytical tools such as LCMS, GCMS, CEMS, FTIR and NMR combined with Principal Component Analysis (PCA) is essential for the dynamic high throughput analysis. This frontier analysis which includes mathematical modelling has provided glimpse of cellular biology and fingerprint of functional network in the model organism in her lab. Currently she has published about 100 research articles, 4 books and 6 chapters in books. As project leader, she also received more than RM 4 million research grants in total amount. Under her supervision, 9 PhD students and 17 MSc were graduated. At the moment, she is supervising a total of 21 PhD students and 18 MSc students. She also has filed two patents and granted one Trade Mark (TM) and one Trade Secret.  Her work has been awarded prestigious awards including BioInnovation Awards in 2011 and Selangor My Innovation Award, 2014. She also engaged in collaborative partnership with industries such as Medika Natura Sdn Bhd, AAR Sdn Bhd and FGV Sdn Bhd.

• If you are interested to collaborate with her, or be part of her research group, please drop her an email to nataqain@ukm.edu.my.

• ChM. Dr. Kamalrul Azlan Azizan is a research fellow at INBIOSIS, UKM. He completed his PhD in Systems Biology in 2014 at the Universiti Kebangsaan Malaysia (UKM) in 2014. His research interest includes plant and microbial metabolomics as well as the application of chemometrics and multivariate for biomarkers discovery. Currently, he is working on bioprospecting allelochemicals from Wedelia trilobata using chemometrics and predictive models. 

• ChM. Dr. Kamalrul Azlan Azizan has a strong hands-on experience with GC-MS and LC-MS systems and actively involves in the development and optimization of GC/LC methods, giving guidance through application and troubleshooting assistance. He can be contacted via email; kamalrulazlan@ukm.edu.my 

• ChM. Dr. Nurkhalida Kamal completed her PhD in Pharmaceutical Sciences (Natural Products Chemistry & Metabolomics) from the University of Strathclyde, Glasgow, UK in 2015. She then worked as a Postdoctoral Fellow at the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS) focusing on metabolomics analysis of marine organisms including seaweed and marine microbes. She joined INBIOSIS in 2020 as a Research Fellow.

• Her research focuses on the application of metabolomics in natural products and food chemistry. She wants to understand the chemistry of various resources, why it is produced and what we can use it for. She has vast experiences in natural products isolation and elucidation from various organisms (plants, microbes, marine organisms and mushrooms), NMR and LCMS and chemometric data analysis. Her on-going research is to unravel the mechanism of immunomodulation of polyphenols-rich tempeh fraction on Caco-2 and HT-29 cell lines. Her interest also includes on using metabolomics as a tool to identify and biotechnologically optimize the production of bioactive secondary metabolites in medicinal plants, mushrooms, and microorganisms.

• Please feel free to visit her research group website (www.nurkhalidakamal.com) or contact ChM. Dr. Nurkhalida Kamal (nurkhalida.kamal@ukm.edu.my) for research and industrial projects collaboration. 

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